Mov Disord. 2011 Feb 1; 26 (2): 225-33. Doi: 10.1002 / mds.23480. Epub 2011 Jan 31.
Cilia R1, Cho SS, van Eimeren T, Marotta G, Siri C, Ko JH, Pellecchia G, Pezzoli G, Antonini A, Strafella AP.
inahaneloang
LITLHAHISO:
Papali ea chelete e ka hlaha ho lefu la Parkinson (PD) joalo ka bothata ba kalafo ea dopaminergic. Liphuputso tsa Neuroimaging li hlahisitse phetisetso e sa tloaelehang ea dopamine ka har'a sistimi ea moputso, empa liphetoho ho netweke ea neural e khethollang bakuli ba PD ba nang le papali ea chelete ha e so ka e batlisisoa.
LITLHAHISO:
Bakuli ba mashome a mararo a PD (15 ba nang le papali ea papali ea chelete ba sebelisang matekoane le taolo e tšoanang ea 15, meriana ea meriana) le lithuto tsa phetseng hantle tsa 15 li bile le lithuto tsa phepo e ntle ea bongoana. Botebo ba papali ea chelete ea papali ea chelete bo ile ba hlahlojoa ho sebelisoa Score ea South Oaks ea Papali ea chelete. Ho ile ha sebelisoa tlhahlobo ea Covariance ho supa libaka tsa boko tseo mesebetsi ea tsona e amanang le ho becha ho teba. Likarolo tsena li ile tsa sebelisoa e le bophahamo ba sekhahla sa ho tseba libaka tse hokahantsoeng ka tšebeliso ea tlhahlobo ea bohlale ba voxel. Mohlala oa tsela o ile oa hlalosoa ka mokhoa o hlakileng oa tšebeliso ea khokahano ka har'a sebopeho sa Structural Equation Modeling
LIKOTSO:
Ho tsitsa ka mokhoa oa ho becha ho ne ho amana le ho se sebetse hantle ha khokahano ea boko e kentsoeng tšebetsong ea ho nka qeto, ts'ebetso ea kotsi, le tšitiso ea karabo, ho kenyelletsa cortex ea ventrolateral preortal, anterior (ACC) le posterior cingates cortex, cortex ea medial prewardal, insula le striatum. Barekisi ba PD ba bonts'itse khokahano lipakeng tsa ACC le striatum, athe ts'ebelisano ena e ne e le matla ho lihlopha tse peli tsa taolo.
TŠOHLOOHO:
ACC-striatal disconnection e kanna ea baka tšenyo e itseng ea boitšoaro bo fetohang kamora liphetho tse mpe, mohlomong e hlalosa hore na ke hobaneng ha batsomi ba PD ba sebelisa ho tiisetsa liketsong tse kotsi le ha ba ipeha kotsing.
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