Serotonin 5-HT2C Receptor Activation e thibela ho ba le mekhoa e metle le ho matlafatsa le ho khothaletsa lijo tse phahameng tsa lijo (2018)

Front Pharmacol. 2018 Jul 27; 9: 821. Doi: 10.3389 / fphar.2018.00821.

Theko AE1, Anastasio NC1,2, Stutz SJ1, Hommel JD1,2, Cunningham KA1,2.

inahaneloang

Bothata ba ho ja (BED) bo tšoauoa ka ho ja lijo tse amanang le ho ja lijo tse matla le tse amanang le moputso. Ts'ebetso ea serotonin (5-HT) 5-HT2C receptor (5-HT2CR) e hatella lijo le litloaelo tse amanang le moputso ka hona e ikemiselitse ho laola BED. Phuputso ena e ile ea lekola litlamorao tsa 5-HT2CTs'ebetso dessyecik 5-HT e khethang2CR agonist WAY163909 mabapi le boits'oaro bo amanang le ho ja ho litloholo tsa banna ba baholo ba Sprague-Dawley. Litekanyetso tse tlase tsa WAY163909 (1.0, 2.0 mg / kg) li hatelletse lijo tse nang le mafura a mangata (HFF), empa eseng lijo tse tloaelehileng. WAY163909 (1.0 mg / kg) le mohoebi ea fumanehang a arabela bakeng sa li-pellets tse itlhommeng pele tsa HFF ho ​​li-ratiine tsa boikemisetso tse tsitsitseng le tse tsoelang pele, tse bonts'ang hore 5-HT2CTs'ebetso ea R e hatella thepa e matlafatsang le e susumetsang ea HFF, ka ho latellana. Liphumano tsena li fana ka maikutlo a hore ts'ebetso ea 5-HT2CR e kanna ea sebetsa hantle ho hatella ho itlopa joala ho bakuli ba nang le BED dessyecik khatello ea matlafatso ea thepa ea HFF. Mosebetsi ona o tšehetsa lithuto tsa nako e tlang tse lebisitsoeng ho 5-HT2CR kalafong ea BED.

LINKOTSO:

5-HT2C receptor; ho itlopa joala; lijo tse nang le mafura a mangata; tšusumetso; serotonin

PMID: 30100875

PMCID: PMC6072841

DOI: 10.3389 / fphar.2018.00821