Karolo ea Takatso ea Takatso-Peptides e laolang Pathophysiology ea Lithethefatsi: Tlhahiso ea Pharmacotherapy (2014)

CNS Lithethefatsi. 2014 Jun 24.

Engel JA1, Jerlhag E.

inahaneloang

Ho ja le takatso ea lijo ho laoloa ke lihormone tse fapaneng tse potolohang ho kenyelletsa ghrelin le glucagon-like-peptide 1 (GLP-1). Ghrelin, eo boholo ba eona e tsoang ka mpeng, e eketsa lijo, e matlafatsa takatso ea lijo, e matlafatsa takatso ebile e ntša kholo ea li-hormone. Hypothalamic "ghrelin receptors" (GHS-R1A) e na le karolo ea bohlokoa ho taolo ea lijo, empa GHS-R1A le eona e hlahisoa libakeng tse amanang le moputso. GLP-1 e hlahisoa ka maleng a ka maleng le ka bokong ba morao ho arabela ho kenella ka phepo. Hormone ena ea boko ba ka mpeng e fokotsa ho ja ebile e laola glucose homeostasis, haholo-holo ka li-receptors tsa GLP-1 ho hypothalamus le stem stem. Leha ho le joalo, li-receptors tsa GLP-1 li hlahisoa libakeng tse amanang haholo le taolo ea moputso. Ha ho fanoa ka hore taolo ea lijo le tšebeliso ea lithethefatsi e arolelana karoloana e tloaelehileng ea methapo ea kutlo, monyetla oa hore ghrelin le GLP-1 li bapala karolo ea bohlokoa ho taolo ea moputso e lokela ho tsotelloa. Ho joalo, sengoloa sena se etellang pele se hlalosa hore orexigenic peptide ghrelin e kenya tšebetsong khokahano ea moputso oa cholinergic-dopaminergic, karolo ea bohlokoa ea sistimi ea moputso bokong e amanang le matlafatso mme ka tsela eo e eketsa boits'oaro ba boits'oaro ka sistimi ena. Re boetse re lekola karolo ea ponts'o ea ghrelin bakeng sa moputso o susumetsoang ke joala le lithethefatsi tse lemalloang ho tsoa ponong ea bongaka, ea bongaka le ea lefutso. Ntle le moo, liphetho tsa morao-rao tse bonts'ang hore moputso oa taolo ea GLP-1 o bakoang ke joala, amphetamine, cocaine le nicotine litoeba li shebiloe mona. Kamora nako, karolo ea lihormone tse ling tsa taolo ea takatso bakeng sa moputso le ho lemalla e tšohloa hakhutšoanyane. Ka kakaretso, lintlha tsena li fana ka maikutlo a hore li-receptors tsa ghrelin le GLP-1 e kanna ea ba liphofu tse ncha bakeng sa nts'etsopele ea kalafo ea litlhare tsa joala le ts'ebeliso ea lithethefatsi.