Motsoako oa Matšoao-O Kopantsoeng le Motsoako oa 1 Agonist RO5256390 Libaka tse qobelloang, ho ja Lijo Tse Ngata ho Rats (2016)

Neuropsychopharmacology. 2016 Oct 6. Doi: 10.1038 / npp.2016.233. [Epub pele ho khatiso]

Ferragud A1, Howell AD1, Moore CF1, T TL1, Hoener MC2, Sabino V1, Cottone P1.

inahaneloang

Ho ja ka mokhoa o qobelloang, ho itlhahisa ka lijo tse matlafatsoang ke karolo ea mantlha ea mefuta e meng ea botenya le mathata a ho ja, hammoho le bokuli bo sa ntsaneng bo khothalletsoa ke bokhoba ba lijo.. Trace Amine-Associated Receptor 1 (TAAR1) ke receptor e bolokiloeng haholo ea G-protein e kopantsoeng ke li-amine tsa endo native trace. Li-agonists tsa TAAR1 li bontšitsoe ho fokotsa litla-morao tsa boits'oaro ba lithethefatsi tsa tlhekefetso ka liketso tsa bona tsamaisong ea mesocorticolimbic. Thutong ena, re fane ka maikutlo a hore TAAR1 e ka bapala karolo ea phephetso e kang ho ja; re lekile tlhahlobo ena ka ho hlahloba litlamorao tsa agonist ea TAAR1, RO5256390, ka mekhoa e mengata e amanang le phepo e fetisisang e kenyellelitseng phokotso ea ho fumana lijo tse matlafatsoang haholo ho likhoto.

Liphetho tsa rona li bonts'a hore RO5256390 e thibetse ho ja-joaloka ho ja likhoto lijong tsa 1 h / letsatsi bakeng sa lijo tse tsoekere tse tsoekere haholo. E lumellana le phello e ikhethileng ea ho khetha, kalafo ea lithethefatsi ka mokhoa o khetholloang e fokotsitse sekhahla le lijo tse fumanehang habonolo, empa ha se a ama ho ja lijo tsa mantlha kapa tšitiso ea lijo ka lebaka la tšenyo ea maemo a tloaelehileng a chow kufat.

Ntle le moo, RO5256390 e koalehile ka mokhoa o ts'oanang le oa ho ja ha lijo tse matlafatsang li nehelloa ka phapusing ea lebokose le bobebe / le lefifi, 'me la thibela maemo a monate a lijo tse fumanehang habonolo le boits'oaro bo bobebe ba ho batla lijo ka tatellano ea bobeli. kemiso ea ho matlafatsa. Phekolo ea lithethefatsi e ne e sena tšusumetso ho e kang boits'oaro bo kang bo tšoenyang kapa ba khatello ea maikutlo, mme ha e a ka ea ama ts'ebetso ea taolo ho e ngoe ea liteko. Habohlokoa, likhoto tse senotsoeng ke lijo tse matlafatsoang li bonts'itse li fokotsehile tsa TAAR1 maemong a mongobo oa pele oa kalafo (mPFC), le RO5256390 microinfuse ho infralimbic, empa eseng prelimbic, subregion ea mPFC e fokotsitse ho ja-joalo ka lijo. Ka kakaretso, liphetho tsena li fana ka bopaki bakeng sa agonism ea TAAR1 joalo ka kalafo ea bongaka e rarahaneng bakeng sa ho ja ka mokhoa o qobelloang.

PMID: 27711047

DOI: 10.1038 / npp.2016.233