Khopolo-taba. 2015 Mar 19; 289: 19-42. Doi: 10.1016 / j.neuroscience.2014.12.046.
Liu S1, Borgland SL2.
inahaneloang
Li-polypeptides tse hlahisoang ka mpeng, mala, li-adipocyte, manyeme le boko tse susumetsang ho ja li bitsoa li-peptide tse amanang le 'fepa. Boholo ba li-peptide tse susumetsang ho fepa li na le tšusumetso e thibelang (li-peptide tsa anorexigenic). Ka lehlakoreng le leng, ke ba fokolang feela ba nang le tšusumetso e matlafatsang (orexigenic peptides), joalo ka ghrelin. Ho fepa ka lapeng ho bolela ha lijo tse jeoang li lekana le khaello ea matla. Leha ho le joalo, sechabeng sa bophirima moo phihlello ea lijo tse bonoang tse nang le matla a mangata li batlang li se na moeli, lijo li jeoa haholo ka mabaka a seng malapeng. Bopaki bo hlahang bo kenyelletsa litsamaiso tsa mesocorticolimbic, ho kenyeletsoa le li-dopamine neurons tsa sebaka sa ventral tegmental (VTA), e le karolo ea bohlokoa bakeng sa phepo e seng ea malapeng. VTA dopamine neurons encode cues e bolelang esale pele meputso le tokollo ea phasic ea dopamine ka har'a ventral striatum e susumetsang liphoofolo ho fepa lijo. Ho hlakisa hore na li-peptide tse amanang le ho fepa li laola tsela ea moputso ho bohlokoa joang ho senola mekhoa e fepelang e seng ea homeostatic kapa ea hedonic. Mona, re lekola tsebo ea hajoale ea kamoo li-peptide tsa anorexigenic le li-peptide tsa orexigenic li sebetsang ka har'a VTA
LINKOTSO:
anorectic; dopamine; li-peptide tse fepang; boits'oaro ba ho ingestive; orexigenic; tikoloho e khelohileng ea moea
PMID: 25583635
DOI: 10.1016 / j.neuroscience.2014.12.046
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