Botenya (Silver Spring). 2012 Aug;20(8):1738-40. doi: 10.1038/oby.2012.17.
van de Giessen E1, La Fleur SE, de Bruin K, van den Brink W, Booij J.
inahaneloang
Mefuta e sa tšoaneng ea lijo tse phahameng tsa mafura (HF) e sebelisoa ho ithuta ho nona ho tlōla ho bakoang ke lijo (DIO) ka litoeba mme sena se lebisitse ho phenotypes e fapaneng. Phuputso ena e hlahloba hore na lijo tse fapaneng tsa HF li fapana ka tsela e fapaneng le ea malapa a fokolang (2 / 3) receptor (DRD (2 / 3)), ho fumaneha ha DRD (2 / 3) ho fokotseha ho amehile ka ho nona haholo ho amanang le ho haella ha lijo . Lipotlolo tse mashome a mararo li ne li khetholloa ka tsela e lekaneng bakeng sa phepo ea HF e sa lefelloeng (HF-khetho), lijo tsa premium HF (HF-no-choice), kapa lijo tsa standard chow bakeng sa matsatsi a 28. DRD e hlaselang (2 / 3) e ne e lekanngoa ho sebelisa imagiso ea phosphor (123) I-IBZM letsatsing la 29. DRD (2 / 3) e fumanehang haholo e ile ea fokotseha haholo ha ho e-na le litoeba tse khethiloeng ke HF ha li bapisoa le likhoho, empa ha li nkoe ke linkho tsa HF. Ho phaella moo, ho kenngoa ha lik'halori tsa likhoto tse khethiloeng ke HF ho ne ho phahametse haholo ho feta likhoho tsa HF-no-khetho le serum leptin le karolo ea lekholo ea mafura a mpa ea boima ba 'mele o ne o phahame ka ho fetisisa linthong tse khethollang HF ho bapisoa le likhoho tsa chow. Liphello tsena tsa pele li fana ka maikutlo a hore karolo e khethollang lijong tsa HF, tse ka 'nang tsa amana le litšusumetso tsa ho ja, li lebisa tlhokomelong e feteletseng le boemo bo fapaneng ba botenya. Liphello tsena li bohlokoa bakeng sa lithuto tsa nakong e tlang tsa DIO ha li nahana ka khetho ea mofuta oa lijo.
;