Phetoho e tsitsitseng ea opioid e fokolang ka mor'a hore e fanoe ka Khotsofalo ea Liphoofolo ka Botlalo (2015)

Neuropsychopharmacology. 2015 Nov 10. Doi: 10.1038 / npp.2015.340.

Mick I¹, Lisa J¹, Ramos AC^1,2, Litutu PR^1,3, Erritzoe D¹, Colasan A^1,3,4, Gunn RN^1,4, Rabiner EA^4,5, Fumana GE⁴, Waldman AD⁶, Parkin MC⁷, Brailsford AD⁷, Galduróz JC², Bowden-Jones H⁸, Clark L⁹, Nutt DJ¹, Lingford-Hughes AR¹.

inahaneloang

Ho betla papali ea kelello ke bokuli ba kelello le tšebeliso ea boitšoaro ea pele e amoheloang, e tšoanang le mathata a ts'ebeliso ea lithethefatsi empa ntle le litlamorao tse mpe tsa liphetoho tsa kelello tse amanang le lithethefatsi. Pathophysiology kahare ho sistimi ea li-receptor ea opioid e ntse e hlokomeleha haholoanyane ka ts'ebeliso ea lithethefatsi, ka ho fumaneha ho holimo ho mu-opioid receptor (MOR) ho tlalehiloe ka joala, cocaine le ts'ebeliso ea opiate. Tšusumetso, e leng lebaka le behang likotsi litlatsetsong, le eona e fumanoe e amana le ho fumaneha ho phahameng ha MOR.

Morero oa thuto ena e ne e le ho supa phumaneho ea MOR ea mantlha le tokollo ea opioid ea basesane ho tsa ho becha ha li-pathological (PG) sebelisa [¹¹C] carfentanil PET e nang le phephetso ea amphetamine ea molomo. Baithaopi ba 14 ba PG le 15 ba phetseng hantle (HV) ba bile habeli [¹¹C] carfentanil PET e lekola, pele le kamora tsamaiso ea molomo ea 0.5 mg / kg ea d-amphetamine. Phetoho ho [¹¹C] carfentanil e tlamang pakeng tsa scans tsa motheo le tsa post-amphetamine (ΔBP_ND) e ile ea hlahlojoa libakeng tsa 10 tsa phaello (ROI). Phumano ea MOR e ne e sa fapana lipakeng tsa lihlopha tsa PG le HV. Joalokaha re bone pejana, phephetso ea amphetamine ea molomo e lebisitse ho fokotsa haholo ho [¹¹C] carfentanil BP_ND ho 8 / 10 ROI ho HV.

PG e bontsitse blunting ea bohlokoa ea tokollo ea opioid ha e bapisoa le HV. PG e boetse e bonts'a li-amphetamine tse khothatsang tse hlasimolohileng le ho ba seli ha li bapisoa le HV. Tlhahlobo e hlalosang e senotse hore ho susumetsoa ka nepo ho amana hantle le motheo oa caudate BP_ND ka PG feela. Boithuto bona bo fana ka bopaki ba pele ba ho lokolloa ha moriana oa opioid o tsoang ho PG. Seo re se fumaneng se lumellana le bopaki bo ntseng bo eketseha ba hore tšebeliso ea li-opioid tsa mehleng ea khale li ka ba le karolo ea bohlokoa ho pathophysiology ea lithethefatsi..