Tsela e khethehileng bakeng sa li-receptor tsa dopamine D4 bakeng sa ho fokotsa nako ea tebello ea moputso mochine oa slot machine (2014)

Biol Psychiatry. 2014 May 15; 75 (10): 817-24. Doi: 10.1016 / j.biopsych.2013.08.026. Epub 2013 Oct 4.

Pocker PJ1, Le Foll B2, Rogers RD3, Winstanley CA4.

inahaneloang

LITLHAHISO:

Lits'oants'o tse lemohileng mabapi le sephetho sa papali ea chelete li beha kotsing ea ho becha. Re sebelisa mosebetsi oa mochini oa rat slot (rSMT), re kile ra supa hore nonspecific D₂ agonist quinpirole e ntlafatsa litebello tse fosahetseng tsa moputso litekong tse haufi tsa ho hloloheloa, ho fana ka maikutlo a karolo ea bohlokoa bakeng sa lelapa la D₂ receptor ho kenella ts'ebetsong. Ho tseba hore na ho na le karolo efe ea "receptor subtype" e ka thusang nts'etsopele ea kalafo bakeng sa papali e qobelloang ea slot

LITLHAHISO:

Liroto tse telele tse mashome a mararo a metso e 'meli tsa banna li ithutile rSMT. Mabone a mararo a bonesang a ka beoa ho tima kapa ho tima. Ho ne ho saennoe win haeba mabone ohle a mararo a ne a ka kenngoa, athe mabone a mang a khanya a ne a lahlile. Likhoto li ile tsa khetha pakeng tsa ho arabela lever ea pokello, e ileng ea fana ka li-pellets tsa tsoekere tsa 10 litekong tsa win empa 10-nako ea bobeli ea kotlo litekong tsa tahlehelo, kapa ho qala teko e ncha. Ts'ebetso e ile ea hlahlojoa kamora ts'ebetso ea tsamaiso ea li-D₂, D₃ le D₄ receptor ligands tse khethiloeng.

LIKOTSO:

Mohanyetsi ea khethiloeng oa D₂ L-741,626, mohanyetsi oa D₃ SB-277011-A, le D₃ agonist PD128,907 ha ba na phello. Ka lehlakoreng le leng, khetho ea D₄ agonist PD168077 e ile ea etsisa litlamorao tsa quinpirole, ea eketsa likarabo tse fosahetseng litekong tsa nonwin, athe mohanyetsi oa D₄ L-745,870 o ntlafalitse sekhahla. L-745,870 hape e ne e le mohanyetsi feela ea neng a ka fokotsa litlamorao tse mpe tsa quinpirole.

CONCLUSIONS:

Dopamine D₄ receptor e kenella ka mokhoa o tebileng ho tšoaea tebello ea moputso ho RSMT. Bokhoni ba L-745,870 ba ho fokotsa tlhahlobo ea tahlehelo joalo ka katleho e fana ka maikutlo a hore bahanyetsi ba D₄ ba ka sebetsa hantle ho phekoleng bothata ba seteraeke.

© 2013 Mokhatlo oa Biology Psychiatry E hatisitsoeng ke Society of Biological Psychiatry Litokelo tsohle li bolokiloe.