Metsoako. 2015 Mots'eanong 22; 7 (5): 3869-90. doi: 10.3390 / nu7053869.
Lekhetho A.1, Marshall P2, Zhou Y3, Kreek MJ4, Kent K5, BATHO BA SEBELETSI BA MOLIMO: Daniels S6, Lebōpo A7, LITTLE T8, Fernandes MF9, Ntlafatsa DM10, Leri F.11.
inahaneloang
Boithuto bona bo ithutile hore na litekanyetso tse fapaneng tsa fructose (F) le tsoekere (G) tsoekere li ka baka phapang e kholo lithutong tsa boits'oaro le likarabo tse amanang le 'mele le tsa mmele' meleng oa banna ba Sprague-Dawley. Boitekong ba 1, liphoofolo tse ipehang li-pellets tse nang le 55% F + 45% G kapa 30% F + 70% G, le immunoreactivity ea Fos li ile tsa hlahlojoa libakeng tsa hypothalamic tse laolang phepelo ea lijo le moputso. Boitekong ba bobeli, litharollo tse iphelisang tse tsamaeang le likhoto tse 2% F + 55% G (sirapo e phahameng ea li-fructose poone (HFCS), 42% F + 50% G (sucrose) kapa saccharin, le mRNA ea dopamine 50 (D2R) le mu-opioid (MOR) mefuta ea li-receptor e ile ea hlahlojoa libakeng tse amanang le litloaelo tsa boits'oaro. Qetellong, ho Teko ea 2, likhoto tse ikentseng HFCS le li-sucrose malapeng a tsona, le li-acid tse matla tsa hepatic li ile tsa hlakoloa. Ho fumanoe hore tekanyo e phahameng ea li-fructose e nolofalletsa boits'oaro bo tlase, polelo ea Fos e tlase ho "lateral hypothalamus / arcuate", e fokotsitse D3R mme ea eketseha MORNARR ka har'a dorsal striatum le nucleus accumbens core, ka ho latellana, hammoho le mafura a phahameng a omega-2 polyunsaturated asiti ka har'a sebete. Tdata ea hese e bonts'a hore tekanyo e phahameng ea fructose e ka ntlafatsa litlamorao tsa tsoekere mme mohlomong ea lebisa ho liphetoho tsa neurobiological le tsa mmele tse amanang le mathata a ho lemalla le a metabolic.
LINKOTSO:
dopamine 2 receptor; acid e mafura; fructose; tsoekere; hepatic; hypothalamus; mu opioid receptor; li-nucleus accumbens; rat; itaola
PMID: 26007337
PMCID: PMC4446784
DOI: 10.3390 / nu7053869
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