Papali ea papali ea chelete ea ho becha le ho reka ho qobella: na ba oela ka har'a mefuta e mengata ea ho qobella batho ba bang? (2010)

Dialogues Clin Neurosci. 2010;12(2):175-85.

Donald W. Ntsho, MD*

Donald W. Black, Lefapha la Psychiatry, Univesithi ea Iowa Roy J. le Lucille A. Carver College of Medicine, Iowa City, Iowa, USA;

Martha Shaw, BA

Martha Shaw, Lefapha la Psychiatry, Univesithi ea Iowa Roy J. le Lucille A. Carver College of Medicine, Iowa City, Iowa, USA;

Eya ho:

inahaneloang

Ka bobeli ho rekisoa ka mokhoa o qobelloang (CB) le ho tsubella ha methapo ea methapo (PG) e se e le litho tsa koluoa ​​ea pono e amanang le mathata a amanang le botšosi (OCD). Hypothesis ea spectrum e simolohile ho li-1990 tsa pele mme e fumane tšehetso e kholo, leha ho sa na bopaki bo matla. Ho khahloa ke khopolo ena ho fetohile taba e nyarosang hobane bafuputsi ba bang ba khothalelitse ho etsoa ha sehlopha se secha se kenyeletsang mathata ana ho DSM-5, eo hona joale e ntseng e tsoela pele. Sengoliloeng sena, bangoli ba hlalosa tšimoloho ea pono ea boiketsetso (OC) le litekanyetso tsa eona tsa theoretical, ba hlahlobe bobeli ba CB le PG, 'me ba buisane ka tlhaiso-leseling ka ts'ehetso le khahlanong le pono ea OC. Mathata ana ka bobeli a hlalosoa ho latela nalane ea ona, tlhaloso, karohano, phenomenology, nalane ea lelapa, pathophysiology, le taolo ea bongaka. Bangoli ba phethela ka hore: (i) CB le PG mohlomong ha li na kamano le OCD, mme ho na le bopaki bo sa lekanang ba ho li beha ka har'a ponahalo ea OC ho DSM-V; (ii) PG e tlameha ho lula le mathata a taolo ea tšusumetso (ICDs); le (iii) tlhahlobo e ncha ea lefu la CB e lokela ho thehoa le ho khethoa e le ICD.

Keywords: ho reka ka mokhoa o phehellang, papali ea chelete ea methapo ea mali, papali ea pono e bonoang, tšusumetso ea taolo ea tšusumetso, ho lemalla boitšoaro

Li-1990 tsa pele, thahasello e ile ea qala ho hola ho pota mohopolo oa ponelopele e bonts'ang (OC). Hollander le ba bang1-3 o ngotse ka letoto la mafu a amanang le ho senyeha hoa kelello (OCD). Ho ipapisitse le boiphihlelo ba hae joalo ka mofuputsi oa OCD, Hollander o ile a nka OCD e le setsi sa pono, mme a hlalosa botebo ba eona le ho feta ka mathata a mang a mangata a kelello. Mathata ana a ne a nkuoa e le 'mela oa orthogonal oa ho qobella ho qobelloa, ho se ts'oenyehe vs. netefatso, le cognitive vs motoric (likarolo). Mohopolo oa ponts'o ea OC o ile oa amoheloa kapele ke bafuputsi ba bang hobane o ile a fana ka tsela e ncha ea ho nahana ka kamano pakeng tsa mathata a mangata a lahliloeng, mme a fana ka likhetho tse ncha tsa kalafo.4,5 Ha se lipatlisiso tsohle tse lumellaneng, 'me ho hlahile tlhahlobo e' maloa e thata.6-9

Leha ho na le tlhahlobo, mohopolo oa sehlopha sa mathata a amanang le OCD o ntse o le ngata haholo. Mohopolo oa hore likhathatso li amana le merero ea bohlophisi, ke hobaneng ha sehlopha sa mathata eseng amanang le OCD? Potso ena joale e khahlisa haholo hobane ba ikarabellang bakeng sa ho hlahisa khatiso ea bohlano ea Buka ea ho hlahloba le ea Statistical of Disabilities (DSM-5) e tlameha ho nka qeto ea hore na e etsa sehlopha se arohaneng sa OCD le mathata a amanang le eona, kapa ho boloka OCD e na le mathata a ho tšoenyeha. Haeba ba theha sehlopha se secha sa pono ea OC ba tla hloka ho tseba bophara ba eona.

Meeli ea maqhubu a OC e atolohile kapa e entsoe tumellano ho latela maikutlo a mofuputsi ea amehang. E 'nile ea hlalosoa e le ho kenyelletsa mathata a taolo ea tšusumetso e joalo ka papali ea papali ea chelete (PG), trichotillomania le kleptomania; Mathata a Tourette le a mang a tic; mathata a botho a sa tsitsang (mohlala, bothata ba botho bo moeling); hypochondriasis le boloetse ba "dysmorphic body"; mathata a ho ja; le mathata a 'maloa a sa tsejoeng hajoale ho DSM-IV-TR 10 joalo ka ho reka ka mokhoa o qobelloang (CB) le tlhekefetso ea thobalano.1-4 Bafuputsi ba fokolang ba fokolang ba faneng ka bopaki ba ho tiisa kamano lipakeng tsa mafu ana. Ka tloaelo, bopaki bo joalo bo ka kenyelletsa papiso ea phenomenology, nalane ea tlhaho, nalane ea lelapa, matšoao a tlhaho le karabelo ea kalafo.11

OCD e na le sebaka sa bohlokoa bohareng ba setsi. Hajoale e kengoe kahare DSM-IV-TR 10 ha e le bothata ba ho tšoenyeha, OCD e ikemetse khahlanong le mathata a mang a ho tšoenyeha tsamaisong ea Machaba ea Ts'oants'o ea Mafu (ICD),12 mme maikutlo a matla a hlahisitsoe ke Zohar et al13 bakeng sa ho ikarohana ha eona le mafu ana. Taba ea mantlha, OCD hangata e qala bongoaneng, athe hangata mathata a mang a ho tšoenyeha a na le lilemo tse tlang tsa ho qala. OCD e na le phano ea tekano ea bong e batlang e lekana, ho fapana le mathata a mang a ho tšoenyeha, a atileng haholo ho basali. Boithuto ba bongaka ba kelello ba kelello bo bonts'a hore, ho fapana le mathata a mang a ho tšoenyeha, batho ba nang le OCD ka kakaretso ha ba na litheko tse phahameng tsa tšebeliso e mpe ea lithethefatsi. Lithuto tsa lelapa ha li a bonts'a kamano e hlakileng pakeng tsa OCD le mathata a mang a ho tšoenyeha. Li-circry tsa boko tse sebelisang 'mele oa OCD ho bonahala li fapane le se amehang matsatsing a mang a ho tšoenyeha. Qetellong, OCD e ikhethile mabapi le karabelo ea eona ho li-serotonin reuptake inhibitors (SSRIs), leha meriana ea noradrenergic, e sebetsang maemong a ho feto-fetoha ha maikutlo le ts'ebeliso e itseng ea mathata a ho tšoenyeha, ha e na thuso ho OCD. Ka lehlakoreng le leng, li-benzodiazepines, tse nang le phello e fokolang ho OCD, hangata li sebetsa bakeng sa mathata a mang a ho tšoenyeha. Ho ea pele, Zohar et al13 ba boletse hore ho lemoha sebono ho ka tlatsetsa ho ntlafatseng tatellano, ka hona ho nolofaletsa litlhaloso tse hlakileng haholoanyane tsa endophenotype le matšoao a biological a tšoaeang maemo ana, le hore khethollo e betere e ka lebisa ho kalafo tse ikhethang.

Karolo e tsoang ho monyetla oa ponts'eho ea OC, ha ho mokhoa o ts'oanang oa ho beha likarolo tsa khatello le tse qobelloang. Ha ba bang ba nyelisitse "bongaka" boits'oaro bo nang le mathata bo kang CB,14 Puisano e shebile haholo hore na mathata ana a lokela ho khetholloa joang, likamano tsa bona le mathata a mang a bonts'a maikutlo a OC, le hore na ba bang ba eme ba le bang e le likhathatso tse ikemetseng (mohlala, boitšoaro ba boits'oaro bo matla ba thobalano).

Merero e meng ea khethollo e totobalitse kamano ea bothata bo sa bonahaleng ba OC ho tepella maikutlo kapa mathata a mang a ho feto-fetoha ha maikutlo, ho mathata a taolo ea tšusumetso (ICDs) kapa mathata a lemalloang. Haufinyane, ho fanoe ka maikutlo a hore bonyane mafu a mang a kenyellelitsoeng sebopeho sa OC a kenngoe kahare ho sehlopha se secha sa tlhahlobo se kopantseng tlhekefetso ea boitšoaro le lithethefatsi.15 "Ho ba le boitšoaro" ho kenyelletsa mathata a Setsi sa Naha sa Ts'ebeliso ea Lithethefatsi (NIDA) a nkang e le mehlala e metle ea ho lemalla hobane ha e silafatsoe ke ho ba teng ha ntho ea khale.

Ka nalane ena kelellong, sengoloa sena se tla bua ka boemo ba PG le CB. Na mathata aa ke karolo ea sebopeho sa OC joalo ka ha ho hlalositsoe ke Hollander le basebetsi-mmoho? Na li nkuoa ka tsela e loketseng li nkuoa li le mathata a taolo ea tšusumetso kapa li lemallo? Na li amana? Lipotso tsena le tse ling li tla hlahlojoa ha re ntse re hlahloba sepheo sa CB, PG le pono ea OC.

Ho reka ka mokhoa o qobelloang

CB e hlalositsoe ka har'a nomenclature ea mafu a kelello bakeng sa lilemo tse ka bang 100. Ngaka ea mafu a kelello ea Jeremane Emil Kraepelin16 o ngotse ka mabenkele a sa laoleheng le mokhoa oa ho senya chelete o bitsoang oniomania ("Ho reka mania"). Hamorao o ile a qotsoa ke setsebi sa kelello sa Switzerland sa Eugen Bleuler17 ho eena Lehrbuch der Psychiatrie:

E le mokhahlelo oa hoqetela, Kraepelin o bua ka maniacs ea ho reka (oniomaniacs) eo ho reka le hona ho qobelloang mme ho lebisang ho khutsufatso e se nang kelello ea mekoloto ka ho lieha ho patala ha tefo ho fihlela koluoa ​​e hlakola boemo hanyane - hanyane ha ho mohla ba bang hobane ha ba lumele tsohle melato ea bona. …. Karolo e ikhethang ke ho potlaka; ba sitoa ho e thusa, eo ka linako tse ling e bileng e itlhalosang ka hore ba sa mamelle bohlale bo botle ba sekolo, bakuli ha ba khone ho nahana ka tsela e fapaneng le ho nahana ka litlamorao tsa ketso ea bona, le menyetla ea ho se e etse. ” (p 540).

