Psychopharmacology (Berl). 2018 Jan; 235 (1): 23-35. doi: 10.1007 / s00213-017-4744-0. Epub 2017 Oct 30.
Di Ciano P1, Manvich DF2, Pushparaj A1, Gappasov A1, Hess EJ3, Weinshenker D2, Le Foll B4,5,6,7,8,9,10.
inahaneloang
RATIONALE:
Boloetse ba papali ea chelete ea papali ea chelete ke bothata bo ntseng bo eketseha sechabeng, joalo ka ha bo khetholloa ka karohano ea bona ea morao-rao e le bothata ba ho lemalla ho DSM-5. Litlaleho tsa nyeoe li bontšitse hore disulfiram e fokotsa boitšoaro bo amanang le papali ea chelete ho batho.
LIPOTSO:
Morero oa thuto ea hona joale e ne e le ho bona hore na discriram e ama ts'ebetso ea papali ea papali ea chelete, mofuta oa litheko tsa mosebetsi oa papali ea Iowa bathong, le hore na ho na le liphetoho tse amanang le liphetoho lipakeng tsa dopamine le / kapa norepinephrine.
LITLHAHISO:
Likhoto li ne li fanoa ka discriram pele ho liteko mosebetsing oa ho becha kapa pele ho tlhahlobo ea dopamine kapa norepinephrine maemong a boko. Likhoto tšebetsong ea boits'oaro li arotsoe ka likarolo tse peli (subimalt subptimal) ho latela maemo a bona a mantlha a ts'ebetso ea papali ea papali ea chelete. Likhoto sehlopheng se nepahetseng li khethile leano le leng ho feta, 'me likhoto sehlopheng se ikhethileng (e tsamaellanang le bothata ba papali ea chelete) li khethile leano le kotsi le ho feta. Likhoto li ne li sa arotsoe ka lihlopha tse phethahetseng kapa tse tlatsetsang pele ho tlhahlobo ea methapo ea kutlo.
LIKOTSO:
Disulfiram e tsamaisitse 2 h, empa eseng 30 min, pele ho ts'ebetso ea ts'ebetso ea litekanyetso e ntlafalitseng boits'oaro ba likhoto ka leano la pele le seng kotsi la "papali ea papali ea chelete", ha e na matla ho likhoto tse sebelisang leano le molemo. Litlamorao tsa boits'oaro ba disulfiram li ne li amahanngoa le ho eketseha ha striatal dopamine le ho fokotsa norepinephrine ea striatal.
CONCLUSIONS:
Liphumano tsena li fana ka maikutlo a hore liketso tse kopaneng ho dopamine le norepinephrine e ka ba kalafo e thusang bakeng sa mathata a papali ea chelete.
LINKOTSO: Antabuse; Dopamine; Ho becha; Norepinephrine
PMID: 29085979
PMCID: PMC5750121
DOI: 10.1007/s00213-017-4744-0
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