Front Behav Neurosci. 2013; 7: 147.
Mehopolo e bapala karolo ea bohlokoa boits'ebetsong bo lematsang. Sena se kanna sa etsahala haholo ho "bokhoba ba boitšoaro," joalo ka papali ea chelete ea methapo, moo matlafatso a tsoang liketsahalong tsa tikoloho tseo boleng ba tsona bo ithutileng haholo. Boithuto bo entsoeng ke Porchet le basebetsi mmoho le bona bo hlahloba likarolo tsa dopamine le li-opioid tsa mehleng ea khale ho arabela mesebetsi e reretsoeng ho tsosa maikutlo a amanang le papali ea chelete papaling ea papali ea chelete.
Bafuputsi ba tlaleha hore dopamine D2 receptor antagonist, haloperidol e bile le phello e fokolang ho likarabo tsa subjential mabapi le liphoso tse haufi (liphetho tse lekanang hantle le katleho ea) empa li ntlafalitse hanyane boitlhakiso ba 'mele boitekong bona.
Ka lehlakoreng le leng, motsoako oa opioid receptor antagonist, naltrexone o ile a eketsa ts'ebetso ea 'mele ho lintho tsena hape a eketsa le kholiseho ea boikemisetso ba ho bolela esale pele liphetho tsa kamoso ho latela mosebetsi o moholo oa ho hapa.
Se fumanoeng bakeng sa haloperidol se lumellana le karabelo e eketsehang ea 'mele le ho se be le litlamorao tsa setlhare sena ka lebaka la ts'ebetso ea papali ea chelete e neng e kile ea bonoa ho batho ba phetseng hantle.
Liphumano tsa naltrexone ha li etse lintho ka morero, hobane naltrexone le mohanyetsi oa opioid nalmefene li ipakile li sebetsa ho thibela takatso ea ho becha. Le ha ho sa boleloa ka botlalo, liphetho li tiisa hore, joalo ka lithethefatsi tsa tlhekefetso, ts'ebetso ea papali ea chelete ea ts'ebeliso ea ts'ebeliso ea ts'ebetso ea ts'ebetso ea ts'ebetso ea ts'ebetso ea ts'ebetso ea ts'ebeliso ea marang-rang e ts'epahetse. Hammoho le bopaki bo bong, ba boetse ba fana ka tlhahiso ea hore basomi ba boithabiso ba ka arabela ka tsela e fapaneng litšebelisong tsa lithethefatsi ho fapana le ho becha ka lebaka la karohano e sebetsang bokong ba batho bana ba babeli.
Le ha litlamorao e le tsa boithabiso gababolai ba bonts'a pherekano e tsoang ho ts'ebetso ea mantlha ea homeostatic, keketseho ea lisele tse dopamine e qaptjoang ke haloperidol le keketseho ea axis e arabang e hlahisoang ke naltrexone e ka nka bohato ba ho khutlisa kapa ho fokotsa ho kheloha hoa ts'ebetso e tloaelehileng ea boko e emelang motheo o mocha oa "brain" kapa "allostatic" boemo ba boko ba motho ea bechang. Ho pheta-pheta teko ena ho batho ba betšang ba pathological e ka ba tlatsetso ea bohlokoa thutong ena ea bohlokoa.
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