Kraepelin le Bleuler e mong le e mong o ile a nka ho “reka mania” e le mohlala oa a tšusumetso e sebetsang or bohlanya bo sa susumetseng, 'me a e beha haufi le kleptomania le pyromania. Mohlomong ba ile ba susumetsoa ke ngaka ea mafu a kelello ea Mofora, Jean Esquirol18 mohopolo oa pejana oa monomania, polelo eo a neng a e sebelisa ho hlalosa batho ba tloaelehileng ba neng ba e-na le mokhoa o mong oa ho iphatlalatsa ka lefu la kelello.

CB e hohela tlhokomelo e nyane ho fihlela li-1980 tsa morao le li-1990 tsa pele ha bafuputsi ba boitšoaro ba bareki ba bonts'a moferefere ona hohle19-21 mme lithuto tse hlalosang li ile tsa hlaha ka har'a lingoliloeng tsa mafu a kelello.22-25 McElroy et al22 e hlahisitse tlhaloso ea ts'ebetso e kenyelletsang boits'oaro le boits'oaro ba CB. Tlhaloso ea bona e hloka bopaki ba bofokoli bo bakoang ke khatello ea maikutlo e ikhethileng, ho kena-kenana le tšebetso ea sechaba kapa ea mosebetsi, kapa mathata a lichelete / molao. Ho feta moo, lefu lena le ne le ke ke la bakoa ke mania kapa hypomania. Litlhaloso tse ling li tsoa ho bafuputsi ba boits'oaro ba bareki kapa litsebi tsa kelello tsa kahisano. Faber le O'Guinn26 e hlalositse pherekano ena e le "likarolo tse sa reroang tsa ho reka tse sa tloaelehang moo moreki a utloang a sitoa ho emisa kapa ho etsa boits'oaro bo botle haholo" (p 738). Motšehare,27 setsebi se seng sa boits'oaro ba bareki, se fana ka maikutlo a hore ho reka ka qobello ke "mokhoa o sa tloaelehang oa ho reka le tšebeliso ea chelete moo moreki ea nang le khatello a nang le takatso e matla e sa laoleheng, e sa foleng le e pheta-phetang ea ho reka le ho sebelisa (e sebetsang)… e le mokhoa oa ho fokotsa maikutlo a mabe a khatello ea maikutlo ho tšoenyeha. ” (leqephe 67) Dittmar28 e hlalosa likarolo tse tharo tsa bohlokoa: tšusumetso e ke keng ea thijoa, tahlehelo ea taolo, le ho tswela pele ho sa na le litlamorao tse bohloko. Bafuputsi ba bang ba boits'oaro ba bareki ba nka karolo ea CB e le karolo ea boits'oaro bo bobe ba bareki, bo kenyelletsang papali ea chelete ea kelello, ho utsoa mabenkeleng le tlhekefetso ea mokoloto.29

CB ha e kenyelelitsoe ho DSM-IV-TR10 kapa Mokhatlo oa Lefatše oa Bophelo Tlhophiso ea Machaba ea Maloetse, Khatiso ea Leshome.12 Hore na o ka kenyelletsa CB ho DSM-5 e ntse e ngangisana.30 McElroy et al23 fana ka maikutlo a hore boitšoaro bo qobelloang ho ea mabenkeleng bo ka amana le "mathata a laoloang ke maikutlo kapa khatello ea taolo kapa ea tšusumetso." Lejoyeux et al31 ba e hokahanya le mathata a maikutlo. Ba bang ba nka hore CB e amana le mathata a tšebeliso ea lithethefatsi.32,33 Ba bang ba fana ka maikutlo a ho khetholla CB e le bothata ba taolo ea tšusumetso34 kapa bokuli ba maikutlo.35

Faber le O'Guinn26 e hakanyetsa ho ata ha CB lipakeng tsa 1.8% le 8.1% ea sechaba ka kakaretso, ho ipapisitse le liphetho tse tsoang ho patlisiso ea mangolo moo Compulsive Buying Scale (CBS) e ileng ea tsamaisoa ho batho ba 292 ba khethiloeng ho hakanyetsa sebopeho sa palo ea baahi ka kakaretso ba Illinois . (Tekanyetso e phahameng le e tlase ea tšoaetso e bonts'a likotsi tse fapaneng tsa likheo tsa CB.) Haufinyane tjena, Koran et al36 e sebelisitse CBS ho khetholla bareki ba qobelloang tlhahlobong ea mohala e sa sebetseng ea batho ba baholo ba 2513 US, mme a hakanya ho ata ha ntlha ho 5.8% ea ba arabelitsoeng. Grant et al37 o sebelisitse MIDI ho lekola CBD mme a tlaleha ho ata ha bophelo ba 9.3% har'a 204 ka ho latellana e anngoeng ke lingaka tsa mafu a kelello.

CB e na le qaleho ea ho ba lilemong tsa bocha tsa 20s kapa ho feta, tse ka lumellanang le tokollo ho tsoa lelapeng la nyutlelie, hammoho le lilemo tseo batho ba ka qalisang mokoloto ho tsona pele.34 Patlisiso e fana ka maikutlo a hore 80% ho 94% ea batho ba nang le CBD ke basali.38 Ka lehlakoreng le leng, Koran et al36 tlaleha hore ho ata ha CBD tlhahlobong ea bona ea mohala e sa sebetseng e batla e lekana le ea banna le basali (5.5% le 6.0%, ka ho latellana). Seo ba se fumaneng se fana ka maikutlo a hore phapang e tlalehiloeng ea bong e ka ba ntho ea khale, ka hore basali ba amohela habonolo mokhoa o sa tloaelehang oa ho reka ho feta banna. Banna ba na le monyetla oa ho hlalosa ho reka ha bona ka thata e le ho “bokella.”

Lintlha tse tsoang liphuputsong tsa bongaka li netefatsa litheko tse phahameng tsa khatello ea kelello, haholo molemong (21% ho 100%), matšoenyeho (41% ho 80%), ts'ebeliso ea lithethefatsi (21% ho 46%), le mathata a ho ja (8% ho 35 %).38 Mathata a taolo ea litšusumetso a boetse a tloaelehile (21% ho 40%). Khafetsa ea mathata a Axis II ho batho ba nang le CB e ile ea hlahlojoa ke Schlosser et al25 o sebelisa sesebelisoa sa boiketsetso le puisano e hlophisitsoeng. Hoo e batlang e le 60% ea lithuto tsa 46 e ile ea kopana le maemo a bonyane tlokotsi ea botho bo le bong ka tumellano ea liletsa ka bobeli. Mathata a tsebahalang ka ho fetesisa a botho e ne e le mefuta e feteletseng (22%), e ka thibelang (15%), le mefuta ea moeli (15%).

Setšoantšo sa kliniki se ikhethileng le se sothehileng sa mohoebi ea qobelloang se hlahile. Ntsho39 o hlalositse mekhahlelo e mene e kenyeletsang: (i) tebello; (ii) litokisetso; (iii) mabenkele; le (iv) tšebeliso. Karolong ea pele, motho ea nang le CB o lula a amehile ka ho ba le ntho e itseng, kapa ka ketso ea ho ea mabenkeleng. Sena se lateloa ke karolo ea boitokiso eo ho eona merero e entsoeng. Mohato ona o lateloa ke boiphihlelo ba nnete ba ho reka, boo batho ba bangata ba nang le CB ba bo hlalosang e le bo thabisang haholo.25 Ketso e phetheloa ka ho reka, hangata ho lateloa ke maikutlo a ho nyahama kapa ho nyahama.36

Mohlomong ntho e tsebahalang ka ho fetisisa ke hore ke ho nahanisisa ka ho reka le ho sebelisa chelete. Hangata sena se etsa hore motho a qete lihora tse ngata beke le beke a etsa lintho tsena.24,25 Batho ba nang le CB khafetsa ba hlalosa tsitsipano kapa matšoenyeho a ntseng a eketseha ha ho rekoa. Boitšoaro ba CB bo etsahala selemo sohle, empa bo ka ba thata le ho feta nakong ea Keresemese le matsatsi a phomolo a mang, hammoho le ho potoloha matsatsi a tsoalo a litho tsa lelapa le metsoalle. Bareki ba qobelloang ba thahasella haholo thepa ea bareki e kang liaparo, lieta, mesebetsi ea matsoho, mabenyane, limpho, litlolo le li-compact disc (kapa li-DVD)24,25 CB ha e amane le maemo a kelello kapa a thuto, 'me e ngotsoe ho batho ba hlaphohetsoeng kelellong.40 Ka mokhoa o ts'oanang, chelete e kenang ha e na taba le CB, hobane batho ba nang le moputso o tlase ba ka tšoareha haholo ka ho reka le ho sebelisa chelete joalo ka batho ba ruileng.38,40

Nataraajan le Goff42 e thathamisitse lintlha tse peli tse ikemetseng ho CB: (i) takatso ea ho reka kapa takatso, le (ii) tekanyo ea taolo ea ho reka. Ka mofuta oa bona, bareki ba qobelloang ba kopanya takatso e phahameng le taolo e tlase. Pono ena e lumellana le litlaleho tsa tliliniki tsa hore bareki ba qobelloang ba tšoarehile ka ho reka le ho sebelisa chelete mme ba tla leka ho hanela litakatso tsa bona, hangata ka katleho e nyane.24,38

Boithuto bo mabapi le likarolo tse ling bo fana ka maikutlo a hore lefu lena ha le fole, leha le ntse le fetoha ka botebo le matla.22,25 Aboujaoude et al43 a tlaleha hore batho ba arabileng kalafo ka citalopram ba kanna ba lula ba tšoarelle nakong ea tlhahlobo ea 1 ea lilemo tse ngata, a fana ka maikutlo a hore kalafo e ka fetola nalane ea tlhaho ea lefu lena. Lejoyeux et al44 tlaleha hore CB e amahanngoa le liteko tsa ho ipolaea, leha ho se na litlaleho tsa lefu lena le lebisang ho ipolaeeng ho phethehileng.

