Tšebelisano ea lijo tse sa amoheleheng ea li-ghrelin le li-opioid receptor tsela ea mesolimbic dopamine system (2012)

Neuropharmacology. 2012 Dec 7; 67C: 395-402. doi: 10.1016 / j.neuropharm.2012.11.022.

Kawahara Y, Kaneko F, Yamada M, Kishikawa Y, Kawahara H, Nishi A.

mohloli o moholo

Lefapha la Pharmacology, Kurume University School of Medicine, 67 Asahi-machi, Kurume, Fukuoka 830-0011, Japane. Aterese ea elektronike: [imeile e sirelelitsoe].

inahaneloang

Ghrelin ke peptide e nkiloeng ka mpeng e entsoeng ka mpeng. Sepheo sa thuto e ne e le ho batlisisa boikarabelo ba li-receptor tsa ka hare le tsa kappa mokhoeng oa tsamaiso ea mekhoa ea methapo ea majoe dopamine tsamaiso.

Ho hlahloba ho sebelisana ha systemic ghrelin le litekanyetso tsa lijo moputso, likhoto li ile tsa pepesoa lijo ho tlosoa, kamehla lijo kapa e khahlisang lijo ka mor'a systemic ghrelin tsamaiso. Extracellular dopamine litekanyo li ne li lekantsoe ka nucleus accumbens (NAc) le metsoako e itseng ea receptor e kenngoa sebakeng sa ventral tegmental (VTA) se sebelisa microdialysis tse peli.

Tlhahiso ea kamehla kapa e khahlehang lijo ntle le tsamaiso ea ghrelin ea tsamaiso e entse hore ho eketsehe dopamine maemo ho NAc ka ts'ebetso ea li-mu opioid receptors ho VTA. Tsamaiso ea sistimi ea ghrelin (3 nmol, iv) e lateloa ke che lijo e baketse ho fokotseha ha dopamine litekanyetso ka ho kenyelletsa li-receptors tsa kappa li-opioid VTA. Tsamaiso ea tsamaiso ea ghrelin e lateloa ke ho sebelisoa ha kamehla lijo e bakisitse keketseho ho dopamine litekanyetso ka mokhoa o khethollang oa li-receptors tsa opioid, ha tsamaiso ea ghrelin ea tsamaiso e lateloa ke tšebeliso e ntle lijo a sitisa ho eketseha dopamine litekanyetso ka mokhoa o khethehileng oa ts'ebetso ea kappa ea opioid receptors.

Kahoo, tlhaho lijo moputso le systemic ghrelin li kopa ka le ka kappa opioid receptor tsela VTA, ka ho latellana, e leng ho fella ka litšusumetso tse fapaneng ka dopamine lokolloa NAC.

Ho feta moo, systemic ghrelin e etsa hore ho fetole tsela e kholo ea opioid receptor tsela e khotsofatsang haholo lijo ho tloha ho ea kappa ho kappa, ho fella ka ho tloswa ha mesolimbic dopamine tsamaiso. Liphuputso tsena tsa morao-rao li ka fana ka litsebo litseleng tsa neural tse amehang ho ho ja mathata.