Bo-rasaense ba fokotsa boits'oaro bo amanang le bothata ba papali ea chelete literekeng
By Tsebiso ea boralitaba, | Science | 0 Comments
Ka thuso ea casino ea rat, bafuputsi ba kelello ba Univesithing ea Brithani ba atlehile ho fokotsa mekhoa ea litloaelo tse atisang ho amahanngoa le papali ea chelete e kenelletseng bathong.
Boithuto bona, bo bonts'itseng mokhoa oa pele oa katleho oa ho becha ka mokhoa oa slot mochine le litoeba Amerika Leboea, ke oa pele ho bonts'a mekhoa e metle ea ho becha e ka alafshoa ka lithethefatsi tse thibelang li-receptor tsa dopamine D4. Liphumano li phatlalalitsoe ka Likokoana-hloko tsa likokoana-hloko koranta.
"Ho hlokahala mosebetsi o mongata, empa liphumano tsena li fana ka tšepo e ncha bakeng sa kalafo ea ho lemalla papali ea chelete ea papali ea chelete, e leng ho ameha ka bophelo bo botle ba sechaba," ho bolela Paul Cocker, sengoli se etelletseng pele sa thuto le seithuti sa PhD ho UBC's Dept. of Psychology. "Phuputso ena e fana ka leseli le lecha la ts'ebetso ea boko e kenyelletsang papaling ea papali ea chelete le papali ea chelete."
Bakeng sa thuto, likhoto li ile tsa becha bakeng sa li-pellets tsa tsoekere tse sebelisang mochini o ikhethileng o nang le mabone a mararo a benyang le mekotla e 'meli eo ba ka e sutumetsang ka matsoho. Likhoto li bontšitse boits'oaro bo bongata bo amanang le ho becha ho mathata a kang tloaelo ea ho phekola "li-misses" tse ts'oanang le tsa win.
Ha a theha lipatlisiso tsa nakong e fetileng, sehlopha se ile sa tsepamisa maikutlo ho dopamine D4 receptor, e kopantsoeng le mathata a fapaneng a boitšoaro, empa ha ho mohla ho kileng ha ipaka e le thuso kalafong. Phuputso e fumane hore likhoto tse tšoaroang ka moriana o thibelang dopamine D4 li bonts'itse litekanyetso tsa boitšoaro bo amanang le ho becha ha bothata.
Ha liphuputso li fana ka maikutlo a hore ho thibela D4 dopamine receptor ho ka thusa ho fokotsa boits'oaro ba ho becha ba mmele ho batho, bafuputsi ba hlokometse hore lipatlisiso tse ling hape lia hlokahala pele lithethefatsi li ka nkuoa e le kalafo e sebetsang ea litlama bakeng sa ho becha ha methapo ho batho.
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"Ho becha ka tsela ea tlhaho ho ntse ho bonahala e le temallo ea boitšoaro e ts'oanang le bokhoba ba lithethefatsi kapa joala, empa ha re tsebe hore na u ka sebetsana joang le papali ea chelete." "Boithuto ba rona ke ba pele ba ho bonts'a hore ka ho thibela li-receptors tsena re ka khona ho fokotsa likarolo tse natefelo tsa liphoso tse haufinyane tse hlahang e le tsa bohlokoa papaling ea chelete."
Mekhoa: Thutong ea khoeli ea 16, sehlopha sa likhoto tsa laboratori tsa 32 li arabetse letoto la mabone a mararo a benyang pele a khetha pakeng tsa levers tse peli. Motsoako o mong oa mabone (mabone ohle a boneselitsoe) o ne o tšoaea win mme o kopanya tse supileng (zero, lebone le le leng kapa tse peli) tse tšoaeang tahlehelo. Motho ea neng a “tsoa chelete” o ile a putsa mopalami ka li-pellets tsa tsoekere tsa 10 litekong tsa ho hapa, empa a fana ka kotlo ea "nako ea" 10-ea bobeli ea ho lahleheloa ke litselana. Lever ea "roll hape" e lumelletse likhoto hore li qale nyeoe e ncha ntle le kotlo, empa ha li ba felle ka tsoekere.
Ho khahlisang, likhoto li bonts'itse mokhoa oa ho khetha mokoloto o tsoang chelete ha mabone a mabeli (a haufi-leseling) a bonesa, a fana ka maikutlo a hore likhoto, joalo ka batho, li kotsing ea ts'ebetso e haufi. Ka ho thibela li-receptor tsa D4 ka lithethefatsi, bafuputsi ba atlehile ho fokotsa khetho ea rat ea motho ea "felisang chelete" litekong tse sa hapeng.
Moriana oa blocker oa D4 o sebelisitsoeng thutong o kile oa lekoa ho batho ho leka ho phekola mathata a boitšoaro joaloka schizophrenia empa a bonahala a sena phello.
Metsotso e haufi: Leeme lena le totobetseng le bonoa le nkoa e le karolo ea bohlokoa ntlafatsong ea mathata a ts'ebeliso ea ho becha. Taba ea hore metjeko ea li-slot e tloaetse ho ba le palo e phahameng haholo ea lintho tse haelloang haholo ha li bapisoa le lipapali tse ling tsa papali ea chelete e ka ba lebaka la hore metjeko ea li-slot ke mofuta o joalo oa papali ea chelete.
Bangoli ba thuto: Paul Cocker le Prof. Catharine Winstanley (UBC Dept. of Psychology), Bernard Le Foll (Univesithi ea Toronto, Setsi sa Tlatsetso le Bophelo ba Kelello) le Robert D. Rogers (Univesithi ea Bangor). Boithuto, Karolo e Khethehileng ea Dopamine D4 Receptors ho Modulating Rewardancy in a Rodent Slot Machine Task e fumaneha ha ho kopitsoa.
Laborator ea UBC ea Metlale le Behaeveal Neuroscience, e etelletsoeng pele ke Psychology Prof. Catharine Winstanley, e tsepamisa maikutlo ho utloisisa mekhoa ea bioloji ea mesebetsi e kang taolo ea tšusumetso le papali ea chelete, e lebisang ho liphekolo tse ncha le tse ntlafalitsoeng bakeng sa mathata a kang khaello ea hloko ea methapo ea kutlo, pherekano ea kelello, mathata a botho , le bokhoba ba lithethefatsi.
Bothata ba papali ea chelete: Ho becha ho tlamang ho ama liperesente tse tharo ho isa ho tse hlano tsa Maamerika a Amerika Leboea, ho latela lipalo tsa morao tjena.
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