Ho na le bopaki bo bong ba hore CB e sebetsa malapeng le hore malapeng ana maikutlo, ho tšoenyeha le mathata a tšebeliso ea lithethefatsi a feta palo ea baahi. Fekete et al45 o sebelisitse mokhoa oa nalane ea lelapa ho lekola beng ka 137 ba mathomo ba batho ba 31 ba nang le CB. Beng ka bona ba ne ba na le menyetla e mengata ho feta ea hore sehlopha se bapisoe le khatello ea maikutlo, bokhoba ba tahi, bothata ba tšebeliso ea lithethefatsi, "khatello ea kelello" le "mafu a kelello a fetang a le mong." CB e fumanoe hoo e batlang e le 10% ea baena ba pele. empa ha e ea hlahlojoa sehlopheng sa papiso.

Likhopolo tsa Neurobiologic li tsepamisitse maikutlo ho ts'ebetso ea methapo e ferekanyang, haholo-holo e kenyelletsa lits'ebetso tsa serotonergic, dopaminergic kapa opioid. Li-serotonin reuptake inhibitors tse khethiloeng li sebelisitsoe ho phekola CB,46-50 karolo e le 'ngoe ka lebaka la ho ts'oana ha hypothetical pakeng tsa CB le OCD, bokuli bo tsejoang ho arabela ho li-SSRIs. Dopamine e hlahisitsoe hore e bapala karolo ea "ho itšetleha ka moputso," eo ho thoeng e khothaletsa bokhoba ba boitšoaro, bo kang CB le PG15 Litlaleho tse fanang ka maikutlo a ho rua molemo ho optiox antagonist naltrexone li lebisitse ho khopolong mabapi le karolo ea li-receptor tsa opioid51 Ha ho na bopaki bo tobileng, leha ho le joalo, ba ho tšehetsa karolo ea li-system tsena tsa neurotransmitter ho etiology ea CB.

Hobane CB e etsahala haholo linaheng tse tsoetseng pele, ho hlahisitsoe mabaka a setso le a sechaba e le a ka bakang kapa a phahamisa moferefere.39 Ho khahlisang, Neuner et al52 e tlaleha hore khafetsa ea CB Jeremane e eketsehile kamora ho kopana hape, e fana ka maikutlo a hore lintlha tsa sechaba li ka kenya letsoho kholisong ea CB. Tsena li ka kenyelletsa ho ba teng ha moruo o rekisoang 'marakeng, thepa fumaneha, mokitlane o fumanehang habonolo, le chelete e lahlehang.14

Ha ho na liphekolo tse tloaelehileng, 'me ho khothalelitsoe kalafo ea kelello le meriana. Lipatlisiso tse 'maloa tsa linyeoe li tlaleha kalafo ea psychoanalytic ea CB.53-55 Haufinyane tjena, ho entsoe mefuta ea kalafo ea kalafo ("CT)" bakeng sa CB, bongata ba bona ba sebelisa kalafo ea sehlopha56,57 Mitchell et al57 e fumane hore sehlopha sa CBT se hlahisitse ntlafatso ea bohlokoa ha se bapisoa le lenane la ho leta thutong ea sefofane ea 12-beke. Ntlafatso e hlahisitsoeng ke CBT e bolokiloe nakong ea tlhahlobo ea khoeli ea 6. Benson58 e hlahisitse lenaneo le akaretsang la ho ithusa le ka sebelisoang ke batho ka bomong le lihlopha.

Lithuto tsa kalafo tse sebelisang meriana ea psychotropic li hlahisitse liphetho tse fapaneng. Litlaleho tsa pejana li khothalelitse melemo ea li-antidepressants tsa ho alafa CB22,23 Fekete et al46 e tlaleha sephetho sa teko ea mabitso e bulehileng eo lithuto tse fuoeng fluvoxamine li ileng tsa bontša molemo. Liteko tse peli tse ileng tsa latela tse laoloang ka tšohanyetso (RCTs) tse ileng tsa latela ka lekunutu li fumane kalafo ea fluvoxamine e se betere ho feta placebo.47,48 Koran et al51 hamorao e tlaleha hore lithuto tse nang le CB li ntlafalitsoe ka "citalopram" e bulehileng. Phuputsong e ileng ea latela, lithuto li fumane li-citalopram tse bulehileng; ba neng ba nkuoa e le ba arabelang ba ne ba hlophisitsoe ka mokhoa o sa tloaelehang ho citalopram kapa placebo. Matšoao a qobelloang a ho reka a khutlisetsoe ka lithuto tsa 5 / 8 (62.5%) tse fuoeng placebo ha li bapisoa le 0 / 7 ea ileng a tsoela pele ho nka citalopram. Ka teko e entsoeng ka mokhoa o tšoanang oa discontinuation, escitalopram ha ea ka ea arohana le placebo.52 Hobane liphuputso tse fumanoeng lithupelong tsa bongaka li tsoakiloe, ha ho litlhahiso tse fanoang ka tšehetso e fanoang ka tšusumetso e matla hantle tse ka etsoang. Liteko tsa Openlabel ka kakaretso li hlahisitse litholoana tse ntle, empa li-RCT ha li so etse. Tlhaloso ea liphetho tsena tsa boithuto e thatafatsoa ke litekanyetso tsa karabelo ea placebo tse phahameng joalo ka 64%.47

Papali ea papali ea chelete

PG e ntse e hlokomeleha le ho feta e le bothata bo boholo ba bophelo bo botle ba sechaba.59 PG e hakanyetsoa ho lefella sechaba hoo e batlang e le limilione tse likete tsa 5 ka selemo le sekhahla sa 40 se eketsehileng bakeng sa litšenyehelo tsa bophelo bo fokotsehileng bakeng sa tlhahiso e fokotsehileng, lits'ebeletso tsa sechaba, le tahlehelo ea mokoloto. Bothata bona bo senya boleng ba bophelo ho feta kopanong ea bona le mathata a kelello a kelello, ho senyeha ha kelello le kelello. le ho ipolaea.59-61 Mathata a amanang le lelapa a kenyelletsa khatello ea lichelete, tlhekefetso ea bana le balekane, tlhalo le karohano.61

Le ha mekhoa ea mathata a ho becha e 'nile ea amoheloa ka makholo a lilemo, hangata e ne e hlokomolohuoa ke sechaba sa kelello. Bleuler,17 Cra Kraepelin,16 nkoa PG, kapa "mania a ho becha," a tšusumetso e khethehileng ho hloka kelello. Litekanyetso tsa PG li qalisitsoe ka lekhetlo la pele ho 1980 ho DSM-III. 62 Litekanyetso li ile tsa fetoloa kamora moo, 'me ka DSM-IV-TR, 10 li etsisoa kamora tse sebelisetsoang ho itšetleha ka lithethefatsi 'me li totobatsa likarolo tsa mamello le ho hula. PG e hlalosoa e le "boits'oaro bo phehellang le bo iphetang ba boitšoaro bo bobe ba papali ea chelete (moelelo oa A) o sitisang lithahasello tsa motho ka mong, tsa lelapa kapa tsa mosebetsi oa matsoho…" Ho thathamisitsoe boits'oaro bo itseng ba maladaptive, 'me> 5 e ea hlokahala bakeng sa tlhahlobo. Mekhoa e shebile tahlehelo ea taolo ea boits'oaro ba papali ea chelete; ho senyeha ho tsoelang pele ha lefu lena; le ho tsoela pele ho sa natsoe litlamorao tse mpe. Ho fumanoa ho ka etsoa feela ha mania e sa nkuoe (Criterion B). Ka boiteko ba ho lumellanya mekhoa ea mabitso le mekhoa ea ho lekanya, Shaffer le Hall63 o thehile moralo oa tlhahlobo ea generic multilevel eo hona joale e amoheloang haholo ke bafuputsi ba papali ea chelete.

Hona joale PG e khethiloe e le bothata ba taolo ea tšusumetso ho DSM-IV-TR. 10 Ka lehlakoreng le leng, bafuputsi ba bang ba boletse hore PG e amana le OCD,1,64 empa ba bang bona ba hanyetsa kamano e joalo.65 Ka lehlakoreng le leng, PG e nkuoa hohle e le lefu le lematsang.66,67 Haufinyane ho hlahisitsoe qeto ea ho ba mokhethoa oa ho kenyelletsoa sehlopheng se secha sa "bokhoba ba boitšoaro." 15 Likhakanyo tsa morao-rao tsa bophelo bo atileng bakeng sa mefuta ea PG ho tloha 1.2% ho 3.4% ho bongata ka kakaretso.68,69 Sekhahla sa tikoloho se nyolohile libakeng tseo ho fumaneha papali ea chelete ho tsona.70.71 Tlhahlobo ea naha e bonts'itse hore ho fumaneha ha casino ka har'a maili a 50 ho amana le keketseho e atileng habeli ea ho ata ha PG.59 Tloaelo ea papali ea chelete ea ho becha e qala bongoaneng, ha PG e nts'etsopele ke li-20 tsa morao kapa 30 ea pele,72 leha e ka qala ka nako efe kapa efe ka senescence. Litefiso tsa PG li phahame haholo ho banna, empa lekhalo la bong e ka 'na ea fokotseha.PG e qala ho ba le basali hamorao empa e tsoela pele ka lebelo le fetisisang ("telescoping") ho feta ho banna,73 ka tekanyo e ts'oanang le e bonoang mathateng a joala. Baahi ba kotsing ba kenyelletsa batho ba baholo ba nang le bophelo bo botle ba kelello kapa ba ts'ebeliso e mpe ea lithethefatsi, batho ba kentsoeng chankaneng, Ma-Amerika-Maamerika le batho ba maemo a tlase sechabeng.74,75

Patlisiso ha e so netetse li-subtypes tsa PG, empa mohlomong phapang e atileng ho hlalosoa ke pakeng tsa "batho ba balehelang" le "ba batlang maikutlo a boithati." 76 Batho ba batlang ho baleha hangata ke batho ba baholo ba jang papali ea chelete, ba tepeletseng maikutlo kapa ba tlalang nako, 'me ba khetha mefuta ea papali ea chelete e kang metjeko e mebetsang. Batho ba batlang litlolo ba tloaetse ho ba banyane lilemong, 'me ba khetha ho nyakalla ha lipapali tsa likarete kapa lipapali tsa tafole tse kenyelletsang karolo e sebetsang.76 Blaszczynski le Nower77 ba hlahisitse mofuta oa "tsela" o kopanyang likokoana-hloko, nts'etsopele, kutloisiso, le lintlha tse ling tsa papali ea chelete e se nang mabaka. Ba thathamisitse litlatse tse tharo tse tlase: a) baetsi ba maemo a bophelo bo botle; b) Bacha ba kotsing ea ho tsuba; le c) ba bechang, ba sa tsubeng. Batho ba tloaetseng ho becha ha ba na mokhoa o ikhethang oa ho hlasela kelello empa ba fana ka likahlolo tse fosahetseng mabapi le papali ea chelete. Bacha ba kotsing ea ho becha ba tepella maikutlo kapa ba tšoenyehile, ebile ba na le nalane ea ho se sebetse hantle. Kamora nako, batho ba sa tsubeng, ba sa batleng ho becha, ba tšoenyehile haholo, 'me ba na le litšitiso tsa botho bo sa hlonepheng le boiphetetso bo supang ho se sebetse hantle ha methapo ea kutlo.

