Ho apareloa ke lijo tse monate tsa lijo tsa lijo ho fetola mokhoa oa liphatsa tsa lefutso sebakeng sa boko bo amehang moputsong, 'me ho tlosoa ho lijo tsena ho fetola maikutlo a liphatsa tsa lefutso sebakeng sa boko bo amanang le khatello ea kelello (2014)

Joaloka batho, litoeba li pepesitsoe lijong tse nang le matla a matla-ho ja le ho ba boima bo feteletseng. Ho tlosoa ha lijo tsena ho etsa hore ho be le mekhoa ea ho imeloa kelellong, e ka hlalosang hore na ke hobane'ng ha batho ba thatafalloa ke ho ja.

Re ile ra pepesa likhoto ho lijo tse nang le matla a maholo e le hore re khetholle liphetoho tse teng bokong tse bakoang ke lijo tseo le ka ho tlosoa ha eona. Litlhapi tsa Dawley li ne li feptjoa ka li-lab-chow kapa lijo tse matlafatsang lijo (hammoho le chow). Ho latela libeke tsa 6 kapa li-15, halofo ea sehlopha ka seng e fetiselitsoe lijong tse hanyetsang. Li-rats li ne li hlahella 48-h hamorao. Re ile ra lekanya boholo ba mafura, li-hormone tsa plasma, 'me ra hlahlojoa kelello bakeng sa mokhoa oa mRNA oa liphatsa tse' maloa tsa liphatsa tsa lefutso. Liphoofolo tse feptjoang ke lijo tse jang lijo tsa motlakase li ne li ja li-kilojoule tse ngata, li lekanngoa ho feta 'me li phahamisitse leptin (hammoho le CORT e fokotsitsoeng libeke tse 15) ho ea ho likhoto tse fepehileng.

Libeke tse leshome le metso e mehlano tsa lijo tsa ho ja lijo li qeta khatello ea μ-opioid le CB1 receptor mRNA VTA, empa li-AMYGdala tse phahameng tsa GR, le libeke tsa 6 tsa lijo tsa lijo li fokotsa BDNF, ha li bapisoa le likhoto tse fepehileng. Li-rats tse fetisetsang lijo tsa lijo li ja lijo tse tšoanang le likhoho tse bolokiloeng ha li ja, 'me ho fetola lijo tsa ho ja lijo ka mor'a libeke tsa 15 li fokotsoe ke amygdala GR expression.

Li-rats li ile tsa fetola ho ja lijo tse seng kae ho feta likokoanyana tse bolokiloeng ka chow, 'me ho fetola libeke tse latelang tsa 15 tsa lijo tsa ho ja lijo ho ile ha eketsa hypothalamic CRH mRNA.

Ka lebaka leo, libeke tsa 15 tsa lijo tsa ho jela li hlahisitse liphetoho libakeng tsa boko bo amehang mekhatlong ea moputso. Ho fetola likokoanyana tsena ho etsa li-axis tsa HPA, ha ho fetola likokoanyana tse fepehileng ho lijo tsa lijo ho fokotsa ho bua ka GR ho amygdala, sebaka se amanang le khatello ea kelello. Liphuputso tsena li na le maikutlo a ho ja lijo ho batho.