Psychopharmacology (Berl). 2015 Jun 20.
Janssen LK1, Sescousse G, Hashemi MM, Timmer MH, Ter Huurne NP, Geurts DE, Ho fepa R.
inahaneloang
RATIONALE:
Ho becha ka tsela ea tlhaho ho tsamaisana le tlhekefetso ea phetisetso ea dopamine, haholo khaello ea dopamine D2-receptor, le bofokoli ba ho ithuta hape. Ntle le moo, litlaleho tsa thuto ea morao-rao li fana ka maikutlo a karolo ea bohlokoa bakeng sa dopamine ho ithuteng boithuto. Leha ho le joalo, ha ho na bopaki bo matla ba khokahano e tobileng pakeng tsa dopamine, ho khutlela morao thutong le papali ea kelello.
MORERO:
Morero oa thuto e teng hona joale ke ho fapanyetsana dopamine, ho fetolela ho ithuta hape le papali ea papali ea methapo.
LITLHAHISO:
Mona, re lekola khopolo-taba ea hore papali ea chelete e tsamaisana le mathata a amanang le dopamine ka ho ithuta ho tsoa moputsong le kotlong ka ho batlisisa litlamorao tsa dopamine D2-receptor antagonist sulpiride (400 mg) mabapi le moputso-le kotlo e ipapisitseng le thuto ho bapalami ba 18 ba sa sebetseng. le litsamaiso tse 22 tse phetseng hantle, ho sebelisoa moralo o laoloang ke "placebo", o foufetseng habeli, o leka-lekaneng.
LIKOTSO:
Tumellanong le lithuto tsa pejana, blockade ea li-receptor tsa D2 tse nang le moputso o sotlehileng oa sulpiride le phapanyetsano ea ho khutlisa kotlo ho taolo. Ka lehlakoreng le leng, sulpiride e ne e se na litlamorao tse tobileng ho batho ba bechang.
QETELLO:
Lintlha tsena li bonts'a hore ho becha ha 'mele ho amanang le dopamine e amanang le dopamine ho khutlisa ho ithuta ho tsoa moputsong le kotlong.