Psychiatric comorbidity ke molao, eseng khethollo, ho batho ba nang le PG. Boithuto ba sechaba le ba bongaka bo thehiloeng tliliniking bo fana ka maikutlo a hore tšebeliso ea lithethefatsi, mathata a maikutlo le mathata a botho a atile haholo bathong ba nang le PG.78 Mo disampoleng tsa kliniki, ho tloha ho 25% ho isa ho 63% ea basomi ba methapo ea methapo ba kopana le maemo a bophelo bakeng sa bothata ba tšebeliso ea lithethefatsi.79 Ka mokhoa o ts'oanang, ho tloha 9% ho isa ho 16% ea ba sebelisang lithethefatsi ke boloi ba ka hlahang.79 PG e boetse e amahanngoa le ho ata ha mathata a ho feto-fetoha ha maikutlo ho feto-fetohang, 'me ka kakaretso 13% ho 78% ea batho ba nang le ts'ebeliso ea ho becha ha methapo ho nahanoa hore ba na le bothata ba ho feto-fetoha ha maikutlo.79 Ka lehlakoreng le leng, bakuli ba nang le mathata a ho feto-fetoha ha maikutlo ha ba na ho ba le litheko tse phahameng tsa PG.

Liphetho tsa mathata a mang a taolo ea tšusumetso e mpe (ICDs) a hlaha a phahame ho batho ba nang le papali ea ho becha ho feta ho

kakaretso. Bafuputsi ba tlalehile litheko tse tsoang ho 18% ho 43% bakeng sa ICD e le 'ngoe kapa ho feta.79 CB e bonahala e le ICD e atisang ho hlaha ka ho fetisisa ho batho ba nang le PG, mohlomong hobane mathata ao ka bobeli a arolelana litšobotsi tsa ho tsepamisa maikutlo, ho khotsofatsa ka chelete, le phapanyetsano ea chelete. Lihlooho tse nang le ICD e le 'ngoe li bonahala li na le monyetla o mong, li fana ka maikutlo a hore ho na le ho hongata ho ka etsoang har'a tsona.

Mathata a botho a atile haholo bathong ba nang le PG, haholo-holo ba leng sehlopheng sa "cluster B.". Ho re motho o na le kamano e haufi le PG, mohlomong hobane tlolo ea molao le papali ea chelete hangata li hlaha, ka litekanyetso tsa ho tloha 15% ho isa ho. 40%.79,80 Bonyane thuto e le 'ngoe ea batho ba nang le bothata ba ho hlonepha botho bo bonts'a litekanyetso tse phahameng tsa PG.81

PG e nahanoa ka bongata hore e sa foleng ebile e tsoela pele.82,83 Pono ena e kenelletse kahare DSM-IV-TR10 e ts'oereng hore karolo ea bohlokoa ea PG ke "boits'oaro bo phehellang le bo iphetang ba boitšoaro bo hlephileng ba ho becha… bo sitisang mesebetsi ea motho ka mong, ea lelapa kapa ea mosebetsi oa matsoho" (p 671). Maikutlo ana a ile a susumetsoa ke maikutlo a bo-pula-maliboho a Custer84 ea hlalositseng PG e le bokuli bo tsoelang pele, bo bongata bo qalang ka ho karolo e hapileng, ea lateloa ke a ho lahleheloa ke karolo, 'me e karolo ea ho tsieleha. Karolo ea ho qetela, ho inehela, e ne e emela maikutlo a ho hloka tšepo.85 Ba bang ba pheha khang ea hore batho ba bangata ba bapalang papali ea chelete ba "hlolang haholo" mathoasong a mesebetsi ea bona ea papali ea chelete e lebisang ho lemaleng ka kotloloho. Mekhahlelo e mene ea Custer ea PG e se e amoheloa ka bongata le ha ho se na tlhaiso-leseling e matla.

Mosebetsi oa morao-rao o lebisa ho hlahlobisisong ea maikutlo ana. LaPlante et al86 e hlahlobe lithuto tse hlano87-91 ba ileng ba kopana le litekanyetso tsa bona tsa ho tlaleha datha tse telele mabapi le ho becha tse sa kenyeng sampole ea kalafo. LaPlante et al o tlaleha hore, ho tsoa lithutong tse 'ne tse kenyelletsang papali ea chelete ea 3 (ke hore, batho ba nang le PG), barekisi ba bangata ba ntlafalitsoe,' me ba fetela maemong a tlase, le hore litefiso tsa ntlafatso ea sehlopha li "bonyane kholo haholo ho feta 29%. ”Liphetho li ne li tšoana ho boemo ba 2 (ke hore," kotsing ") ba bechang. Bao e neng e le maemo a 0 ho batšoaruoa ba 1 qalong ba ne ba se na monyetla oa ho hatela pele (ka ho teba, ho teba) boits'oaro ba papali ea chelete, 'me ntle ho khethollo e le' ngoe,91 lithuto li khothalelitse hore batšoaruoa ba fokolang ba 2 ba ntlafale ka ho fetela boemong ba 1. La Plante et al86 etsa qeto ea hore lithuto tsena li hanana le khopolo ea hore PG ha e khonehe, mme o fana ka maikutlo a hore batho ba bangata ba betang ba ntlafala ka boithatelo, joalo ka batho ba bangata ba lemaletseng lithethefatsi. Se fumanoeng se fana ka maikutlo a hore ba sa betang kapa ba becha ntle le mathata, ba lula ba le thata; ba nang le mathata a ho becha ba tloha boemong bo bong ho ea ho bo bong, leha tsela e akaretsang e leba sehlohlolong se ntlafalitsoeng.

Lintlha tsa nalane ea malapa li bontša hore PG, mathata a maikutlo le mathata a ts'ebeliso ea lithethefatsi a atile haholo bathong ba batho ba nang le PG ho feta ho bongata ka kakaretso.92,93 Boithuto ba morao-rao bo boetse bo fana ka maikutlo a hore papali ea chelete e na le karolo ea bohlokoa e ka etsoang.94 Liphuputso tse sebetsang tsa neuroimaging li bontša hore bathong ba nang le PG, papali ea papali ea chelete e tsosa takatso ea papali ea chelete le mokhoa o fetohileng oa ts'ebetso ea ts'ebetso ea boko maemong a ka pele, a paralimbic, le litho tsa bokong ba maoto, a fana ka maikutlo a hore boholo ba papali ea chelete bo ka emela ts'ebetso e sa sebetseng ea frontolimbic.95

Ho na le tumellano e fokolang mabapi le kalafo e loketseng ea PG. Ke batho ba fokolang ba nang le PG ba batlang kalafo,96 mme ho fihlela haufinyane kalafo ea mantlha ea kalafo e bonahala e nka karolo ho Gambler Anonymous (GA), lenaneo la bohato ba 12 le etselitsoeng kamora Alcoholics Anonymous. Ho ba teng GA mahala ebile likhaolo li fumaneha hohle US, empa tse latelang ha li na litekanyetso tse ntle le katleho.97 Mananeo a phekolo ea nako e telele le a ntlafatso a tšoanang le a mafu a tšebeliso ea lithethefatsi a se a qapiloe, 'me a thusa ba bang98,99 Leha ho le joalo, mananeo ana ha a fumanehe ho batho ba bangata ba nang le PG ka lebaka la jogi kapa ho haelloa ke phihlello (ke hore, inshorense / lisebelisoa tsa lichelete). Haufinyane tjena, lipotso tsa CBT le lipuisano tse susumetsang li se li thehiloe mekhoa ea kalafo.100 Mananeo a ho itšehla thajana a fumane kamohelo hape ho bonahala a tsoela molemo bakuli ba khethiloeng.101 Le ha melao e fapana, ka kakaretso e kenyelletsa ho itšehla thajana ka boithaopo ka nako e itseng kotsing ea ho tšoaroa ka lebaka la tlolo ea molao. Lithuto tsa kalafo ea kalafo ea meriana li fumanehile haholo, empa litholoana tsa tsona ha li lumellane. Ka bokhutšoanyane, bahanyetsi ba opioid naltrexone le nalmefene ba ne ba phahame ho feta placebo litekong tse laoloang ka mokhoa o ikhethileng (RCTs)102,103 empa liteko tse laoloang tsa paroxetine le bupropion li ne li le mpe.104,105 Lithuto tse bulehileng ka lebitso la nefazodone, citalopram, carbamazepine, le escitalopram li khothalelitse, empa li hloka ho lateloa ka lithuto tse matlafalitsoeng hantle le tse laoloang.106-109

Kamano e tsitsitseng lipakeng tsa CB / PG le OCD

Kamano e pakeng tsa CB / PG le OCD e lula e sa tsejoe. Ho kenyelletsoa ha CB le PG ka har'a setšoantšo sa OC, le ha e le ntho e khahlang, e itšetleha ka tlhahisoleseling eseng data e hlasimollang. Hore na mathata ana a lokela ho khetholloa joang ho 'nile ha buisanoa ka lilemo tse ka bang 100. Maikutlo a ratile haholo-holo ho kenyelletsoa ha bona har'a mathata a taolo ea litšusumetso. Bakeng sa mabaka a nalane, hape ka lebaka la khaello ea tlhaiso-leseling e matla, re lumela hore mathata ana a mabeli a lokela ho lula le li-ICD ho fihlela ho fanoa ka bopaki bo kholisang ba ho kenyelletsa ho kenyelletsa ha bona ka mathata a tlhekefetso kapa setšoantšo sa OC.

