Brain Res Mol Brain Res. 2004 May 19;124(2):134-42.
Spangler R1, Koloi ea Wittkowski, Mohlomphehi NL, Avena NM, Hoebel BG, Leibowitz SF.
inahaneloang
Lithethefatsi tse hlekefetsoang ke batho ho nahanoa hore li etsa hore likarolo li sebetse kahare ho bokong ba boko bo kenyang setho nthong e kholo ea boits'oaro, joalo ka ho ja.
In ts'ehetso ea sena, re tlaleha mona hore libaka tse emeng tsa likhoto tse tsoekere ka tsoekere li bonts'a liphetoho maemong a dopamine le a opioid mRNA a tšoanang le likhoto tse itšetlehileng ka morphine. Haholo-holo ka mor'a kemiso e sa foleng ea ho itlopa joala nako le nako ka tharollo ea sucrose, litekanyetso tsa mRNA bakeng sa D2 dopamine receptor, le liphatsa tsa lefutso tsa preroenkephalin le li-prerotachykinin li ile tsa fokotseha libakeng tsa dopamine-receptor ea forebrain, ha D3 dopamine receptor mRNA e ntse e eketseha.
Le ha morphine e ama polelo ea liphatsa tsa lefutso ho pholletsa le boemo bohle bo amohelang dopamine, phapang e kholo e fumanoe litlamorao tsa tsoekere ho li-nucleus accumbens le haufi le caudate-putamen. Litlamorao tsa tsoekere maemong a mRNA e ne e le kholo haholo bokong ba li-nucleus ho feta ho caudate-putamen. Libaka tsena li boetse li bonts'itse phapang e hlakileng litšebelisanong har'a liphatsa tsa lefutso, haholo lipakeng tsa D3R le liphatsa tse ling tsa lefutso. Sena se senotsoe ke mokhoa oa tlhahlobo oa tšebeliso ea li-multivariate tse boneng tšebelisano 'moho lipakeng tsa liphatsa tsa lefutso, haholo-holo ka har'a li-nucleus accumbens empa eseng caudate-putamen. Qetellong, karolo ea litšebelisano tsena tsa tšebelisano-'mabo karabong e arolelanang boima le litšila tse bakoang ke tsoekere e tšehelitsoe ke ho fumana mofuta o fapaneng oa khokahano lipakeng tsa liphatsa tsa lefutso libakeng tse peli tse sisimosang.
Tliphumano tsa hese li ts'ehetsa karolo e kholo bakeng sa li-nucleus tse bokellanang ho hokahanya litlamorao tsa lintho tse fanang ka melemo ea tlhaho le ho atolosa mohlala oa phoofolo bakeng sa ho ithuta likarolo tse tloaelehileng tsa ts'ebeliso ea lithethefatsi le mathata a ho ja.
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