ACS Chem Neurosci. 2019 Apr 1. Doi: 10.1021 / acschemneuro.8b00601.
John S, Galbraith J, Kalipari E, Khokahanya PJ.
inahaneloang
Boitsebiso bo bokelletsoeng bo tsoang lithutong tsa bongaka le tsa pelehi bo fana ka maikutlo a hore bokhobeng ba lithethefatsi le litereke tsa ho nona haholo, joalo ka botenya le bothata ba ho ja ka mokhoa o feteletseng (BED), ho na le ho se leka-lekane lipotolohong tse bohlokoa bakeng sa ho susumetsa, moputso oa ho se sebetse hantle, ts'ebetso ea botsamaisi le boitšoaro . Khubu ea li-pathologies tsena le sehlooho se pharaletseng sa tlhahlobo ena ke ho amoheloa ha dopamine (DA) le glutamate (Glu) ka har'a tsela ea mesolimbic. Sehlopha I metabotropic glutamate receptors li hlahisoa haholo litseleng tsa mesolimbic mme li behiloe maemong a bohlokoa ho fetolela pherekano ho polasetiki ea synaptic le neurotransmitter e nkoang e le tlhekefetso ea lithethefatsi, botena le BED. Ts'ebeliso ea li-modulators tsa li-allosteric of group I metabotropic glutamate receptors (mGluRs) li ithutile ka bokhoba ba lithethefatsi, kaha li fana ka menyetla e 'maloa ho feta li-genthale tsa setso. Leha ho le joalo, ha li sa lokela ho ithutoa ka botenya kapa BED. Ka karohano e kholo lipakeng tsa li-neurocircuitry tse kenelletseng ts'ebelisong ea lithethefatsi le mathata a ho ja, sehlopha sa li-mGluR se ka fana ka lipheo tse ncha tsa botenya le BED.
PMID: 30933466
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