Khokahano e hlakileng ka ho fetisisa lipakeng tsa CB le PG le OCD ke phenomenologic. Boloetse bo bong le bo bong bo kenyelletsa boits'oaro bo pheta-phetoang boo hangata bo hlahang ho arabela mehopolo e matla le litakatso; ho etsa boits'oaro - bonyane ka nakoana - ho tla khotsofatsa takatso, le / kapa ho fokotsa tsitsipano le matšoenyeho a tlileng pele ho boitšoaro. Leha ho le joalo, phapang ea mantlha lipakeng tsa CB / PG le OCD ke hore boits'oaro (mabenkeleng, papali ea chelete) bo nkuoa ego-syntonic; ka mantsoe a mang, ba talingoa e le tse khahlisang le tse lakatsehang, ha boits'oaro bo amanang le OCD bo sa be joalo, 'me hoo e ka bang bakuli bohle ba batla ho ba tlosoa. Ha ho joalo ka mabenkele le papali ea chelete: motho ea nang le CB kapa PG o fumana boitšoaro bo khahlisa haholo, 'me o mpa a batla ho emisa boitšoaro ha litlamorao tsa bona tse mpe li fetoha tse kholo. Baloaneli ba pono ea OC ba supa pharalletseng lipakeng tsa mathata ana le OCD. Lithuto tsa Comorbidity li fumane hore ka har'a disampole tsa kliniki ho tloha 3% ho 35% ea batho ba nang le CB ba na le comorbid OCD.22,46 Ebile, boteng ba CB bo ka supa mofuta o ikhethileng oa bakuli ba OCD,110,111 haholoholo ba ts'oarellang. Hoarding ke letšoao le ikhethang le kenyelletsang ho fumana le ho se khone ho lahla, thepa e sa sebelisoeng kapa ea boleng bo fokolang.112 Leha ho le joalo, ho fapana le lintho tse bolokiloeng ke motho ea tloaelehileng oa motlakase, lintho tse rekiloeng ke motho ea nang le CB ha li na thuso ea tlhaho ebile ha li na thuso.

Hangata hangata ho bonahala eka li-comorbid le li-ICD. E Ntsho le Moyer80 le Grant le Kim72 e mong le e mong o tlaleha litheko tse phahameng tsa CB hara lisampole tsa bashemane ba li-pathological (23% le 8%, ka ho latellana). Ka mokhoa o ts'oanang, mathata a mang a taolo a susumetsang a tloaelehile har'a bareki ba qobelloang.39 Lithuto tsa Comorbidity tsa PG li tsoakane, leha ho le joalo ka kakaretso li tlaleha litheko tse phahameng tsa OCD ho feta ho bongata ka kakaretso. Ha ho potang, ho bonahala eka ha se 'nete. Papiso ea Axis II e bonts'a hore mafu a mantlha a amanang le OCD ke mafu a "Cluster" ". Le ha ho se na mathata a axis II a amanang ka kotloloho le PG kapa CB, mathata a "cluster B" a hlaha a fetelletse, haholo-holo ho hloka botho ha motho.

Patlisiso e tobileng mabapi le litšobotsi tsa OC tsa batho ba nang le PG e fumane hore ba nang le PG ba phahame haholo ho feta ba se nang likala tse lekanyang litšobotsi tsa OC.64 CB le PG le tsona li arolelana litšusumetso tse phahameng tsa boitšoaro.19,113

Bopaki bo bong bo ka tsoa lithutong tsa lelapa tsa CB, PG, kapa OCD. Ho na le lithuto tse fokolang tsa malapa tse amanang le mathata ana, 'me ha ho na ea tšehetseng kamano ea lelapa har'a mafu ana. Phuputsong e le 'ngoe feela e laoloang ea lelapa ea CB, Black et al45 ha a ka a fumana kamano le OCD. Lithutong tse peli tsa malapa, e 'ngoe e sebelisa mokhoa oa nalane ea lelapa, e' ngoe e sebelisa mokhoa oa puisano ea lelapa, bafuputsi ba sitiloe ho theha khokahano lipakeng tsa PG le OCD.114,115

Ha re sheba khokahano ena ka lithuto tsa lelapa la OCD hape e hlotsoe ho fumana khokahano. Leha ho le joalo, Black et al114 kapa Bienvenu et al115 ba khonne ho theha kamano ea lelapa pakeng tsa OCD le PG.

Ho ts'oana ha demographic hangata ho sebelisetsoa ho fana ka maikutlo a hore mathata a ka hokahana, mohlala, 'nete ea hore likotsi tsa joala le bokhopo ba batho ba khetholloang haholo li fumanoa ho banna. Leha ho le joalo, ha ho na ho tšoana ho ajoa ka bong pakeng tsa mafu ana. Ka PG ho na le tokafatso e hlakileng ea monna; ka CB preonderance ea basali; le OCD, kabo ea bong e arotsoe ka mokhoa o tšoanang.

Haeba mathata ana a ne a amana, nalane ea 'ona ea tlhaho le tsela ea' ona e kanna ea ba joalo. CB le OCD li bonahala li na le ho qaleha ho isa lilemong tsa bocha kapa li-20 tsa pele. PG e bonahala e na le ho qaleha hanyane ka hanyane, mme basali ba nts'etsapele lefu lena kapele ho feta banna, empa ho ba le thuto e khuts'oane ho tloha qalong ea papali ea papali ea chelete ho ea ho nts'etsopele ea bokuli. Sena ke se bonoang ka mathata a joala, empa eseng OCD. Ka CB, PG, le OCD kaofela ha tsona li nkuoa e le tse sa feleng, empa ho tšoana ho emisa moo. Bakeng sa CB le PG, leha ho se na lithuto tse hlokolosi, tsa tlhaiso-leseling, tlhaiso-leseling e fana ka maikutlo a hore mathata ao e ka ba episodic, ka mantsoe a mang, a ka hlakoloa ka bolelele ba nako ho latela bongata ba lintlha tse kantle tse kang ho tšaba lits'ebetso, mohlala. kapa tlhalo, kapa ho hloka chelete; OCD ha e phete. Mabapi le kotsi ea ho ipolaea, PG e tlaleha hore e na le kotsi ea liteko tsa ho ipolaea le ho ipolaea ho tlatsitsoeng; le CB, ho na le litlaleho tsa makolopetso a ho leka ho ipolaea, empa a sa ipolaee; le OCD, ya data e tsoakane, empa ka kakaretso, kotsi ea ho ipolaea e felletseng e nkuoa e le tlase.

Le mona, ha motho a nahana ka karabo ea kalafo, OCD e tsejoa haholo ho arabela hantle ho li-antidepressants tsa serotonin reuptake inhibitor, le kalafo ea boits'oaro ea kelello. CB le PG ha li na karabelo e hlakileng kalafong, 'me tlhaiso-leseling e matla ka ho fetisisa ea kalafo e bontša hore PG e ka arabela ho bahanyetsi ba opioid. Ka bobeli CB le PG ho tlalehoa hore li arabela ho CBT, empa phetheho le boleng ba karabelo ha bo tšoane le bo bonoang ka OCD.

Ho ba teng ha matšoao a tšoanang a bioloji ke tsela e 'ngoe ea ho lekola khokahano lipakeng tsa mafu ana. Mosebetsi ona o sitisoa ke hore ha ho le e 'ngoe ea mathata ana e nang le matšoao a tšepahalang. Leha ho le joalo, patlisiso ea ts'ebetso ea matla a matla a matla a matla a sefahleho (FMRI) ea tšebetso ea PG e fana ka maikutlo a hore lefu lena le bontša ts'ebetso e sa tloaelehang libakeng tse ikhethileng ka mor'a ho pepesetsoa. Potenza et al86 fetolela lipatlisiso tsena e le bopaki ba ho ts'oana ha tsela ea boko ho PG le bokhoba ba lithethefatsi, athe lehlakoreng le leng la ts'ebetso e phahameng ea ts'ebetso ea ts'ebetso e fumanoa ho OCD. Ka mokhoa o ts'oanang, Goodriaan et al116 lekola lipatlisiso mabapi le tlhaiso-leseling ea lefutso ea methapo ea kutlo le limolek'hule tse amanang le PG. Ba fihlela qeto ea hore ho na le bopaki ba ts'oaetso ea methapo ea kutlo e amanang le dopamine (DA), serotonin le norepinephrine; mme "… li ipapisitse le se fumanoeng ke ts'ebetso e sa tloaelehang ea boko litseleng tsa meputso, moo DA e leng se fetisang sa bohlokoa" (p 134). Dopamine e tsejoa e bapala karolo ea bohlokoa ho lakatseng le ho ikhula mathateng a ts'ebeliso ea lithethefatsi. Le ha phetiso ea methapo ea kutlo e amehang ho OCD e sa hlakisoe ka botlalo, sisteme e bohareng ea serotonin e bile eona e ithutiloeng ka mafolofolo. Mohlomong ke ka lebaka la phello e matla ea li-SSRI kalafong ea OCD.

Ka kakaretso, lithuto tsa neuropsychological tsa PG li bonts'a hore basomi ba methapo ea methapo ba sitisitse ts'ebetso maemong a fapaneng a ts'ebetso ea botsamaisi ho kenyelletsa tlhokomelo, ho theola litheko le ho etsa liqeto.115-117 Ka OCD, lipatlisiso tsa neuropsychological ha li lumellane haholo; ho na le bopaki ba ho sitisoa ha karabo le ho feto-fetoha ha maikutlo, empa ho na le bopaki bo fokolang ba ho ithuta le ho etsa liqeto ka tsela e fosahetseng.118 Ho tsebo ea rona, ha ho na lithuto tsa neuropsychological tsa batho ba nang le CB.

Merero e meng ea khethollo

Haeba CB le PG e se karolo ea sebopeho sa OC, ba lokela ho khetholloa kae? Hobane ha ho na bopaki bo fanang ka maikutlo a kamano le mathata a maikutlo, ho ka etsahala hore monyetla ona o ka felisoa ka ho hlaka. Ho merero e setseng, ba khethang ho fetisisa ke ho kenyelletsa PG le CB le li-ICD, kapa ho ba isa sehlopheng se kenyeletsang mathata a ts'ebeliso ea lithethefatsi.

Ho boloka PG le CB le li-ICD ke khetho e bonolo ka ho fetisisa: PG e se e khethiloe e le ICD, athe CB ha e sa kenyelletsoa ho DSM-IV-TR, e kile ea nkoa e le bothata bo sa reroang. Ka bobeli PG le CB li arolelana likarolo tse tšoanang tsa kliniki tse kenyelletsang ho ba teng ha maikutlo a ke keng a qojoa, a tlhaho a susumetsang karabelo. Karabelo (ke hore, papali ea chelete, ho ea mabenkeleng) e khotsofatsa maikutlo le / kapa ka nakoana e fokotsa tsitsipano kapa matšoenyeho, empa hangata e lateloa ke letsoalo la molato kapa lihlong, 'me qetellong e lebisa litlamorao tse mpe. Boitšoaro bo bobebe kapa bo nakoana, 'me bo ka hlakoloa ka boithatelo, ka linako tse ling ho arabela maemong a kantle. Nako ea peleho le kabo ea bong e fapana, joalo ka ha ho boletsoe pejana. Mohlomong, CB e kanna ea nkuoa e le basali ba tšoanang le PG, hobane ba tloaetse ho ba le phetisetso e fapaneng ea bong: banna ba atileng haholo ho ba nang le PG; basali ke bona ba ka sehloohong ho ba nang le CB. Ka bobeli ba bonahala ba arabela ho CBT, leha ho le joalo ha ba na karabelo e hlakileng kalafong; Li-SSRI ha li hlahise ntlafatso e sa fetoheng. Lithuto tsa Comorbidity li bontša ho ata hara mathata a, kaha palo e sa lekanang ea ba bechang ea methapo ea methapo ba le CB le ho fapana.

