J Psychopharmacol. 2015 Jul 7. pii: 0269881115592338. [Epub pele ho khatiso]
Zack M1, Boileau I2, Tefo D2, Chugani B2, Lobo DS2, Houle S2, Wilson AA2, Warsh JJ2, Kish SJ2.
inahaneloang
Ho ferekana ha pelo le hypothalamic pituitary axis (HPA) ho hlokometsoe ho batho ka bomong bao e leng li-pathological gambler (PGs). Sena se ka 'na sa bakoa ke ho pepesetsoa ho becha ho sa feleng. Karabo ho amphetamine (AMPH) e kanna ea senola litšitiso tse joalo ha e ntse e laola likarabelo tse nang le maemo a fapaneng a papali ea chelete papaling ea li-PGs vs..
Phuputso ena e ile ea lekanya tekanyo ea pelo (HR), khatello ea mali ea systolic (SBP) le khatello ea mali ea diastolic (DBP) le plasma cortisol e latelang AMPH (0.4 mg / kg) ho li-PG tsa banna (n = 12) le HCs (n = 11) ba tlhatlhobo ea positron emission tomography (PET). Mosebetsi oa Stop Signal o thusitse tlhahlobo ea khokahano lipakeng tsa boikoetliso ba 'mele le boits'oaro. Litlamorao tsa tlhahlobo ea mekhoa
Likarabo tsa li-PG ho AMPH li ne li fapane le tsa HCs ho index e ngoe le e ngoe.
Li-PG li bonts'itse phetoho e phehellang ho DBP le phokotso e tšoanang ho HR (ke hore baroreflex) ha e bapisoa le li-HC tse fetang 90 min post-dose. Li-PG li bonts'itse bofokoli ho cortisol ha bo bapisoa le li-HC tse ileng tsa khutlisoa ka tsela e itseng ke AMPH. Phokotso mosebetsing oa Stop Signal Task e hokahane hantle le HR maemong a taolo, empa hampe ka HR ho li-PG, e fana ka maikutlo a hore karabelo e matla le e qobelloang ea pelo ea motho ea matlafatsang e kanna ea bonts'a tšibollo ea pele. Teko e feteletseng e boletse esale pele ts'oaetso e kholo ho li-PG. Likhathatso tsa Noradrenergic li ka kenya letsoho ho arabelloeng ka maikutlo ho phephetso e matla le ts'oaetso ho li-PG.
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