Likamano tse hanyetsanang tsa BMI le BOLD le dopamine D2 / 3 e amohelang bokhoni ba ho kopanya dorsal striatum (2015)

Synapse. 2015 Feb 9. Doi: 10.1002 / syn.21809. [Epub pele ho khatiso]

Cosgrove KP1, Veldhuizen MG, Sandiego CM, Morris ED, DM e nyane.

inahaneloang

Liphumano tse tsoang liphuputsong tsa bongaka le tsa preclinical li fetoha ho fana ka maikutlo a hore ho eketseha ha takatso le / kapa ho pepesehela lijo tse nang le mafura a mangata ho amana le liphetoho lipakeng tsa dorsal striatal (DS). Ho batho ho na le kamano e tšepahalang pakeng tsa index ea mmele (BMI) le karabelo ts'ebeliso e ntle ea lijo ka har'a dorsal striatum (DS). Lithuto tsa Positron emission tomography (PET) li boetse li fana ka tlhahiso ea phetoho ea DS dopamine mofuta 2 / 3 receptor (D2R / D3R) ho fumaneha ha botenya; leha ho le joalo, tataiso ea mokhatlo ha e hlake. Ha ho hlake hape hore na maemo a "dopamine receptor" a thusa hakae maemong a fokotsang oksijene ea mali (BOLD) hobane lithuto tsa PET li lebisitse ho litekanyetso tsa boitšoaro bo bobebe hape, le lipalo tsa "imaging resonance imaging (fMRI) tse sebetsang ka seoelo ha li kenyeletse batho ba nang le li-BMI mokhatlong ona. Ka hona re ile ra hlahloba hore na karabelo ea fMRI BOLD ho DS ho milkshake e amana le ho fumaneha ha D2R / D3R ho lekantsoe le [11 C] PhNO le PET ho batho ba nang le BMI ho tloha ka boima ba 'mele ho ea ho tse ling tse itekanetseng. Lithuto tse mashome a mabeli a metso e robong tse nkile karolo lithutong tsa fMRI, tse leshome le metso e 'meli ho [11 C] Boithuto ba PHNO PET, bao ba robeli ba bona ba qetileng thuto ea fMRI. Joalokaha ho boletsoe esale pele ho bile le kopano e mpe lipakeng tsa karabelo ea DS BOLD ho milkshake le BMI. Ka lehlakoreng le leng, BMI e ne e amana hantle le ho fumaneha ha D2R / D3R. Karabelo ea Dorsal striatal BOLD e ne e sa tsamaisane le ho fumaneha ha D2R / D3R. Ha ho nahanoa ka moelelo oa lingoliloeng tse kholo, sephetho sa rona se bontša hore ho na le kamano e seng molaong lipakeng tsa D2R / D3R fumaneha le BMI. Ntle le moo, likarabo tse fetotsoeng tsa BOLD ho litheko tse matlafatsang tsa lijo tse bonoang bothateng ha li amane ka botlalo le ho fumaneha ha li-receptor tsa D2R / D3R. Sengoliloeng sena se sirelelitsoe ke tokelo ea molao. Litokelo tsohle li sirelelitsoe.

© 2015 Wiley Pensionicals, Inc.

LINKOTSO:

BMI; BOLA; PET; [11C] - (+) - PHNO; dopamine D2 / 3 receptor; fMRI; motho