Ka lehlakoreng le leng, data e fana ka maikutlo a amanang le mathata a ts'ebeliso ea lithethefatsi. PG le CB ka bobeli li amana le litakatso tse sa fapaneng le tse tlalehiloeng ke batho ba hlekefetsang lithethefatsi; PG e tsejoa e hlahisa matšoao a "ho khaola" ha motho ea tsubang a sa thijoe,119 leha sena se sa ithutoe ho CB. Patlisiso e bonts'a hore batho ba nang le PG kapa CB hangata ba na le mathata a ts'ebeliso ea lithethefatsi tsa comorbid. Ka lehlakoreng le leng, ba hlekefetsang lithethefatsi ba na le litheko tse phahameng tsa PG; ha ho na data e ka bapisoang le ea CB. Lithuto tsa lelapa li bonts'a hore beng ka mathata a PG kapa CB ba na le maemo a mangata a bokuli ba kelello, haholo joala le ts'ebeliso ea lithethefatsi. Ho feta moo, Slutske et al94 ba tlalehile hore, ho ipapisitse le data ea mafahla, PG e bonahala e amana le bothata ba tšebeliso ea lithethefatsi le bokuli ba botho bo sa rateheng. Qetellong, joalo ka ha ho boletsoe pejana, lithuto tsa neuroimaging, le lipatlisiso tsa liphatsa tsa lefutso le lipatlisiso tsa liphatsa tsa lefutso ho PG li fana ka maikutlo a kamano le mathata a ts'ebeliso ea lithethefatsi.116 Lintlha tsena li tšehetsa ho kenyelletsoa ha PG mohlomong le CB sehlopheng sa "bokhoba ba boits'oaro," mohlomong bo nang le mathata a ts'ebeliso ea lithethefatsi, empa ha a tšehetse kamano le OCD.

Nahanisisa

Tlhahlobo e fana ka maikutlo a hore CB le PG mohlomong ha se baemeli ba ho kenyelletsoa ponts'o ea OC. Tlhahlobo e ne e sa rereloa ho ahlola boleng ba mohopolo oa bonohe ba OC.

Ebile, re khothalelitse hore ho bonahale ho na le bopaki bo lekaneng ho ts'ehetsa boteng ba palo e lekanyelitsoeng ea OC e ka kenyelletsang lefu la 'mele dysmorphic, lefu la Tourette, trichotillomania, OCD ea bongaka, mohlomong le mathata a boitlhopho.8,120 Le ha ho na le ho ts'oana ho makatsang ka ho tšoana pakeng tsa CB / PG le OCD, bopaki bo bong bo supa hore ha bo amane: ho abuoa ka bong, lilemo ho qala, le nete; lithuto tsa comorbidity; neuroimaging, neurotransmitter, le lithuto tsa neuropsychological; le karabelo ea kalafo. Re lumela hore PG le CB li ka amana, leha ba arohantsoe haholo ka bong. Ho feta moo, re lumela hore ha ho se na bopaki bo bocha le bo kholisang, PG e tlameha ho lula kahare ho sehlopha sa ICD. Qetellong, re lumela hore CB ke ts'oaetso e khethollang le e ikhethileng e lokelang ho kenyelletsoa ho DSM-5, hape e lokela ho kenyelletsoa le li-ICD.

Likarolo tse khethiloeng le litlhaloso

  • CB
  • ho qobella ho reka
  • ICD
  • tšusumetso ea taolo ea tšusumetso
  • OC
  • e qobellang-e qobella
  • OCD
  • boloetse bo feteletseng-bo qobelloang
  • PG
  • papali ea papali ea chelete
  • SSRI
  • selenar selenak selena selenak

