Boin Behav. 2019 Mar; 9 (3): e01239. Doi: 10.1002 / brb3.1239.
Møller A1,2, Rømer Thomsen K3, Brooks DJ1,2,4, Mouridsen K2, Blicher JU2, Hansen KV1, Lou HC2.
inahaneloang
SELELEKELA:
Re kile ra bonts'a hore tšebelisano lipakeng tsa medial pele le parietal cortices e thusa haholo ho nts'etsapele tlhokomeliso ka ho hokahanya oscillations mokheng oa gamma. Khokahano ea li-oscillations tsena e fetoloa ka tokollo ea dopamine. Ka lebaka la hore Oscillations e joalo e bakoa ke ho ts'oaroa ha lisele tsa GABA lisele tse nyane, hoa thahasellisa ho tseba hore na tsamaiso ea dopaminergic e laola tokollo ea GABA ka kotlolloho libakeng tsa cortical paralimbic. Mona, re leka mohopolo oa hore tsamaiso ea Gaba-ergic system ke dopaminergic system e kenella mekhoeng ea papali ea chelete e bakang boits'oaro bo bobe ba ho lematsa.
LITLHAHISO:
[11 C] Ro15-4513 PET, letšoao la benzodiazepine α1 / α5 ho fumaneha ha li-receptor ho GABA receptor complex, e ne e sebelisetsoa ho bona liphetoho maemong a synaptic GABA kamora litekanyetso tsa molomo tsa 100mg L-dopa thutong e laoloang habeli ka mahlo ea banna ba nang le bothata ba papali ea chelete. (N = 10) le taolo ea banna e phetseng hantle e lumellanang le lilemo (N = 10).
LIKOTSO:
Phokotso e bolelang ea "cortical grey" taba ea ho fumaneha ha receptor ea GABA / BDZ e bakiloeng ke L-dopa e ile ea fokotsoa haholo sehlopheng sa bothata ba papali ea chelete ha e bapisoa le sehlopha sa taolo e phetseng hantle (p = 0.0377).
CONCLUSIONS:
Liphumano tsa rona li bonts'a hore: (a) Dopamine ea Exo native dopamine e ka susumetsa tokollo ea GABA ea synaptic ka taolo e phetseng hantle. (b) Tokollo ena e bonoa libakeng tse ka pele tsa banna ba nang le bothata ba papali ea chelete, mohlomong e ba bakelang tahlehelo ea taolo ea thibelo. Sena se fana ka maikutlo a hore taolo ea dopamine e sa sebetseng ea tokollo ea GABA e ka kenya letsoho bothateng ba papali ea chelete le papali ea chelete.
LINKOTSO: GABA; PET; Ro15-4513; dopamine; bothata ba ho becha; boitaolo
PMID: 30788911
PMCID: PMC6422713
DOI: 10.1002 / brb3.1239
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