Psychopharmacology (Berl). 2016 Aug 18.
Eikemo M1,2,3, Loseth GE4, Johnstone T.5, Gjerstad J6,7, Lenaneo la Willoch F.7, Leknes S4,8.
inahaneloang
LITLHAHISO:
Mefuta ea pente e totobatsa karolo ea bohlokoa ea μ-opioid receptor (MOR) ho bonts'a tšebeliso ea lijo tse monate. Leha ho le joalo, ho batho, litlamorao tsa tšusumetso ea MOR ho ja le ho rata lijo li ntse li sa hlaka.
LIPOTSO:
Mona, re ile ra leka tatso e monate ea thabo bathong ba latelang manolo a lithethefatsi tsa MOR. Re fane ka maikutlo a hore boits'oaro bo laoloang ke tsamaiso ea MOR ea morao-rao bo tla ntlafatsoa ke agonism ea MOR mme e fokotsehe ka ho hanyetsa. Tumellanong le liphetho tsa litente, re ne re lebelletse litlamorao tse matla ka ho fetisisa tsa lithethefatsi bakeng sa tšusumetso e ntle ka ho fetisisa ea khalori e phahameng. Joalo ka ha maikutlo a monate a nkoa a kheloha ke batho ba bangata (ba bitsitsoeng ba sa rateng monate), re boetse re lekotse hore na mokhabo-puo oa MOR o ama litekanyetso tsa monate oa metsi a sucrose ka mokhoa o fapaneng ho latela boleng ba sepheo-phetho le sepheo.
LITLHAHISO:
Phuputsong e fetelletseng ea kelello ea kelello ea kelello, banna ba phetseng hantle ba 49 ba ile ba etsa tatso e monate ea tatso e latelang taolo ea mahlo a morao ea MOR agonist morphine, placebo, le opioid antagonist naltrexone.
LIKOTSO:
Ha hypothesized, MOR e hlohlelletsa morphine e ile ea eketsa monate oa tharollo tse ntle ka ho fetisisa tsa bohlano, ntle le ho ntlafatsa monate oa tharollo ea sucrose e tlase. Bakeng sa ho hanyetsa opioid, mokhoa o fapaneng o ile oa bonoa bakeng sa seno se monate feela. Litlamorao tse bonoang ke lithethefatsi ka lebaka la monate oa seno se monate ka ho fetisisa se ne se sa fapana lipakeng tsa ba ratang monate le ba sa li rateng.
CONCLUSIONS:
Litlamorao tsa phetoho ea kalafo ea agonist le antagonist e lumellana le lipatlisiso tsa litheko tse bontšang hore manonyeletso a MOR a ama haholo lijo tse nang le khalori e phahameng haholo. Re hakanya hore Sisteme ea MOR e khothaletsa ho pholoha ka karolo e 'ngoe ka ho eketsa concordance lipakeng tsa sepheo (caloric) le boleng ba tšusumetso ea lijo, e le hore boits'oaro ba ho iphepa bo shebane haholo le lijo tse ruileng haholo tse fumanehang.
LINKOTSO:
Lijo; Motho; Morphine; Naltrexone; Sistimi ea Opioid
PMID: 27538675
DOI: 10.1007 / s00213-016-4403-x
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