LITLHAHISO

1. Hollander E. Mathata a amanang le a qobelloang. Washington DC: American Psychiatric Press 1993
2. Hollander E. Litšitiso tse bonts'ang maikutlo tse hlokisang botsitso: kakaretso. Psychiatr Ann. 1993; 23: 355-358.
3. Hollander E, Wong CM. Kenyelletso: Lits'oaetso tsa bonohe tse bonoang. J Clinic Psychiatry. 1995; 56 (suppl 4): 3-6. [E fetotsoe]
4. Koran LM. Matšoenyeho a Feteletseng le a Amanang le Batho ba baholo - Tataiso e felletseng ea bongaka. New York NY Cambridge UK 1999
5. Rasmussen SA. Mathata a bonoheng a shebellehang. J Clinic Psychiatry. 1994; 55: 89-91. [E fetotsoe]
6. Castle DJ, Phillips KA. Pontsho e hlokisang mahlo-kholo ea likhathatso: moaho o nyenyefatsang? Psychology ea Aust NZ J. 2006; 40: 114-120. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
7. Tavares H, Gentil V. Papali ea papali ea chelete le bosholu bo hlokisang tšusumetso: ho isa sehlohlolong sa mathata a boithati. Rev Brasil Psiquiatria. 2007; 29: 107-117. [E fetotsoe]
8. DW e ntšo. Sebopeho se bonts'ang: na ke 'nete kapa ke feshene? Ka: Maj M, Sartorius N, Okasha A, Zohar J, eds. Matšoenyeho a Tšoenyehileng-a Mangata. New York, NY: Wiley 2000: 233-235.
9. Phillips KA. Ponahalo e sa bonahaleng: Litšepiso le likotsi. Ka: Maj M, Sartorius N, Okasha A, Zohar J, eds. Matšoenyeho a Tšoenyehileng-a Mangata. New York, NY: Wiley 2000: 225-227.
10. Mokhatlo oa Maiketsetso oa Amerika. Buka ea ho hlahloba le ea Statistical ea Mathata a kelello. 4th ed, Phetolelo ea Mongolo. Washington, DC: Mokhatlo oa Amerika oa Psychiatric 2000
11. Robins E. Guze SB. Ho thehoa hoa netefatso ea tlhahlobo ea mafu a mafu a kelello: ts'ebeliso ea eona ho schizophrenia. Am J Psychiatry. 1970; 126: 983-987. [E fetotsoe]
12. Mokhatlo oa Lefatše oa Bophelo. Kemiso ea Machaba ea Maloetse. Tlhatlhobo ea 9th. Geneva, Switzerland: Mokhatlo oa Lefatše oa Bophelo 1977
13. Zohar J. Setifikeiti sa Consensus Group Cape Town Consensus Statement for Obsessive-Compulsive Spectrum to Obsessive Compulsive Disrupt: Polelo ea Cape Town Consensus. CNS Spectr. 2007; 12: 2 (suppl 3): 5-13. [E fetotsoe]
14. Lee S, Mysyk A. Tlhahiso ea bongaka ea ho reka ka matla. Soc Sci Med. 2004; 58: 1709-1718. [E fetotsoe]
15. Holden C. Boitšoaro ba Boitšoaro: kahoo li teng? Science. 2001; 294: 980-982. [E fetotsoe]
16. Kraepelin E. Psychiatrie. 8th ed. Leipzig, Jeremane: Verlag Von Johann Ambrosius Barth 1915: 408-409.
17. Bleuler E. Sengoloa sa Psychiatry. AA Brill, Trans. New York, NY: Macmillan 1930
18. Esquirol JED. Des mafu a likotsi. Paris, Fora: Baillière 1838
19. O'Guinn TC, Faber RJ; Mosebetsi Ho reka ka qobello: tlhahlobo e makatsang. J Consumer Res. 1989; 16: 147-157.
20. Elliott R. Ts'ebeliso e tlatsetsang: ts'ebetso le likhathatso ho postmodernity. J Leano la Bareki. 1994;17:1 59–179.
21. Magee A. Ho tloaela ho reka ka mokhoa o ikhethileng e le 'moleli oa maikutlo le maikutlo. Adv Consum Res. 1994; 21: 590-594.
22. McElroy S, Keck PE, Mopapa HG, et al. Ho reka ka mokhoa o qobelloang: tlaleho ea linyeoe tsa 20. J Clinic Psychiatry. 1994; 55: 242-248. [E fetotsoe]
23. McElroy S, Satlin A, Mopapa HG, et al. Phekolo ea mabenkele a qobelloang le li-antidepressants: tlaleho ea linyeoe tse tharo. Ann Clin Psychiatry. 1991; 3: 199-204.
24. Christenson GA, Faber RJ, de Zwaan M, et al. Ho reka ka mokhoa o qobelloang: litšobotsi tse hlalosang le ho hlasimoloha ha kelello. J Clinic Psychiatry. 1994; 55: 5-11. [E fetotsoe]
25. Schlosser S, Black DW, Repertinger S, Freet D. Ho reka ka mokhoa o qobelloang: demographic, phenomenology, le comorbidity lithutong tsa 46. Gen Hosp Psychiatry. 1994; 16: 205-212. [E fetotsoe]
26. Faber RJ, O'Guinn TC. Sesepa sa ho hlahloba bophelo ba motho ka sehlōhō ha a reka. J Consumer Res. 1992: 459-469.
27. Edward EA. Nts'etsopele ea sekhahla se secha sa ho lekanya boitšoaro bo potlakileng ba ho reka. Moralo oa Tlhahiso ea Fin. 1993; 4: 67-84.
28. Dittmar H. Ho utloisisa le ho khetholla ho reka ho tlamang. Ka: Coombs R, ed. Mathata a Tlatsetsang. Buka e Sebetsang. New York, NY: Wiley 2004: 411-450.
29. Bintha MC, Griffin TF. Liphatlalatso le litlamorao tsa boitšoaro bo bobe ba bareki. Papatso ea Psychol. 1996; 13: 739-740.
30. Hollander E, Allen A. Na ho reka ka mokhoa o qobellang ke pherekano ea 'nete mme ho hlile hoa qobelloa? Am J Psychiatry. 2006; 163: 1670-1672. [E fetotsoe]
31. Lejoyeux M, Andes J, Tassian V, Solomon J. Phenomenology le psychopathology ea theko e sa laoloang. Am J Psychiatry. 1996; 152: 1524-1529. [E fetotsoe]
32. Glatt MM, Cook CC. Tšebeliso ea chelete ha e le mokhoa oa ho its'etleha kelellong. Br J Addict. 1987; 82: 1252-1258. [E fetotsoe]
33. Goldman R. Ho reka ka mokhoa o qobelloang joalo ka lekhoba la tahi. Ka: Benson A, ed. Ke ea reka, ke ka hona ke rekang: Ho reka ka thata le ho ipatlela. New York, NY: Jason Aronson 2000: 245-267.
34. DW e ntšo. Boloetse bo tlamang ba ho reka: Tlhaloso, tlhahlobo, lefu la mafu le tsamaiso ea bongaka. Lithethefatsi tsa CN S. 2001; 15: 17-27. [E fetotsoe]
35. McElroy SE, Mopapa HG, Keck PE, et al. A mathata a taolo a a tlhotlheletsang a a amanang le bolwetse jwa go fetofetoga? Compr Psychiatry. 1996; 37: 229-240. [E fetotsoe]
36. Koran LM, Faber RJ, Aboujaoude E, et al. Keketseho e atileng ea theko e qobelloang United States. Am J Psychiatry. 2006; 163: 1806-1812. [E fetotsoe]
37. Grant JE, Levine L, Kim SW, Potenza MN. Phokotso ea taolo ea tšusumetso ho lipilisi tsa kelello tsa batho ba baholo. Am J Psychiatry. 2005; 162: 2184-2188. [E fetotsoe]
38. DW e ntšo. Epidemiology le phenomenology ea khatello e theko e phahameng ea ho reka. Ka: Grant J, Potenza M, eds. Oxford Handbook of Impulse Control Disrupt
39. DW e ntšo. Khatello e matla ea ho reka: ho hlahloba bopaki. Libaka tsa CNS. 2007; 12: 124-132. [E fetotsoe]
40. Otter M, DW e ntšo. Boitšoaro bo matla ba ho reka ho batho ba babeli ba nang le bothata. Prim Care Companion J Clin Psychiatry. 2007; 9: 469-470. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
41. Dittmar H. Ha motho a le betere o penya feela konopo pakeng tsa boleng ba ho rata lintho tse bonahalang, sepheo sa ho reka le maikutlo a amanang le boitsebahatso, le tšekamelo ea ho reka e kenelletseng inthaneteng. J Soc Clin Psychol. 2007; 26: 334-361.
42. Nataraajan R, Goff BG. Ho reka ka tieo: ho fihlela poelanong. J Motho oa Behav. 1991; 6: 307-328.
43. Aboujaoude E, Gamel N, Koran LM. Tlhahlobo ea tlhaho ea 1 ea selemo sa tlhaho ea bakuli ba nang le mathata a ho qobella ho reka. J Clinic Psychiatry. 2003; 64: 946-950. [E fetotsoe]
44. Lejoyeux M, Tassian V, Solomon J, Ades J. Boithuto ba ho reka ka tieo ho batho ba tepelletseng maikutlo. J Clinic Psychiatry. 1997; 58: 169-173. [E fetotsoe]
45. Black DW, Repertinger S, Gaffney GR, Gabel J. Nalane ea lelapa le maikutlo a kelello ho batho ba rekang ka mokhoa o qobelloang: liphetho tsa pele. Am J Psychiatry. 1998; 155: 960-963. [E fetotsoe]
46. DW e ntšo, Monahan P, Gabel J. Fluvoxamine kalafong ea ho reka ka phehello. J Clinic Psychiatry. 1997; 58: 159-163. [E fetotsoe]
47. DW e ntšo, Gabel J, Hansen J, et al. Papiso e sa boneng habeli ea fluvoxamine le phallo ea placebo kalafong ea bothata bo sa rekoeng ba ho reka. Ann Clin Psychiatry. 2000; 12: 205-211. [E fetotsoe]
48. Ninan PT, McElroy SL, Kane CP, et al. Phuputso e laoloang ke placebo ea fluvoxamine kalafong ea bakuli ba rekang ka potlako. J Clinic Psychopharmacol. 2000; 20: 362-366. [E fetotsoe]
49. Koran LM, Chuang HW, Bullock KD. Smith SC Citalopram bakeng sa bokuli bo qobelloang ho ea mabenkeleng: thuto e bulehileng-label e lateloang ke ho khaoloa ha mahlo a mabeli. J Clinic Psychiatry. 2003; 64: 793-798. [E fetotsoe]
50. Koran LM, Aboujaoude EN, Solvason B, Gamel N, Smith EH. Escitalopram bakeng sa bokuli bo qobelloang ho reka: thuto ea ho khaotsa mahlo a mabeli. J Clinic Psychopharmacol. 2007; 27: 225-227Letter. [E fetotsoe]
51. Grant JE. Nyeoe tse tharo tsa theko e qobelloang li phekoloa ka naltrexone. Int J Psychiatry Clin Prac. 2003; 7: 223-225.
52. Neuner M, Raab G, Reisch L. Ho reka ka mokhoa o qobellang mekhatlong ea bareki: ho botsa botjha. J Econ Psychol. 2005; 26: 509-522.
53. Krueger DW. Mabakeng a ho reka le ho qhekella ka matla: tlhahlobo ea kelello. Ke J Psychother. 1988; 42: 574-584. [E fetotsoe]
54. Lawrence L. Lingoloa tsa kelello tsa morekisi ea tlamang oa basali. Ke J Psychoanal. 1990; 50: 67-70. [E fetotsoe]
55. Winestine, lebenkele le qobelloang la MC ke ntho e tsoang leratong la bongoaneng. Psychoanal Q. 1985; 54: 70-72. [E fetotsoe]
56. Villarino R, Otero-Lopez JL, Casto R. Adicion a la compra: Tlhahlobo, tlhatlhobo y tratamiento [Reka ho reka: Tlhatlhobo, tekolo, le kalafo] Madrid, Spain: Ediciones Piramide 2001
57. Mitchell JE, Burgard M, Faber R, Crosby RD. Phekolo ea boits'oaro ea kelello bakeng sa bokuli bo qobelloang ke ho reka. Behav Res Ther. 2006; 44: 1859-1865. [E fetotsoe]
58. Benson A. Stopping Overshopping - Lenaneo le Akaretsang la ho Thusa ho Felisa Ho Tebella. New York, NY: April Benson 2006
59. Setsi sa Patlisiso ea Maikutlo a Sechaba Univesithing ea Chicago (NORC): Phello ea Papali ea Chelete le Boitšoaro, Tlaleha ho Khomishene ea Tlhahlobo ea Lipapatso tsa Naha. April 1, 1999
60. Petry NM, Kiluk BD. Mehopolo ea ho ipolaea le liteko tsa ho ipolaea ho batho ba batlang ho tsuba ba tsubang. J Nerv Ment Dis. 2002; 190: 462-469. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
61. Shaw M, Forbush K, Schlinder J, et al. Litlamorao tsa ho becha ha methapo ea methapo ho malapa, manyalo le bana. CNS Spectr. 2007; 12: 615-622. [E fetotsoe]
62. Mokhatlo oa Maiketsetso oa Amerika. Buka ea ho hlahloba le ea Statistical ea Mathata a kelello. 3rd ed. Washington, DC: Mokhatlo oa Amerika oa Psychiatric 1980
63. Shaffer HJ, Hall MN. Ho hakanya ho ata ha mathata a papali ea bohlankana ba lilemong tsa bocha: tloaelo le tataiso e lebisang tlhokomelong e tloaelehileng ea papali ea papali ea chelete. J ho bapala liithuti. 1996; 12: 193-214.
64. Blaszczynski A. Ho becha ho hoholo le ho se sebetse hantle ha sefahleho. Psychol Rep. 1999; 84: 107-113. [E fetotsoe]
