Ho feto-fetoha ha maikutlo a tšusumetso e matla ka li-receptor tsa prefrontal cortical mu-opioid ho itšetlehile ka pontšo ea amohelo ea D1 receptor sebakeng sa moo (2018)

Neuropharmacology. 2018 Sep 15; 140: 302-309. doi: 10.1016 / j.neuropharm.2018.07.033.

Selleck RA1, Giacomini J2, Buchholtz BD3, Letša C3, Sadeghian K4, Baldo BA5.

inahaneloang

Ho ba le tšoaetso ea lefu la opioid ho entsoeng ke mafu a kelello a nang le khatello ea kelello ka lebaka la tšusumetso e matla ea maikutlo, e kang ho lemalla le ho tšoaroa ke ho itlopa joala. Re kile ra bontša hore ho tšoaetsoa ha "μ-opioid receptor (μOR) agonist DAMGO ho e-na le tšusumetso e matla ea phekolo ea motsoako (vmPFC) ho susumelitse hyperphagia, ho eketseha ha motlakase, le ho arabela ka matla a methapo-ts'ebetsong mosebetsing oa boipheliso (PR), o lekanyang bohlokoa ba ho susumetsa maikutlo. Liphello tsena ha lia ka tsa hlahisoa ke ho kenngoa ha intra-PFC ea mefuta-futa ea li-agonists le bahanyetsi, e leng ho fana ka maikutlo a hore ho senya tsamaiso ea DA ea intra-PFC feela ha hoa lekaneng ho hlahisa lik'hamphani tse tšoanang le tsa μOR. Leha ho le joalo, sena ha se fane ka likamano lipakeng tsa PFC DA le mefuta ea μ-opioid. Mona re sebelisitse li-cocktails tsa intra-vmPFC tse nang le DAMGO le SCH 23390 (mohanyetsi oa DA D1). Ho fumana hore na keketseho ea tšusumetso e matla le liketso tsa motlakase e entsoeng ke intra-vmPFC stimulating e hloka hore ho be le pontšo e tiileng ka vmPFC D1 receptors. Ho thibeloa ha li-receptor tsa D1 le SCH 23390 ho hlokometse ho ntlafatsoa ha PPR, le ho eketseha ha boitšoaro bo joalo ba ho hlahloba le ho qala ho fepa ho entsoeng ka intra-vmPFC μOR tsusumetso. Liphello tsena li etsa hore pontšo ea intra-vmPFC D1 e hlokahale bakeng sa polelo ea boitšoaro bo hlephileng bo susumelitsoeng ke OR mo susumetsang ka hare ho PFC, hape e fana ka maikutlo a hore molumo oa D1 o phetha karolo e lumellang kapa e lumellang ho hlahisa mekhoa ea μOR. Merero ea nako e le 'ngoe ea μ-opioid le D1 tsamaiso e ka' na ea emela leano le atlehileng haholoanyane la phekolo (ho bapisoa le μOR ho thibeloa feela) bakeng sa mathata a kelello a khetholloang ke tšusumetso e matlafalitsoeng.

LINKOTSO: Dopamine D1 receptor; Ho fepa; Lijo tse susumetsang; Mokamo oa opioid; Prefrontal cortex; Rat