Tlhaloso e sa tloaelehang ea moputso khahlanong le kotlo ea ho ithuta ka dopamine D2-receptor mohanyetsi litšoantšong tsa papali ea papali ea chelete (2015)

Psychopharmacology (Berl). 2015 Jun 20.

Janssen LK1, Sescousse G, Hashemi MM, Timmer MH, Ter Huurne NP, Geurts DE, Ho fepa R.

inahaneloang

RATIONALE:

Ho becha ka tsela ea tlhaho ho tsamaisana le tlhekefetso ea phetisetso ea dopamine, haholo khaello ea dopamine D2-receptor, le bofokoli ba ho ithuta hape. Ntle le moo, litlaleho tsa thuto ea morao-rao li fana ka maikutlo a karolo ea bohlokoa bakeng sa dopamine ho ithuteng boithuto. Leha ho le joalo, ha ho na bopaki bo matla ba khokahano e tobileng pakeng tsa dopamine, ho khutlela morao thutong le papali ea kelello.

MORERO:

Morero oa thuto e teng hona joale ke ho fapanyetsana dopamine, ho fetolela ho ithuta hape le papali ea papali ea methapo.

LITLHAHISO:

Mona, re lekola khopolo-taba ea hore papali ea chelete e tsamaisana le mathata a amanang le dopamine ka ho ithuta ho tsoa moputsong le kotlong ka ho batlisisa litlamorao tsa dopamine D2-receptor antagonist sulpiride (400 mg) mabapi le moputso-le kotlo e ipapisitseng le thuto ho bapalami ba 18 ba sa sebetseng. le litsamaiso tse 22 tse phetseng hantle, ho sebelisoa moralo o laoloang ke "placebo", o foufetseng habeli, o leka-lekaneng.

LIKOTSO:

Tumellanong le lithuto tsa pejana, blockade ea li-receptor tsa D2 tse nang le moputso o sotlehileng oa sulpiride le phapanyetsano ea ho khutlisa kotlo ho taolo. Ka lehlakoreng le leng, sulpiride e ne e se na litlamorao tse tobileng ho batho ba bechang.

QETELLO:

Lintlha tsena li bonts'a hore ho becha ha 'mele ho amanang le dopamine e amanang le dopamine ho khutlisa ho ithuta ho tsoa moputsong le kotlong.