Lintlha-khōlō Tsa
- • Ho kengoa tšebetsong ha li-neuron tsa LH GABAergic ho hlahisa boits'oaro bo botle ba takatso le boits'oaro
- • Ho felisoa ha lisele tsa LH GABAergic ho hlahisa boima ba 'mele, ts'ebeliso, le tšusumetso
- • Li-subset tsa LH GABAergic li na le lisele tse fapaneng le lisele tsa MCH le Orx
- • Ka vivo Ca2+ monahano o senola marang-rang a nang le takatso ea lijo le a kopantsoeng
Ho hlophisa hantle litloaelo tsa boits'oaro tse rarahaneng, joalo ka ho lelekisa le ho ja lijo, ho bohlokoa bakeng sa bophelo ba setho. The lateral hypothalamus (LH) ke sebaka sa neuroanatomical se hlokahalang bakeng sa boits'oaro bo botle le boits'oaro, empa hore na li-neurons tse kahare ho LH li kenya letsoho lits'ebetsong tsena tse kopaneng ha li tsejoe. Mona, re bonts'a ts'usumetso ea optogenetic e ikhethileng ea seterata se hlalositsoeng ka molek'hule sa LH GABAergic (Tse-expressing) li-neurone li ntlafatsa boits'oaro bo khotsofatsang le boits'oaro, athe ho tlosoa hoa liphatsa tsa lefutso tsa li-neuron tsena ho fokolisitse li-phenotypes tsena. Ntle le moo, palo ena e lebisitsoeng ea LH e fapane le lisele tse nang le li-neuropeptides tse amanang le ho fepa, hormone e shebaneng le melanin (MCH), le orexin (Orx). Re sebelisa vivo calcium imaging ka litoeba tse itšoarang ka bolokolohi ho rekota matla a ts'ebetso ho tsoa liseleng tse makholo, re ile ra supa li-neurone tsa LH GABAergic tse khethang likarolo tsa boits'oaro kapa tsa boitšepo, empa e le ka seoelo ka bobeli. Ts'ebetso ena ea boits'oaro bo laoloang ka thata, empa e hokahane haholo ka tsela eo e ka arohana maemong a lisele.
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