Maikutlo: Liphuputso tsa liphoofolo tsa pejana li bonts'a tahlehelo ea li-receptor tsa D2 tse bakoang ke ho ja haholo, mme lithuto tsa batho li bonts'a keketseho ea li-receptor tsa dopamine D2 ha bakuli ba batenya haholo ba theola boima ba 'mele. Sena ha se rarolloe.
Henry K. Karlsson1, Lauri Tuominen1,2, Jetro J. Tuulari1, Jussi Hirvonen1,3, Riitta Parkkola3, Semi Helin1, Paulina Salminen4, Pirjo Nuutila1,5, le Lauri Nummenmaa1,6
Menehelo ea Mongoli: JH, PN, le LN ba entse lipatlisiso; HKK, LT, JJT, RP, SH, PS, le LN ba entse lipatlisiso; HKK, LT, JJT, RP, le LN e hlahlobisitsoe dintlha; HKK, LT, JJT, JH, PN, le LN ba ngotse pampiri ena.
- Journal of Neuroscience, 4 March 2015, 35(9): 3959-3965; doi: 10.1523/JNEUROSCI.4744-14.2015
inahaneloang
Mekhoa e metle ea ho kula le ho nona haholo ha e utloisisoe hantle. Le hoja lithuto tsa pele li bontšitse hore li eketsehile μ-opioid receptor (MOR) mme e theohile dopamine D2 amohela (D2R) ho fumaneha ha mathata a ho lemalla, karolo eo mekhatlo ena e e bapalang botenya ba motho e sa ntsane e hlakile. Re ithutile basali ba batenya haholo ba 13 [bolelang 'mele oa boima ba motsoako (BMI), 42 kg / m2] le basali ba 14 bao e seng khale ba tšoana le bona, le boko ba MOR le D2R ho fumaneha ho sebelisa PET le melaetsa ea li-radio (11C] carfentanil le [11C] raclopride, ka ho latellana. Re ne re boetse re sebelisa mekhoa e mengata ea ho etsa lipatlisiso tsa mekhoa ea ho etsa lipatlisiso tsa mekhoa e mengata ea ho fumana botenya ba pele ho liphello tsa botenya ho fetotsoeng D2R fumaneha.
Lihlooho tse nang le bobebe haholo li ne li e-na le bothata bo fokolang haholo ho feta ho laoloa libakeng tsa bokooa tse amanang le moputso, ho akarelletsa le ventral striatum, insula le thalamus.
Ho feta moo, libakeng tsena, BMI e tsamaisana le ho fumaneha ha MOR. Kakaretso ea MOR ea lefu la sethoathoa e ne e boetse e amahanngoa le mekhoa ea ho lemalla lijo le ho thibela mekhoa ea ho ja.
Ho ne ho se na phapang e khōlō D2R ho fumaneha pakeng tsa lihlooho tse mahlahahlaha le tse se nang tsebo sebakeng leha e le sefe sa boko. Tlhahlobo ea litlhahlobo e tiisitse hore bopaki ba hona joale bo fetotsoeng D2R ho fumaneha ka botenya ke boinyenyefatso feela. Botenya bo bonahala bo e-na le mekhoa e ikhethang ea phekolo ea methapo ea methapo ea potoloho ea potoloho ea potoloho, eo e leng e tšoanang haholo le ho lemala ho opioid ho feta mathata a mang a ho lemalla.
Lenaneo la opioid le etsa hore ho be le tšusumetso le moputso, le ho fumaneha ha tlaase μ-opioid ho ka khothalletsa ho ja ho ja ho fokotsa likarabo tsa hedonic tse fokotsehileng tsamaisong ena. Mekhoa ea boits'oaro le ea meriana bakeng sa ho fumana phekolo ea opioidergic e ka 'na ea e-ba ea bohlokoa ho thibela seoa sa botenya haholo.
SEHLOOHO
Botenya bo amanang le methapo ea kutlo ea boko
Ka March 4th, 2015 ka Neuroscience /
Botenya bo amahanngoa le ho fumaneha ha thepa ea opioid receptor (mela e ka hodimo) athe ho fumaneha ha li-receptor tsa dopamine ha ho fetohe. Bokooa ka lehlakoreng le letšehali ke ba batho ba feteletseng le boko bo ka ho le letona ho batho ba tloaelehileng ba boima. Mokoloto: Univesithing ea Aalto
Bafuputsi Univesithing ea Aalto le Univesithi ea Turku ba senoletse kamoo botenya bo amanang kateng le ho fetoha ha pelo ea opioid neurotransmission bokong.
Phuputso e ncha e senola kamoo botenya e amahanngoa le ts'ebetso e fetotsoeng ea sistimi ea opioid ea boko, e amehang haholo ho hlahiseng maikutlo a monate. Bafuputsi ba fumane hore botenya bo amana le palo e theohileng haholo ea li-opioid receptors bokong. Leha ho le joalo, ha ho liphetoho tse bonoeng tsamaisong ea dopamine neurotransmitter, e laolang likarolo tse susumetsang tsa ho ja.
Botenya ke phephetso e kholo ho bophelo bo botle ba batho lefats'eng ka bophara kaha bo amahanngoa le maemo a tebileng a bongaka a mofuta oa mofuta oa 2 lefu la tsoekere, lefu la pelo ea coronary, le stroke. Le hoja ho tsejoa hantle hore mekhoa e sa nepahalang ea ho ja ke eona ntho e ka sehloohong e bakang botenya, hangata batho ba na le bothata ba ho thibela lijo tsa bona.
Liphuputso tsa rona li totobatsa kamoo botenya bo amanang le liphetoho tsa limolek'hule tsa boko. Ho ka etsahala hore ho haella ha boko li-receptors tsa opioid e etsa hore batho ba mahlomoleng ba tsebe ho ja lijo tse fokolang, ho bolella moprofesa Lauri Nummenmaa le mofuputsi Henry Karlsson.
Liphuputso li na le moelelo o moholo oa kutloisiso ea rona ea lisosa tsa botenya. Li re thusa ho utloisisa mekhoa e amanang le ho ja lijo tse ngata, le ho fana ka temohisiso e ncha kalafo ea boitšoaro le ea meriana le thibelo ea botenya. Leha ho le joalo, ha re e-s'o tsebe hore na ho fetoha ha kelello ea methapo ea kelello ke sesosa kapa phello ea botenya.
Bafuputsi ba lekanya ho fumaneha ha li-opioid le mofuta oa 2 dopamine receptors ka boima ba 'mele batho ba bangata haholo'boko bo sebelisang positron emission tomography Setsing sa PET Turtu.
Liphuputso li ile tsa hatisoa ka March 3, 2015 koranteng ea saense ea The Journal of Neuroscience.
E fanoe ke Univesithi ea Aalto
“Botenya bo amanang le methapo ea kutlo ea boko.” La 4 Hlakubele, 2015. http://medicalxpress.com/news/2015-03-obesity-brain-neurotransmitters.html
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