Corticostriatal Afferents E-ba le Boikarabello ho Meriana ea Psychostimulant le Li-Associated Stimuli (2015)

Neuropsychopharmacology. 2015 Aug 20. Doi: 10.1038 / npp.2015.253.

Kerstetter KA1, Wunsch AM1,2, Nakata KG1,2, Donckels E1, Neumaier JF2,3,4, Ferguson SM1,2,3.

inahaneloang

Medial prefrontal cortex (mPFC) le nucleus accumbens (NAc) ka bobeli ke likarolo tsa bohlokoa tsa cortico-basal ganglia-thalamic circry e laolang boitšoaro bo amanang le bokhoba. Leha ho le joalo, karolo ea litlatsetso tse tsoang ho mPFC ho ea ho NAc ka boits'oaro bona ha e hlake.

Ho sebetsana le sena, re sebelisitse mokhoa oa veter-veombinase o itšetlehileng ka vaerase ho hlahisa Gi / oLi-DREADD tse hlahisitsoeng (Moqapi Receptors O Ikhethisitsoe Haholo-holo ke Lithethefatsi tsa Moqapi) ka MPFC neurons e kenella ho NAc mme e hlahloba litlamorao tsa ho kenyelletsa tšebetso ea methapo ena ho kenngoeng ha sensorization ea amphetamine le ho tseng lithethefatsi le ho tseng lithethefatsi nakong ea boits'oaro ba koae.

Ho makatsang ke hore ho fokotsa ts'ebetso ea kopanelo ea mPFC ho NAc feela e fokotsang maikutlo a sensomotor ka nakoana mme ha ho na phello ea ho sebelisa lithethefatsi nakong ea boits'oaro ba koae.

Leha ho le joalo, ho thibela ts'ebetso ea kamano ea corticostriatal nakong ea maikutlo a morao-rao ho ntlafalitsoeng ho arabela.

Ntle le moo, ho qhekella hona nakong ea boitaolo ba lithethefatsi ho felletse ka ho fokotseha ha maemo ka potlako le ho eketseha ha karabo nakong ea ts'usumetso e matla ea lithethefatsi-e leng phello e neng e tloaelehile ka ho thibela mekhatlo ena e amanang le corticostriatal hang pele ho sehlooho sa lithethefatsi.

Liphetho tsena li fana ka maikutlo a hore ho fokotsa taolo ea cortical holim'a NAc nakong ea ts'ebetso ea lithethefatsi ho ka lebisa ho liphetoho tsa nako e telele ho bokhoni ba lithethefatsi le tšusumetso e amanang le ho khanna boitšoaro