PLoS One. 2019 Jan 4; 14 (1): e0210184. doi: 10.1371 / journal.pone.0210184.
Fukuhara S1, Nakajima H1,2, Sugimoto S1, Kodo K2, Shigehara K1, Morimoto H1, Tsuma Y1, Moroto M1, Mori J1, Kosaka K1, Morimoto M1, Hosoi H1.
inahaneloang
Rett syndrome (RTT) ke lefu le amanang le X le amanang le neurodevelopmental le bakoang ke phetoho ea liphatsa tsa lefutso tsa methyl-CpG-binding protein 2 (MECP2). Le ha RTT e amahanngoa le botenya, mochini o ka tlase ha o so hlakisoe. Phuputsong ena, litoeba tse tšehali tsa heterozygous Mecp2-null (Mecp2 +/- litoeba), mohlala oa RTT, li ile tsa fepuoa lijo tse tloaelehileng tsa chow kapa phepo e mafura a mangata (HFD), 'me ha batloa lipatlisiso tsa litsela tsa ho bontša limolek'hule. Haholo-holo, re hlahlobile polelo ea liphatsa tsa lefutso tse amanang le potoloho ea moputso oa hypothalamus le dopamine, e emelang khokahano e bohareng ea taolo ea boitšoaro. Haholo-holo, potoloho ea moputso oa dopamine e bonts'itsoe ho laola boitšoaro ba phepo ea hedonic, mme pherekano ea eona e amahanngoa le liphetoho tse amanang le HFD mabapi le ho khonahala. Mecp2 +/- litoeba tse fepuoang chow e tloaelehileng li bontšitse boima bo tloaelehileng ba 'mele le ts'ebeliso ea lijo, athe tse fepang HFD li bontšitse botenya bo fetelletseng ka hyperphagia, keketseho ea mafura a' mele, ho hloka mamello ea tsoekere le ho hanela insulin ha e bapisoa le litoeba tsa mofuta o hlaha litoeba tsa HFD (WT-HFD). Lebaka le ka sehloohong la botenya ho Mecp2 +/- litoeba tsa HFD e bile keketseho e makatsang ea khalori e kenang, ho se phapang ea ts'ebeliso ea oksijene kapa ts'ebetso ea locomotor. Mefuta ea peptide mRNA e amanang le Agouti le liprotheine li eketsehile, athe proopiomelanocortin mRNA le liprotheine li fokotsoe ho Mecp2 +/- litoeba tsa HFD tse nang le hyperleptinemia, tse phethang karolo ea bohlokoa ho takatso ea lijo le ho khotsofala ho hypothalamus. Teko ea khetho ea sebaka se hlophisitsoeng e senotse hore Mecp2 +/- litoeba li khethile HFD. Tekanyo ea Tyrosine hydroxylase le dopamine transporter mRNA sebakeng sa ventral tegmental, le dopamine receptor le dopamine- le cAMP-e laoloang phosphoprotein mRNA maemo a li-nucleus accumbens a ne a le tlase haholo ho Mecp2 +/- litoeba tsa HFD ho feta tsa litoeba tsa WT-HFD. Kahoo, phepelo ea HFD e bakile phokotso ea phepelo ea lijo ho hypothalamus le dopamine moputso oa potoloho, mme ea potlakisa nts'etsopele ea botenya bo feteletseng bo amanang le boits'oaro-joalo ka boitšoaro ba ho ja ho Mecp2 +/- litoeba.
PMID: 30608967
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