Eur J Neurosci. 2017 Jan 23. doi: 10.1111 / ejn.13528.
Ouyang J1, Carcea I2,3,4, Schiavo JK2,3,4, Jones KT1, Rabinowitsch A1, Kolari R1, de Vaca SC1, Froemke RC, Carr KD1,5.
inahaneloang
Thibelo ea lijo tse sa foleng e ka ba le likarabo tsa boitšoaro le lisele tsa lithethefatsi tsa tlhekefetso le D-1 dopamine receptor agonists e tsamaisoang ka tsela ea ts'ebetso kapa ea sebakeng sa nucleus accumbens (NAc). Leha ho le joalo, liphetoho tsa NAc synaptic phetoho e tsamaisang liphello tsena li utloisisoa ka ho feletseng. Ho rekisa thepa ea AMPA ke mokhoa o ka sehloohong oa ho laola matla a synaptic, le lipatlisiso tsa pele li bontšitse hore ka bobeli sucrose le d-amphetamine li fetola ka potlako bongata ba likaroloana tsa tumello ea AMPA ho NAc postsynaptic density (PSD) ka tsela e fapaneng pakeng tsa dijo tse thibelang lijo le likhoto tse fepehileng tsa ad libitum. Phuputso ea hona joale e hlahlobile hore na thibelo ea lijo, ha ho se na phephetso ea khatello ea moputso, e fetola karolo ea AMPAR e ngata ho NAC PSD. Ho fumanoe thibelo ea lijo ho eketsa polelo ea holim'a metsi, haholo-holo PSD e ngata, ea GluA1 empa e se GluA2, e fana ka maikutlo a kenyelletso ea synaptic ea GluA2-e haelloang ke li-AMPAR (CP-AMPAR) tsa GluA2. Naspm, mohanyetsi oa CP-AMPAR, o ile a fokotsa boholo ba li-EPSC tse hlahisitsoeng ke Nac shell, 'me a thibela karabo e ntlafetseng ea ho fumana mohloli ho microinjection ea D-1 receptor agonist, SKF-82958, lijo tse thibetsoeng, empa e sa fepeloa ka libitum , lihlooho. Le hoja microinjection ea D-2 receptor agonist, quinpirole, le eona e ile ea etsa hore ho sebelisoe lijo tse ngata ho feta lijo tse fuoang libitum, phello ena e ne e sa fokotseha ke Naspm. Ho fumanoa hammoho, liphuputso tsa hona joale li lumellana le synaptic e kenyelletsang CP-AMPAR ho D-1 receptor e hlalosang li-neurone tse bohareng ba li-NAC e le tšehetso ea mekhoa ea ho amoheloa ha likhoto tse thibeloang lijo ho meputso ea tlhaho le lithethefatsi tsa tlhekefetso.
LINKOTSO: Ho lemalla; Ho ja lijo; Matšoao-bohloko; Moputso
PMID: 28112453
DOI: 10.1111 / ejn.13528
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