Psychopharmacology (Berl). 2015 Oct 28.
Sustkova-Fiserova M1, Jerabek P.2, Lefu la Havlickova T.2, Syslova K3, Kacer P3.
inahaneloang
TLHOKOMELISO LE LITLHAKISO:
Ntle le dopamine, li-endocannabinoids ho nahanoa hore li nka karolo mekhoeng ea moputso oa neural ea opioids. Palo ea lithuto tsa morao-rao e bonts'a ho nka karolo ea bohlokoa ea ghrelin litlamorao tsa lithethefatsi tse ling. Liphetho tsa rona tse fetileng li bonts'itse hore ghrelin e nka karolo liphetoho tse tlisoang ke morphine tsamaisong ea mesolimbic dopaminergic e amanang le ts'ebetso ea moputso. Morero oa thuto e teng hona joale e ne e le ho hlahloba hore na "hormone" ea "agricag "receptor (GHS-R1A) e hlohlelletsa motho ea nang le tšusumetso ea morphine e hlahisang anandamide (N-arachidonoylethanolamine, AEA) le 2959-arachidonoylglycerol (2) li-nucleus accumbens shell (NACSh).
LITLHAHISO:
Re sebelisitse ho vivo microdialysis ho fumana liphetoho maemong a AEA le 2-AG ho NACSh ho likhoto tse latelang (i) lethal dose ea morphine (5, 10 mg / kg sc) le pele ho kalafo ea JMV2959 (3, 6 mg / kg) ip) kapa (ii) tekanyetso ea phephetso ea morphine (5 mg / kg sc) e nang le pele le ntle le JMV2959 (3, 6 mg / kg ip), e tsamaisoang nakong ea ho ithiba ho latela litekanyetso tse phetoang tsa morphine (matsatsi a 5, 10-40 mg / kg ). Tšebelisano-'moho ea ghrelin (40 ug / kg ip) e ne e sebelisetsoa ho netefatsa mekhoa ea ho kenella ha ghrelin.
LIKOTSO:
Refreatment e nang le JMV2959 haholo le litekanyetso tse tsamaisanang le li-morphine tse itšetlehileng ka moriana li ntse li eketseha ho NACSh mefuteng eo ea pele le e telele, e bakang ho fokotseha hoa bohlokoa hoa AEA. JMV2959 e matlafalitsoeng haholo ho hlobaela ha morphine-ikiwa e fokotseha ka sekhahla sa li-accumbens tsa 2-AG le pheko ea morphine e hlahisoang ke 2-AG e fokotseha. Prizetso ea JMV2959 e fokolitse haholo tšebeliso ea boitšoaro bo tšoanang ba morphine. Liphetho tsa pele tsa JMV2959 li ile tsa felisoa ka tsamaiso ea tšebelisano ea ghrelin.
CONCLUSIONS:
Liphetho tsa rona li bonts'a ho nka karolo ho hoholo ha matšoao a ghrelin ho liphetoho tsa morocinabone tsa endocannabinoid ho NACSh.
LINKOTSO:
2-Arachidonoylglycerol; Ho hlobaela; Anandamide; Phephetso nakong ea bootsoa; Endocannabinoids; Ghrelin; Microdialysis; Morphine; Sistimi ea moputso ea Neural; Li-shell tsa nyutlelie; Boitšoaro bo hlephileng
PMID: 26507196
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