Kutloisiso ea Hedonic bakeng sa meputso ea tlhaho e ameha ke khatello ea bokhachane ka mokhoa o itšetlehileng ka thobalano (2015)

Ho lemalla Moferefere. 2015 May 26. Doi: 10.1111 / adb.12270.

Reynaert ML1,2, Marrocco J3, Mairesse J1,2, Lionetto L4, Simmaco M4, Deruyter L1,2, Allorge D5, Moles A6,7, Pittaluga A8, Maccari S1,2, Morley-Fletcher S1,2, Van Camp G1,2, Nicoletti F1,2.

inahaneloang

Lijo tse nang le phepo e ntle ke ts'usumetso e matla ea "circry" ea moputso mme li ka baka boitšoaro bo bobe bo lebisang khatellong ea lijo. Hore na liketsahalo tsa bophelo ba pele le thobalano li kenella joang ho fetoheng maikutlo a hedonic lijong tse fumanehang habonolo ha ho tsejoe. Re sebelisitse likhoto tse thibelang bokhachane (prenatally restret) tse hatisitsoeng (PRS), tse bonts'ang tlhekefetso ts'ebetsong ea moputso le boits'oaro / ho tepella maikutlong joalo ka boitšoaro. Tse ling tsa matšoao a likhoto tsa PRS li tsejoa hore li a ts'epa. Re tlaleha hore PRS e ntlafalitse le ho fokotsa lebese la chokolete e kenyellelitsoeng pele ho banna le basali, ka ho latellana. Malebela a PRS a banna a boetse a bontša ho eketseha ha maemo a plasma dihydrotestosterone (DHT) le dopamine (DA) maemong a nyutlelie (NAc), le phokotso maemong a 5-hydroxytryptamine (5-HT) ho NAc le preortal cortex (PFC). Ho litoeba tsa banna, kalafo e hlophisehileng le DHT-e fokotsa lithethefatsi tse fokotsang lithethefatsi e fokotsa likhetho tsa chisi ka bobeli le maemo a NAc DA.

Rats ea PRS ea basali e bontšitse li-estradiol tsa plasma tse tlase (E2 ) maemo le litekanyetso tse tlase tsa DA ho NAc, le maemo a 5-HT ho NAc le PFC. E2 tlatsetso e khutlisitse phokotseho ea khetho ea chisi ea chisi le maemo a PFC 5-HT. Ho hypothalamus, PRS e ile ea eketsa ERcy le ERβ estrogen receptor le CARTP (cocaine-and-amphetamine receptor transcript peptide) maemo a mRNA ho banna, le 5-HT2 C maemo a receptor mRNA ho basali. Liphetoho li ile tsa lokisoa ke kalafo e nang le Finasteride le E2 , ka ho latellana.

Liphumano tsena tse ncha li bonts'a hore khatello ea bophelo ba pele e na le ts'ebetso e kholo ho maikutlo a hedonic ho lijo tse matlafatsoang ka liphetoho tse tšoarellang li-hormone tsa gonadal. Sena se bula tsela ea nts'etsopele ea maano a lihormone a reretsoeng ho lokisa lits'oants'o karabong ea meputso ea tlhaho.