Maikutlo: Ho ithuta ho senola ho hloka taolo ho dopamine ho ba nang le lithethefatsi tsa ho becha. Hape, potso e totobetseng: Haeba bats'oari ba pathological ba na le matšoao a tšoanang le bokhoba ba lithethefatsi, ho tla joang hore batho ba lemaletseng litšoantšo tsa bootsoa ba se ke ba ba le mathata a tšoanang? Ntho e 'ngoe e khahlisang thutong ena ke theknoloji ea ho lekanya dysamine ts'ebetsong ka tlhahlobo ea mali.
Neuropsychobiology. 2011;63(3):154-9. doi: 10.1159 / 000321592.
Martini C.1, Daniel S, Qalase M, Panighini A, Carlini M., Mokha oa Trincavelli, Cesari D., Ka Pozzo E, Golia F., Dell'Osso L.
inahaneloang
LITLHAHLOOHO / LIPHELO:
Tšebelisano 'moho le tšebetso lipakeng tsa A (2A) li-adenosine receptors le D (2) li-receptors tsa dopamine li kentse letsoho ho pathophysiology ea mathata a taolo ea ts'usumetso. Morero oa thuto ena e ne e le ho sebelisa li-membrane tsa platelet ho lekola kamano ea li-adenosine receptor le letsoalo ho bakuli ba anngoeng ke ho becha ha methapo ea methapo (PG; e khethiloeng e le bothata bo itseng ba taolo ea tšusumetso) mabapi le ba lithuto tsa taolo.
LITLHAHISO:
Bakuli ba leshome le metso e 'meli ba PG ba se nang lithethefatsi le lilemo tse 12- le lits'oants'o tse lumellanang le thobalano li ngolisitsoe thutong. PG e fumanoe ho ea ka Structured Clinical Interview ea DSM-IV - Patient Version 2.0 le Screen ea South Oaks Gambling. Likarolo tse tlamang tsa adenosine receptor (2A) li ile tsa hlahlojoa ho sebelisoa [[3] H] ZM (241385) tlhahlobo e tlamang; kamano le botenya (B (max)) li ne li khethoa ka lithuto tsa tlamo tse tlamang tse nang le lera la platelet.
LIKOTSO:
Adenosine receptor binding e kopantsoeng le A (2A) e fumanoe e phahame haholo ho bakuli ba anngoeng ke PG ho feta lithutong tse phetseng hantle; ka lehlakoreng le leng, ha ho phapang e kholo ho B (max) e hlokometsoeng pakeng tsa lihlopha tsa 2.
CONCLUSIONS:
Adenosine receptor e tlamang ea kopaneng liphutheloana tse tsoang ho bakuli ba PG mabapi le taolo ea taolo e bonts'a ka lekhetlo la pele phetoho litekanyetsong tsa adenosine receptor, mme e fana ka maikutlo a ho nka karolo ha tsamaiso ea adenosine ho lefu lena. Hyperacaction e bontšitsoeng pejana ea sisteme ea dopamine ho PG e ka fetolela adenosine receptor ea A (2A), e ts'ehetsa karolo ea receptor ena e le letšoao la ho se sebetse ha dopamine. Hobane ha ho khonehe ho lekanya ka kotloloho li-D (2) dopamine receptor liphatlalatsong tsa batho, lintlha tsena li bohlokoa haholo ho khethollo ea dopamine dysfunction.
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