65. Durdle H, Gorey KM, Stewart SH. Tlhahlobo ea "meta" e lekolang likamano lipakeng tsa papali ea papali ea methapo ea methapo, pherekano e kenelletseng, le litšobotsi tse lemosang. Psychol Rep. 2008; 103: 485-498. [E fetotsoe]
66. Shaffer HJ, LaPlante DA, LaBrie RA, et al. Mabapi le mohlala oa ho lemalla: litlhaloso tse ngata, etiology e tloaelehileng. Har Rev Psychiki. 2004; 12: 367-374. [E fetotsoe]
67. Wray I, Dickerson MG. Ho khaotsa ho tsuba hangata le matšoao a bang teng ha motho a khaotsa ho tsuba. Br J Tlatsetso. 1981; 76: 401-405. [E fetotsoe]
68. Shaffer HJ, Hall MN. Ho nchafatsa le ho nchafatsa litekanyetso tsa boitšoaro bo hlephileng ba papali ea chelete United States le Canada. Na J Pub Health. 2001; 92: 168-172. [E fetotsoe]
69. Cunningham-Williams R, Cottler LB. Pale ea mafu a ho becha ha methapo ea methapo. Sem Clin NeuroPsychiatry. 2001;6:1 55–166.
70. Volberg RA. Lithuto tsa esale pele tsa bothata ba ho becha United States. J Ho Ithuta Ho Becha. 1996; 12: 111-128.
71. Jacques C, Ladouceur R, Gerland F. Tšusumetso ea ho fumaneha papaling ea chelete: thuto e telele. Na J Psychiatry. 2000; 45: 810-815. [E fetotsoe]
72. Grant J, Kim SW. Lipalo tsa batho ba bangata le ba bongaka ba 131 ea ba bechang. J Clinic Psychiatry. 2001; 62: 957-962. [E fetotsoe]
73. Tavares H, Zilberman ML, Beites FJ, et al. Phapang pakeng tsa botona le botšehali tsoelo-peleng ea papali ea chelete. J ho bapala liithuti. 2001; 17: 151-159. [E fetotsoe]
74. Potenza MN, Kosten TR, Rounsaville BJ. Ho becha ka tsela ea tlhaho. JAMA. 2001; 286: 141-144. [E fetotsoe]
75. Templer Dl, Kaiser G, Siscoe K. Lits'ebetso tsa methapo ea ho becha ea methapo ho batšoaruoa ba chankana. Compr Psychiatry. 1993; 34: 347-351. [E fetotsoe]
76. Blaszczynski A, McConaghy N. Ho tšoenyeha le / kapa khatello ea maikutlo ho pathogeneis ea papali ea papali ea chelete. Int J Litlatsetso. 1989; 24: 337-350. [E fetotsoe]
77. Blaszczynski A, Nower L. Mohlala oa bothata le papali ea papali ea chelete. lemalla ntho e. 2002; 97: 487-499. [E fetotsoe]
78. Crockford ND, el-Guebaly N. Psorchiatric comorbidity ho tsibollo ea methapo ea methapo: tlhahlobo e boima. Am J Psychiatry. 1998; 43: 43-50. [E fetotsoe]
79. DW e ntšo, Shaw M. Psychiatric comorbidity le ho becha ha methapo. mafu a kelello Times. 2008; 25: 14-18.
80. DW e ntšo, Moyer T. Litlhare tsa kliniki le comorbidity ea kelello lithutong tsa 30 tse tlaleha boitšoaro ba ho becha ba pathological. Sebeletso sa Psychiatr. 1998; 49: 1434-1439. [E fetotsoe]
81. Goldstein RB, Powers SI, McCusker J, et al. Ho haelloa ke letsoalo ho tlhekefetso ea botho ho batho ba sebelisang lithethefatsi ka kalafo ea bolulo. J Pers Disord. 1996; 10: 321-334.
82. Cartwright C, DeCaria C, Hollander E. Lipapali tsa ho becha: Tlhahlobo ea bongaka. J Prac Psychiatr Behav Health. 1998; 5: 277-286.
83. DeCaria C, Hollander E, Grossman R, et al. Tlhahlobo ea kelello, lefu la ramatiki le kalafo ea papali ea papali ea chelete. J Clinic Psychiatry. 1996; 57 (suppl 8): 80-84. [E fetotsoe]
84. Custer R. Ha Luck A felloa ke Mosebetsi. New York, NY: Lintlha ho File 1985: 232.
85. Ho becha ka Rosenthal R. Psychiatr Ann. 1992; 22: 72-78.
86. LaPlante DA, Nelson SE, LaBrie RA, Shaffer HJ. Botsitso le tsoelo-pele ea papali ea chelete e sarolloang: lithuto tse tsoang lithutong tse telele. Na J Psychiatry. 2008; 53: 52-60. [E fetotsoe]
87. Abbott MW, Williams MM, Volberg RA. Phuputso e lebelletsoeng ea bothata le barekisi ba se nang bothata ba kamehla ba lulang sechabeng. Sebelisa hampe. 2004; 39: 855-884. [E fetotsoe]
88. DeFuentes-Merillas L, Koeter MW, Schippers GM, van den Brink W. Ho tsitsitseng ha nakoana bakeng sa papali ea chelete ea boloi ho tse rekisoang har'a batho ba baholo ba rekang likarete tsa batho ba baholo lilemo tse peli hamorao. lemalla ntho e. 2004; 99: 117-127. [E fetotsoe]
89. Shaffer HJ, Hall MN. Nalane ea tlhaho ea mathata a papali ea chelete le ho nosetsa har'a basebetsi ba li-casino. J Ps Psychol. 2002; 142: 405-424. [E fetotsoe]
90. Slutske W, Jackson KM, Sher KJ. Nalane ea tlhaho ea ho becha ha mathata ho tloha botsofaling ba 18 ho isa 29. J Abnorn Psychol. 2003; 112: 263-274. [E fetotsoe]
91. Winters KC, Stinchfield RD, Botzet A, Anderson N. Phuputso e lebelletsoeng ea boitšoaro ba papali ea bacha. Psychol Addict Behav. 2002; 16: 3-9. [E fetotsoe]
92. Black DW, Moyer T, Schlosser S. Boleng ba bophelo le nalane ea lelapa papaling ea papali ea chelete. J Nerv Ment Dis. 2003; 191: 124-126. [E fetotsoe]
93. DW e ntšo, Monahan PO, Temkit M, Shaw M. Phuputso ea lelapa ea papali ea papali ea methapo. Psychiatr Res. 2006; 141: 295-303. [E fetotsoe]
94. Slutske W, Eisen S, WR ea 'nete, et al. Kotsi e tloaelehileng ea lefutso bakeng sa papali ea papali ea chelete ea ho becha le ho itlopa joala ho banna. Arch Gen Psychiatry. 2000; 57: 666-673. [E fetotsoe]
95. Potenza MN, Steinberg MA, Skudlarski P, et al. Litlamorao tsa papali ea chelete ea ho becha le papali ea methapo ea mali: thuto ea maiketsetso e sebetsang. Arch Gen Psychiatry. 2003; 60: 828-836. [E fetotsoe]
96. Cunningham JA. Tšebeliso e nyane ea kalafo har'a ba bechang. Sebeletso sa Psychiatr. 2005; 56: 1024-1025. [E fetotsoe]
97. Brown RIF. Sebetsa sa ho becha Hoa tsebahala. Edington WR (ed) Lithuto tsa Papali ea Koloi: Lits'ebetso tsa Seboka sa Naha sa botšelela sa ho becha le ho ts'oara kotsi. Reno, NV: Bureau ea Khoebo le Lipatlisiso tsa Moruo, Univesithi ea Nevada, Reno 1985
98. Russo AM, Taber Jl, McCormick RA, Ramirez LF. Phuputso e entsoeng ea lenaneo la inpatient bakeng sa ba bechang. Hosp Comm Psychiatry. 1984; 35: 823-827. [E fetotsoe]
99. Taber Jl, McCormick RA, Russo AM, et al. Ho lateloa ha batsomi ba methapo ea methapo ka mor'a kalafo. Am J Psychiatry. 1987; 144: 757-761. [E fetotsoe]
100. Petry NM. Papali ea Pathological: Etiology Comorbidity, le Phekolo. Washington DC: Mokhatlo oa Amerika oa Psychological 2005
101. Ladouceur R, Sylvain C, Gosselin P. Lenaneo la ho itšehla thajana: thuto ea tlhahlobo ea bolelele. J ho bapala liithuti. 2007; 23: 85-94. [E fetotsoe]
102. Kim SW, Grant JE, Adson DE, Shin YC. Boithuto ba naltrexone bo sa boneng mahlo le boithuto ba placebo kalafong ea papali ea papali ea chelete. Biol Psychiatry. 2001; 49: 914-921. [E fetotsoe]
103. Grant JE, Potenza MN, Hollander E, et al. Lipatlisiso tse ngata tsa antio ea antio ea agio e sebelisang kalafo ea ho becha. Am J Psychiatry. 2006; 163: 303-312. [E fetotsoe]
104. DW e ntšo, Arndt S, Coryell WH, et al. Bupropion kalafo ea ho becha ea methapo ea methapo: thuto e sa reroang, e laoloang ea placebo, e bonolo. J Clinic Psychopharmacol. 2007; 27: 143-150. [E fetotsoe]
105. Grant JE, Potenza MN, Blanco C, et al. Paroxetine kalafo ea ho becha ha methapo ea methapo: teko e laoloang ka bongata e ikemetseng. Int Clin Psychopharmacol. 2003; 18: 243-249. [E fetotsoe]
106. Pallanti S, Rossi NB, Sood E, Hollander E. Nefazodone kalafo ea papali ea papali ea methapo: teko e lebelletsoeng e bulehileng ea lebitso. J Clinic Psychiatry. 2002; 63: 1034-1039. [E fetotsoe]
107. Zimmerman M, Breen RB, Posternak MA. Phuputso e bulehileng ea "citalopram" kalafong ea papali ea ho becha. J Clinic Psychiatry. 2002; 63: 44-48. [E fetotsoe]
108. Black DW, Shaw M, Allen J. Keketseho e pharalletseng ea carbamazepine kalafong ea papali ea papali ea methapo ea methapo: thuto e bulehileng. Prog Neurpsychopharmacol Biol. Psychiatry 2008; 32: 1191-1194. [E fetotsoe]
109. Black DW, Shaw M, Forbush KT, Allen J. Phuputso e bulehileng le ho ngola ea escitalopram kalafong ea papali ea ho becha. Clin Neuropharmacol. 2007; 30: 206-212. [E fetotsoe]
110. du Toit PL, van Kradenburg J, Niehaus D, Stein DJ. Ho bapisoa ha bakuli ba nang le mathata a ts'ebetso ea kelello a nang le ts'ebeliso e matla le e kantle ho comorbid e ka sebelisang puisano e hlophisitsoeng ea bongaka. Compr Psychiatry. 2001; 42: 291-300. [E fetotsoe]
111. Hantouche EG, Lancrenon S, Bouhassira M, et al. Pheta-tekolo ea ho se ts'oarehe ka har'a cohort ea bakuli ba 155 ba nang le bothateng bo bonahalang bo latelang: ho latela kamora likhoeli tsa 12. Encephale. 1997; 23: 83-90. [E fetotsoe]
112. Frost RO, Meagher BM, Ris mosa JH. Litšobotsi tse qobellang batho ho shebella lottery ea methapo le ho becha ka litekete. J Ho Ithuta Ho Becha. 2001; 17: 519. [E fetotsoe]
113. Forbush KT, Shaw MC, Graeber MA, et al. Litšobotsi tsa Neuropsychological le botho ba hae papaling ea papali ea chelete. Libaka tsa CNS. 2008; 13: 306-315. [E fetotsoe]
114. Black DW, Goldstein RB, Noyes R, Blum N. Boitšoaro bo hatellang le bokuli bo potelletseng (OCD): Ho hloka kamano pakeng tsa OCD, mathata a ho ja, le papali ea chelete. Compr Psychiatry. 1994; 35: 145-148. [E fetotsoe]
115. Bienvenu OJ, Samuels JF, Riddle MA, et al. Kamano ea bokuli bo likhathatso bo sa bonahaleng ba likoluoa ​​tse ka hlahang: litholoana tsa thuto ea lelapa. Biol Psychiatry. 2000; 48: 287-293. [E fetotsoe]
116. Goudriaan AE, Ossterlaan J, deBeurs E, van den Brink W. Papali ea papali ea chelete: Tlhahlobo e felletseng ea liphetho tsa biobehahlangual. Neurosci Biobehav Rev. 2004; 28: 123-141. [E fetotsoe]
117. Cavadini P, Riboldi G, Keller R, et al. Frontal lobe dysfunction ho bakuli ba ts'ebetso ea papali ea papali ea chelete. Biol Psychiatry. 2002; 51: 334-341. [E fetotsoe]
118. Menzies L, Chamberlain SR, Laird AR, et al. Ho kenyelletsa bopaki bo tsoang ho lithuto tsa neuroimaging le neuropsychological tsa mafu a hlokofatsang: mofuta oa orbitofronta-striatal o phetolotsoe. Neurosci Biobehav Rev. 2008: 525-549. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
119. Cunningham-Williams RM, Gattis MN, Dore PM, et al. Ho DSM-V: ho nahanisisa ka matšoao a mang a tlisoang ke ho khaotsa ho becha. Int J Methods Psychiatr Res. 2009; 18: 13-22. [E fetotsoe]
120. DW e ntšo, Gaffney GR. Ho hloka taolo-ho qobelloang ho sa hlokeng botsitso ho bana le ho bacha: liphetho tse ling tsa tlhahlobo e "kotsing e kholo". Libaka tsa CNS. 2008; 9 (suppl 14): 54-61. [E fetotsoe]