Neurobiol Dis. 2016 Feb 25. pii: S0969-9961(16)30042-0. doi: 10.1016/j.nbd.2016.02.021.
Likoti EG1, Taylor JR2, Gourley SL3.
inahaneloang
Botiki e entsoeng ka methapo ea kutlo (BDNF) e ama polasetiki ea synaptic le sebopeho sa neural mme e bapala likarolo tsa bohlokoa ho ho ithuta le ho hopola lintho. Bopaki ba morao-rao bo boetse bo supa likarolo tsa bohlokoa le tse rarahaneng tsa BDNF ka mefuta e makatsang ea tlhekefetso ea koae le bokhoba. Mona re lekola karolo ea pele ho khetho ea liqeto tse amanang le cortical (PFC) BDNF mabapi le ho etsa liqeto tse amanang le moputso le kutloelo-bohloko ea boitšoaro ho cocaine. Re tsepamisa maikutlo ho BDNF kahare ho PFC ea moriana kapa e tsoetseng pele, taolo ea eona ea koae ka nako ea khokahano ea pelehi le ho ba motho e moholo, le kamoo BDNF le eona e nang le tšusumetso ea ts'ebeliso ea litlhare, ho kenyeletsoa mehlala ea ho khutlisetsoa morao. Ha ho hlokahala, re etsa papiso le lipapiso le liteko tse sebelisang litlatsetso tsa tlhaho (lijo). Re boetse re akaretsa lintlha tse fumanoeng tse tšehetsang, kapa tse hanyetsang, monyetla oa hore BDNF ho tsa marang-rang le meketjana ea PFC e laole nts'etsopele le ho boloka mekhoa ea karabelo. Patlisiso e eketsehileng e ka thusa ho nts'etsopele ea mekhoa ea ho phekola lipale tse fumanehang bakeng sa mathata a tšebeliso ea koae.
LINKOTSO: Tlatsetso; Mohlodi; Sebetsa; Orbitof Pambal; Prelimbic; tataisoa sepheo; lekola
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