Ho jella sham ea sucrose ka lenane la ho itlosa bolutu ho hlahisa dopamine hangata mme ho felisa karabo ea acetylcholine satiety (2006)

Khopolo-taba. 2006; 139 (3): 813-20. Epub 2006 Feb 7.

Avena NM1, Rada P, Moise N, Hoebel BG.

inahaneloang

Ho ntsa tharollo ea tsoekere lenaneong la nakoana ho ka khothaletsa ho opeloa ke tsoekere le ho etsa hore motho a be le litlamorao ha a ntse a ntsha dopamine khafetsa joalo ka sethethefatsi sa tlhekefetso. Ho nahanoa hore tatso e monate e le 'ngoe e lekane bakeng sa phello ea likhoto tse nyane. Khopolo-taba ea hore acetylcholine e bokellaneng ea nucleus e bapala karolo ea katleho, ho boleloa ka matla hore ho hloekisa likarolo tsa mpa ho tla liehisa ho lokolloa ha acetylcholine. Likhoto tse nang le li-gistric fistulas le li-shaft tsa nucleus tsa li-nucleus li fepeloa 12 h letsatsi le leng le le leng. Nakong ea hora ea pele, li-fistulas li ne li buletsoe sehlopha sa phepelo ea sham mme se koaletsoe sehlopha sa phepelo ea sebele, mme 10% sucrose ke eona feela mohloli oa lijo. Bakeng sa 11 h e setseng, lijo tse nang le methapo ea metsi li ne li fumaneha hammoho le 10% sucrose ho fana ka phepo e nepahetseng. Litekong tsa Microdialysis nakong ea lijo tsa tsoekere tsa pele ka matsatsi a 1, 2 le 21, dopamine ea extracellular e eketsehile bonyane 30% letsatsi le leng le le leng ka lihlopha tsena ka bobeli. Acetylcholine le eona e ile ea eketseha nakong ea lijo tse tsoekere bakeng sa liphoofolo tse jang hantle, empa eseng nakong ea ho fepa sham. Qetellong, tatso ea tsoekere e ka eketsa li-dopamine tsa extracellular ka har'a li-nucleus tsa khubung ntle le ho hloleha ho liphoofolo ka mokhoa oa ho ja o bakang ho itlopa le ho ts'epa tsoekere. Nakong ea ho fepa sham, letšoao la satiation la acetylcholine le felisoa, 'me liphoofolo li noa ho feta. Liphumano tsena li ts'ehetsa maikutlo a hore dopamine e lokolloa khafetsa ho arabela tatso ha e itlopa lijo tse monate, mme phello ea acetylcholine satiety e fokotsoa haholo ka ho hlatsoa; hona ho ka sebetsa ho bulimia mothosa ho batho.

PMID: 16460879

DOI: 10.1016 / j.neuroscience.2005.12.037