F. Naneix, F. Tantot, C. Glangetas, J. Kaufling, Y. Janthakhin, C. Boitard, V. De Smedt-Peyrusse, JR Pape, S. Vancassel, P. Trifilieff, F. Georges, E. Coutureau le G. Ferreira
eNeuro 29 Mots'eanong 2017, ENEURO.0120-17.2017;
ETSAHALA: https://doi.org/10.1523/ENEURO.0120-17.2017
inahaneloang
Bopaki bo ntseng bo eketseha bo fana ka maikutlo a hore tšebeliso ea lijo tse nang le mafura a mangata (HFD) e ka ama phetoho ea lipotoloho tsa boko - joalo ka lilemong tsa bocha - e ka etsang hore ho be le liphetoho tse amanang le boits'oaro. Thutong ea hona joale, re sebelisitse sensitization ea boitšoaro ho amphetamine ho fuputsa phello ea periadolescent HFD exposition (pHFD) ka likhoto mabapi le ts'ebetso ea sistimi ea dopamine (DA), sebapali sa sehlohlolong sa ts'ebetso ea moputso oa lijo. pHFD ha e ame ho araba ente e mpe, leha ho le joalo, ho pepesetsoa amphetamine e le 'ngoe ho lekane ho susumetsa sensitization ea locomotor ho litoeba tsa pHFD. Sena se bapisoa le liphetoho tse potlakileng tsa neurobiological tsamaisong ea DA. Ho liphoofolo tse pepesitsoeng ke pHFD, ho pepesetsoa amphetamine e le 'ngoe ho etsa hore ho be le keketseho ea ts'ebetso ea ho phatloha ha lisele tsa DA sebakeng sa moea o kenang ka mokokotlong hammoho le tokollo e phahameng ea DA le polelo e kholo ea (tyrosine hydroxylase) ka har'a nucleus accumbens (NAc). Post-synaptic, liphoofolo tsa pHFD li bonts'a keketseho ea li-receptors tsa NAc D2 le polelo ea c-Fos kamora ho kenngoa ka ente ea amphetamine. Liphumano tsena li bonts'a kotsi ea ts'ebetso ea DA ts'ebeliso ea HFD nakong ea bocha e ka ts'ehetsang khaello ea lits'ebetso tse amanang le moputso tse bonoang bothateng.
Polelo ea Bohlokoa Ts'ebeliso ea ja lijo tse nang le phepo e ntle e ka ama nts'etsopele ea tsamaiso ea moputso, ea lebisa ho liphetoho tsa kelello le boits'oaro bo amanang le botena. Phuputso ena e etsa lipatlisiso ka litlamorao tsa tšebeliso ea mafura a mangata (HFD), ho tloha bongoaneng ho fihlela motho e moholo, ts'ebetsong ea sisteme ea mesolimbic dopamine (DA) e sebelisang sensitization ho amphetamine. Re bontša hore ho pepesetsoa ke amphetamine e le 'ngoe ho lekane ho susumetsa boits'oaro bo botle ho liphoofolo tse pepesitsoeng ke HFD. Sena se kopantsoe le maikutlo a tseleng ea mesolimbic ea DA, ka ts'ebetso e phahameng ea ts'ebetso ea li-neuron tsa DA le tokollo e ntlafalitsoeng ea DA, polelo e kholo ea tyrosine hydroxylase, li-receptor tsa D2 le maemo a c-Fos ho NAc. Phuputso ena e bonts'a hore ho pepesehela ts'ebeliso ea lijo tsa obesogenic pele ho nako ho fetola kutloisiso ea tsamaiso ea DA e ka lebisang ho mathata a amanang le moputso.
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