Ke hobane'ng ha mehopolo ea hau e le mpe ha u lapetse? (2016)

Ben Locwin | Hlakola 17, 2016 | Morero oa tsebo ea ho bala le ho ngola

Bohle re tseba molao oa ho khetha ho ea mabenkeleng: Etsa eseng e etse ha o lapile; Tlala e na le mokhoa o bolotsana oa ho etsa hore u kenye lintho ka kariking ea hau ea mabenkele eo ho seng joalo e ka be e sa ka ea e etsa moo.

Mona ke potso e 'ngoe mabapi le hore na mekhoa ea tlala e ama joang ts'ebetso ea hau: Ha u lapile, na o kile oa ikutloa eka o na le nako e thata ea ho hopola lintho? Ho na le tlhaloso e bonolo ea likokoana-hloko bakeng sa sena: Ha 'mele oa hau o itokafatsa bakeng sa ho ja, ha o batle ho qeta matla a sa hlokahaleng mesebetsing e matla joaloka ho nahana.

Empa tlala ha e le hantle e na le kamano e poteletseng haholo ea ho nahana ka boyona, kapa ka mokhoa o hlakileng haholoanyane, ka memori. E 'ngoe ea lihormone tsa tlala tse bakang Takatso ea rona ea lijo le metabolism li bitsoa 'ghrelin,' mme ke hormone e tsoang ka mpeng. Ha u nka nako e telele haholo u sa je, 'mele oa hau o hlahisa ghrelin e ngata ho matlafatsa pheello ea matla a lijo, mme kamora hore o je, ghrelin e bontša tsamaiso ea methapo e kholo boteng ba limatlafatsi tšilong ea lijo. Ntle le ho eketsa takatso ea lijo, ghrelin e tsejoa hape e amahanngoa le ho laola metabolism, ho ruruha ho matlafatsang, ho eketsa ts'ebetso ea pelo, le ho eketsa kholo ea lihormone, kholo e tšoanang le kholo ea insulin.

Ho latellana ha liphatsa tsa lefutso ho hlahisitse mefuta e 12 (single-nucleotide polymorphisms) ka har'a lefutso le hlahisang ghrelin, le mefuta e 8 e tsebahalang ea lefutso bakeng sa ghrelin receptor (protheine e teng seleng e shebiloeng e lumellang ghrelin ho 'ema' le ho sebetsa litlamorao tsa eona. ). E nkuoa e le lethathamo la bafani ba metabolic (lintho tse thusang ho laola metabolism ea rona), ho na le mekhatlo lipakeng tsa liphatsa tsa ghrelin le receptor ea eona ka boits'oaro ba ho ja, ho boloka matla le ho hanyetsa insulin. Boithuto ba batho ba nang le liphatsa tsa lefutso ho ghrelin le receptor ea bona li bontša phapang mokhoeng oa ho ja le oa insulin. Sena sea utloahala, kaha ghrelin e ikhethile joaloka lihormone tse nang le bokhoni ba eona ba ho kenya letsoho ho matlafatseng matla ka ho susumetsa ho ja le ho fokotsa metabolism ea caloric.

Empa ho na le tse ling hape paleng ea ghrelin, hape: Ho bile joalo e amanang ka ho eketsa boleng ba thabo le lijo tse nang le moputso tse tlisoang ke ho ja. Sena se bonahala e le ntho e mpe haholo joalo ka karolo ea seo neurotransmitter dopamine e ikarabellang ho: Ho lelekisa moputso.

E le hore li-hormone leha e le life li sebetse, e hloka li-receptor hore li tsose. Ho na le li-receptor tsa ghrelin (GHSR1a) bokong, empa karolo ea bona ha se ea litlamorao tsa metabolic, empa, ho fapana le hoo, bafuputsi ba bang ba pheha khang ea hore ba khona ho hopola lintho.

Ho makatsang ke hore e bile teng e hlokometse ke bafuputsi hore li-receptor tsa ghrelin li sebetsa tumellanong le li-receptor tsa dopamine ho lumella ts'ebetso e nepahetseng ea hippocampus ho kopantseng memori, hammoho le ntlafatso ea synaptic le polasetiki ea synaptic. Mohlomong u utloile 'neuroplasticity'e boletsoe lipapatsong bakeng sa likarolo tse fapaneng tsa software ea ho koetlisa bokong. Ke lentsoe feela le bolelang bokhoni ba kelello ba ho lula bo ikamahanya le mathata a macha le a fapaneng a kelello. E etsa sena ka ho hola li-neuron le ho holisa khokahano ea li-neuronal.

Mechini e reriloeng e sebetsa tjena: Mokelikeli oa ghrelin (ntle le ghrelin e teng) o fetola sebopeho sa receptor ea dopamine mme o fetola tsela eo e tšoaeang ka eona bokong. Hippocampus e hlahisitse liphatsa tsa lefutso (ke hore, liprotheine tseo ba li ngolang li hlahisoa ka nako e le ngoe) bakeng sa li-ghrelin receptors 'me dopamine receptors (DRD1), mohlomong hobane bobeli ba bohlokoa. Neng bafuputsi e thibetse receptor ea ghrelin hore e se ke ea khona ho sebelisana le dopamine receptor, tlhahiso ea memori e ile ea thibeloa.
Ho na le kamano e matla le mathata a itseng a methapo ea kutlo le tahlehelo ea methapo ea kutlo. Tahlehelo ena e ka fokotsoa ke kalafo e thehiloeng ho ghrelin, hobane methapo ea pelo e khothaletsa kholo le ho ata ha methapo ea kutlo - mme ka hona e khutlise tse ling tsa lisosa tsa ts'oaetso ea methapo ea kutlo le tahlehelo (joalo ka Alzheimer's, Parkinson's, le stroke). Haeba mokamo oa ghrelin o ka hlohlelletsoa ho hlophisa tšebetso ea mokelikeli oa dopamine, ho boetse ho na le monyetla o moholo oa ho matlafatsa kapa ho thibela ts'ebetso ea dopamine ka litlamorao tse fokolang ho feta mekhoa ea kalafo e seng e ntse e le teng.

Ben Locwin, Ph.D., MBA, MS ke mothusi oa Morero oa Palo ea ho Bala le ho Ngola 'me ke sengoli sa lingoloa tse fapaneng tsa mahlale tsa libuka le limakasine. Ke setsebi se ikopantseng le American Association of Pharmaceutical Scientists (AAPS), setho sa komiti ho American Statistical Association, hape ke moeletsi bakeng sa liindasteri tse ngata ho kenyeletsoa mahlale a thuto ea bophelo, meriana, kelello le thuto. Mo latele ho @BenLocwin.

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