Tlhompho ea moputso le liphatsa tsa lefutso tsa D2 dopamine receptor: Tlhahlobo ea lik'homphieutha tsa bothata ba ho ja li-binge (2008)

Prog Neuropsychopharmacol Biol Psychiatry. 2008 Apr 1; 32 (3): 620-8. Doi: 10.1016 / j.pnpbp.2007.09.024. 

Davis C1, Levitan RD, Kaplan AS, Carter J, Reid C, Curtis C, Patte K, Hwang R, Kennethy JL.

inahaneloang

MORERO:

Boikutlo ba mekhoa ea moputso oa dopamine bo kentsoe kotsing ea mafu a mangata a kelello a kenyeletsang ho nona ho tlola ho tlola. Bopaki bo arohantsoe, leha ho le joalo, mabapi le tataiso ea mokhatlo oa causal. Khopolo-taba e 'ngoe ke hore moputso oa khaello ea moputso ke ona o bakang kotsi, athe ba bang ba pheha khang ea hore moputso o matla oa ho phahamisa moputso o ntlafatsa sepheo sa ho etsa lintho tse khahlisang joaloka ho ja. Ka bomalimabe, lipatlisiso tse nyane tsa batho li koetse lekhalo lipakeng tsa mekhoa ea kelello le ea neurobiological ea ts'ebetso ea moputso oa boko le ts'ebetso. Boithuto bo teng bo rarolle bothata bona ka ho kenya tšebetsong matšoao a kelello le a baeloji tlhoko ea moputso ho protocol ea tlhahlobo.

LITLHAHISO:

Batho ba baholo ba nang le bothata ba ho ja ka mokhoa o batsi (BED) ba ne ba bapisoa le mehlala ea boima bo tloaelehileng le ba mafura a mangata mefuteng e 'meli ea boits'oaro ba moputso mme ba fuoe matšoao bakeng sa matšoao a tšeletseng a mofuta oa DRD2 dopamine receptor gene.

LIKOTSO:

Genotype x Sehlopha sa li-ANOVA se senotse litlamorao tsa bohlokoa le tšebelisano litekanyetsong tsa botho bakeng sa Taq1A. Lithuto tsa BED le tse batenya li tlalehiloe ka kutloisiso e kholo ea kutloelo-bohloko ho feta taolo e tloaelehileng ea boima, empa ke feela ho ba nang le Al1 allele. Re boetse ra fumana hore boholo ba taolo e tloaelehileng ea boima ba 'mele e nang le bonyane khopi e le' ngoe ea T allele ea C957T letšoao e ne e na le lintlha tse ngata tsa kutlo tsa moputso ho feta sehlopha se seng se neng se sa tšoane.

CONCLUSIONS:

Ha ho fanoe ka bopaki bo hokahanyang almanaka ea A1 le letsoalo le fokolang la receptor, kamano e sa lumellaneng e ne e lebelletsoe pakeng tsa mehato ea kelello ea maikutlo a moputso le ho ba teng ha A1 allele. Tlhaloso e le ngoe bakeng sa seo re se fumaneng e ka ba hore barupeluoa ba BED le ba batenya ba na le mofuta o mong o amanang le A1 allele ho hlahisa dopamine e phahameng. Liphumano tsena li na le moelelo lithutong tse tlang tsa liphatsa tsa lefutso tsa BED le botenya, le litloaelo tsa boits'oaro le tsa lithethefatsi tse shebileng maemo ana.

PMID: 18262320

DOI: 10.1016 / j.pnpbp.2007.09.024