Am J Physiol Regul Compact Comp Comp Physiol. 2003 May;284(5):R1260-8.
Bello NT1, Sweigart KL, Lakoski JM, Norgren R, Hajnal A.
inahaneloang
Boithuto ba morao-rao bo bonts'a hore sistimi ea dopamine ea mesoaccumbens e kenella ka har'a liphetoho tsa neurochemical ka lebaka la maemo a thibeloang a ho fepa ka phihlello ea tsoekere. Matla ana a bonahala a tšoana le neuroadaptation e hlahisoang ke lithethefatsi tsa tlhekefetso mme e ka baka boitšoaro bo bong ba ho fepa.
Ho etsa lipatlisiso ho feta mekhoa ea lisele tsa liphetoho tsena, boithuto ba hona joale bo sebelisitse boholo ba litaba tsa boithuto ba bona le maemong a ntlafalitsoeng ho lekola dopamine membrane transporter (DAT) protheine ea lenane le polelo ea mRNA maemong a thibeloang a batho ba baholo le a mahala. Mokhoa o felletseng oa ho fepa o ne o kenyelletsa phihlello ea letsatsi le letsatsi ea ho fumana tharollo ea kamehla (0.3 M) kapa chow eo a e ratang ka mokhoa oa matsatsi a 7. Likhoto tse matlafalitsoeng tse nang le phepo e kenang ea phepelo ea mali li ile tsa theola boima ba 'mele, tsa ja lijo tse felletseng, tsa ba tsa noa metsi a mangata ho feta tse feptjoang mahala, lijo tse hanyetsanang kapa taolo e sa laoleheng. Ntle le moo, liphoofolo tsena li ne li e-na le letsatsi le phahameng la ho ikopanya le ho ikatisa ho bokellaneng ba nucleus. Keketseho ena ea ho tlama liprotheine le eona e ne e tsamaisana le keketseho ea litekanyetso tsa DAT mRNA sebakeng sa tefo ea ventral. Ha ho bapisoa le lihlopha tse fepeloang, ha ho na phapang e atileng taolo ea DAT e boneng lihlopha tse feputsoeng mahala.
Liphetoho tse hlokometsoeng ho boits'oaro le taolo ea DAT li fana ka maikutlo a hore neuroadaptation tsamaisong ea dopamine ea mesoaccumbens e nts'etsapele karabelo ea ho iphepa khafetsa ka lijo tse fumanehang tlasa mathata a lijo. Sena se ts'ehetsa taba ea hore liphetoho tse tšoanang tsa seleng li ka ameha mathata a amanang le ho ja le bingeing.
PMID: 12521926
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