Mol Neurobiol. 2019 Jan 2. doi: 10.1007 / s12035-018-1453-6.
Saad L1,2, Sartori M1,3, Pol Bodetto S1, Romieu P1, Kalsbeek A2,4, Zwiller J1, Anglard P5,6.
inahaneloang
Likokoana-hloko tsa DNA methylation le orexin-type-1 li-antagonists li hanyetsa liphello tsa neurobiological ho khanna lithethefatsi tsa tlhekefetso le li-reinforcers ka ho etsa hore mekhoa e tloaelehileng ea boko bo sebetsane le mokhoa oa moputso oa mahlo. Phuputsong ena re sebelisitse puso ea boipheliso ho hlahloba ho ameha ha maemo a laolang DNA methylation ts'ebetso le lipontšo tsa satiety kapa takatso ea lijo. Lintlha tsena li kenyelletsa Dnts and Tets, miR-212 / 132, orexins, le liphatsa tsa orx-R1. Phuputso ena e ile ea lebisa tlhokomelo libakeng tse hlalosang dopamine tse kang prefrontal cortex (PFCx) le caudate putamen (CPu) le hypothalamus (HP) e kopanetsoeng le mokhoa oa moputso. Liphetoho tse matla li ile tsa hlokomeloa ha li arabela ka bobeli, empa li fapane ho itšetlehile ka tlhaloso e sa tsoaneng le e sa phekoleheng. Tlhaloso e ne e boetse e fapane le PFCx le CPu. Cocaine le lijo li bile le liphello tse fapaneng le tse ling ka Dnmt3a lipolelo tse peli tsa boko, ha li ntse li hatella li-miRs ka tsela e fapaneng, ntle le ho ama maikutlo a tsona a mantlha ka CPu. Ka tšohanyetso, li-mRNA tsa orexin li fumanoe CPu, li fana ka maikutlo a ho tsamaisa ho tloha setsing sa bona sa transcription ho HP. Lefu la orexin receptor1 le fumanoe le bakoa ke cocaine le PFCx, e lumellanang le molao oa DNA methylation. Likarolo tsa 5-methylcytosine tsa PFCx ha lia fetoha haholo ka k'hok'heine, li fana ka maikutlo a hore ke sebaka sa bona se ajoang se tlatsetsang boitšoarong bo tšoarellang. Hammoho, dintlha tsa rona li bonts'a hore DNA methylation e laolang maemo e fetoha ka tsela e fapaneng le cocaine le lijo. Libokeng tsa limolek'hule, li tšehetsa khopolo ea hore lipotoloho tsa neural tse nkiloeng ke li-reinforcers ha li kopane ka ho feletseng.
LINKOTSO: Ho lemalla; Cocaine le lijo tsa boipheliso; DNA methylation; Lithethefatsi tsa tlhekefetso; Epigenetics; Li-Orexin / hypocretins
PMID: 30603957
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