Mol Psychiatry. 2014 Dec; 19 (12): 1305-13. doi: 10.1038 / mp.2013.163. Epub 2013 Phato 10.
Boileau I1, Tefo D2, Chugani B3, Lobo DS4, Houle S5, Wilson AA5, Warsh J6, Kish SJ7, Zack M8.
inahaneloang
Ho lemalla lithethefatsi ho 'nile ha amahanngoa le likhaello mesebetsing ea mesostriatal dopamine (DA), empa ha ho tsejoe hore na naha ena e fetella litlamong tsa boitšoaro tse kang ho becha ha mafu (PG). Mona re ne re sebelisa positron emission tomography le radioligand e ratang ho amohela li-D3 [(11) C] - (+) - PHNO nakong ea protocol e habeli ea ho hlahloba ho lokolloa ha DA ho arabela amphetamine ea molomo ho batho ba papali ea chelete (n = 12) mme ba phetse hantle taolo (n = 11). Ho fapana le liphuputso tsa batho tsa ho lemalla lithethefatsi, re tlaleha bopaki ba pele ba hore PG e amahanngoa le tokollo e kholo ea DA ho dorsal striatum (54-63% e kholo [(11) C] - (+) - PHNO displacement) ho feta taolo. Habohlokoa, karabelo ea dopaminergic ho amphetamine ho bapapali ba papali ea chelete e ile ea boleloa esale pele ke maemo a li-receptor tsa D3 (a lekantsoeng ka substantia nigra), hape a amana le ho tiea ha papali ea chelete, ho lumella kaho ea mofuta oa mechini o ka thusang ho hlalosa menehelo ea DA ho PG. OLiphetho tsa ur li tsamaellana le boemo ba hyperdopaminergic ho PG, hape e tšehetsa khopolo-taba ea hore ts'ehetso ea dopaminergic e kenyelletsang mekhoa e amanang le D3 e ka kenya letsoho ho pathophysiology ea litloaelo tsa boitšoaro.
;