Liphetolelo tsa Striatal Responses ho Haufi le Liphello Tse Ntle ho Batho ba Bapala Liphoso (2016)

LITABA: Ke fumana ho le thata ho lumela hore dopamine ha e amehe, joalo ka ha bangoli ba fana ka maikutlo. Pele, ba sebelisitse mohanyetsi oa D2. Ho thoe'ng ka ts'ebetso ea D1 e leng senotlolo sa ho matlafatsa? Hape, rea tseba hore ts'ehetso e kenyelletsa PFC le lisebelisoa tsa amygdala glutamate tse sebetsang ho NaC. Na ke feela glutamate e nolofalletsang li-receptor tsa D1? Empa lekhalo le leholo la mabaka ke lena: ha a ntse a le haufi le ho fosoa ke "MOTSOALLE O MANG" ho batho ba lemaletseng papali ea chelete, haufi le liphoso ha ho hlile ha ho joalo moputso - ho hapa ke. Dopamine e theoha ha litebello li sa fihlelloe. Tebello ntlheng ena ea hlola.


Guillaume Sescousse1,2, Lieneke K Janssen1,2, Mahur M Hashemi1Nako ea Monique HM1,3,4, Dirk EM Likokoana-hloko1,2, Niels P ter Huurne1,2, Luke Clark3,4 le Roshan Pholisa1,2

  1. 1Setsi sa Donders bakeng sa Brain, Cognition and Behavior, Radboud University, Nijmegen, Netherlands
  2. 2Lefapha la Psychiatry
  3. 3Lefapha la Neurology, Setsi sa Bongaka sa Radboud University, Nijmegen, Netherlands
  4. 4Setsi sa Patlisiso ea Papali ea Papali ea chelete ho UBC, Lefapha la Psychology, Univesithi ea British Columbia, Vancouver, British Columbia, Canada

Sengoloa: Dr G Sescousse, Setsi sa Donders bakeng sa Cognitive Neuroimaging, Setsi sa Donders bakeng sa Brain, Cognition and Behavior, Radboud University, Kappitelweg 29, PO Box 9101, Nijmegen 6500 HB, the

Netherlands, Tel: + 31 0 24 36 10618, Fax: + 31 0 24 36 10989, E-mail: [imeile e sirelelitsoe]

inahaneloang

Likhau tse haufi le lipapali tsa papali ea papali ea chelete li lahleheloa ke liketsahalo tse atamelang ho win. Metsoako e haufinyane e kile ea bontšoa ho hira libaka tse amanang le moputso tse kenyelletsang moputso ho kenyeletsa le moea o kenang kahare, le ho matlafatsa boitšoaro ba papali ea chelete, bao ho thoeng ke ka ho etsa hore ho be le taolo e mpe. Ka lebaka la hore batho ba betšang ba kotsing ea ho ba le tsebo e joalo ea boiketsetso, boitšoaro ba bona bo phehellang ba papali ea chelete bo ka bakoa ke ho ba le maikutlo a ntlafalitsoeng a boits'oaro le liphoso tse haufi. Ntle le moo, lithuto tsa liphoofolo li bonts'itse hore likarabo tsa boits'oaro liketsahalong tse haufi le tse sa fetosoang li natefeloa ke dopamine, empa tšusumetso ena ea dopaminergic ha e so lekoe ho batho. Ho etsa lipatlisiso ka litlatsetso tsena, re ile ra hira basomi ba 22 ba methapo ea kutlo le ba laoloang ba phetseng hantle ba 22 ba neng ba bapala mosebetsi oa ho fana ka lits'oants'o tse haufi le tseo re li entseng nakong e fetileng. Morupeluoa e mong le e mong o ile a bapala mosebetsi oo habeli, hanngoe ka tlasa placebo mme a le kaholimo ho dopamine D2 receptor antagonist (sulpiride 400 mg), ka sebopeho se sa boneng habeli, se sa lumellaneng. Barupeluoa ba ile ba botsoa ka tšusumetso ea bona ea ho tsoela pele ho becha nakong eohle ea mosebetsi. Hohle bankakarolo bohle ba bile le sepheo se matla sa hore ba tsoele pele ho becha le ho fana ka likarabo tse eketsehileng ho bapisoa le maemo a felletseng. Ka bomalimabe, bashebelli ba 'mele ba ile ba bonts'a likarabo tse ntlafalitsoeng ho tsa bosholu ha li bapisoa le taolo. Liphapang tsena tsa sehlopha ha lia ka tsa bonoa ka mor'a sephetho sa win. Ho fapana le tšibollo ea rona, sopidide ha e a ka ea fetisa modumo o mong le o mong o tšepahalang oa likarabo tsa boko ho liphoso tse haufi. Ka bobeli, liphetho tsa rona li bonts'a hore basomi ba methapo ea methapo ea methapo ba holofalitse likarabo tsa boko ho liphosong tse haufi, tse ka tlatsetsang ho phehelleng boitšoaro ba bona ba papali ea papali ea chelete. Leha ho le joalo, ha ho na bopaki ba hore likarabo tsena li susumetsoa ke dopamine. Liphetho tsena li na le moelelo bakeng sa kalafo le taolo ea papali ea chelete.