ScienceDaily (Phupu ea 25, 2012) - Ho phahamisa maemo a dopamine ea neurotransmitter karolong e ka pele ea cortex ea boko ho fokotsehile ho kenella ho batho ba baholo ba phetseng hantle, phuputsong e entsoeng ke bafuputsi Ernest Gallo Clinic le Center Center ea Phuputso Univesithing ea California, San Francisco.
"Ho ba le takatso e matla ke sesosa sa kotsi ea ho lemalla lintho tse ngata, mme ho bile le tlhahiso ea hore batho ba nang le maemo a tlase a dopamine karolong e ka pele ea cortex ba tloaetse ho ba le tšusumetso e matla," ho boletse mongoli ea etelletseng pele Andrew Kayser, PhD, mofuputsi oa Gallo le mothusi oa moprofesa ea methapo ea pelo ho UCSF. "Re ne re batla ho bona hore na re ka fokotsa ho se tsotelle ka ho hlahisa dopamine, 'me ho bonahala eka re ka khona."
Phuputso ena e phatlalalitsoe ka Phupu 4 ho Journal of Neuroscience.
Phuputsong e laoloang habobebe, e laoloang ke placebo, barupeluoa ba baholo ba 23 ba ile ba fuoa tolcapone, moriana o amohetsoeng ke Tsamaiso ea Lijo le Lithethefatsi (FDA) o thibelang enzyme e nyenyefatsang ea dopamine, kapa placebo. Eaba bafuputsi ba fa bankakarolo mosebetsi o lekanyang ho se ts'oenyehe, ba ba kopa ho etsa khetho ea boikaketsi lipakeng tsa ho amohela chelete e nyane hanghang ("e nyane kapele") kapa e kholoanyane hamorao ("kholoanyane hamorao"). Morupeluoa e mong le e mong o ile a lekoa habeli, hang ka tolcapone mme hang ka placebo.
Barupeluoa - haholo-holo ba neng ba e-na le tšekamelo ea mantlha mothating oa mantlha - ba ne ba le monyetla oa ho khetha khetho e sa reng letho ea "kholo hamorao" kamora ho nka tolcapone ho feta kamoo ba neng ba le ka mor'a ho nka placebo.
Pono ea maqhubu a matla a ts'oaro e sebelisitsoeng ha barupeluoa ba ntse ba ngola tlhahlobo e netefalitse hore libaka tsa "cortex" tse ka pele tse amanang le ho etsa liqeto li ne li le mafolofolo ho feta tolcapone ho feta boteng ba placebo.
Kayser o itse: "Ho latela tsebo ea rona, ena ke thuto ea pele ea ho sebelisa tolcapone ho batla tšusumetso ho se ts'oenyeheng."
Boithuto bona bo ne bo sa etsetsoa ho fuputsa mabaka a entseng hore dopamine e fokotsehang e amanang le ho se tsitse. Leha ho le joalo, ho hlalositse Kayser, bo-ramahlale ba lumela hore ho susumetsoa ho amana le ho se leka-lekane ha dopamine pakeng tsa cortex ea pele, e tsamaisang mesebetsi e metle joalo ka taolo ea kelello le ho itaola, le striatum, eo ho nahanoang hore e kenya letsoho ho rala le ho fetoloa ha boits'oaro bo tloaetseng ho feta.
"Boholo, haeba e se bohle, lithethefatsi tsa tlhekefetso, joalo ka cocaine le amphetamine, ka kotloloho kapa ka ho sa tobang li kenyelletsa sistimi ea dopamine, "ho boletse Kayser. Ba tloaetse ho eketsa dopamine mokokotlong, e leng se ka 'nang sa putsa boitšoaro bo potlakileng. Ka mokhoa o bonolo haholo, striatum e re 'tsamaea,' mme cortex e ka pele e re 'emisa.' Haeba u noa k'hok'heine, u eketsa letšoao la 'go', 'me letšoao la' stop 'ha lea lekana ho le loants'a. ”
Kayser le sehlopha sa hae sa lipatlisiso ba rera thuto e latelang ea litlamorao tsa tolcapone mokhoeng oa ho noa. "Hang ha re bona hore na batho ba noang ba ka mamella meriana ena ka mokhoa o sireletsehileng, re tla bona hore na e na le phello efe ho noa ha bona ha ba ntse ba e noa," ho boletse Kayser.
Tolcapone e amoheloa e le moriana oa lefu la Parkinson, moo khaello e sa foleng ea dopamine e sitisang motsamao.
Bangoli ba pampiri ena ke Daicia C. Allen, BS, Ana Navarro-Cebrian, PhD, Jennifer M. Mitchell, PhD le mongoli ea phahameng Howard L. Fields, MD, PhD, oa Gallo Center le UCSF.
Boithuto bona bo tšehelitsoe ke chelete e tsoang Setsing sa Wheeler sa Neurobiology of Addiction, US Army Telemedicine and Advanced Technology Research Center, Alcoholic Beverage Medical Research Foundation / The Foundation for Alcohol Research le Naha ea California.
Sengoloa sa Sengoloa:
Andrew S. Kayser, Daicia C. Allen, Ana Navarro-Cebrian, Jennifer M. Mitchell, le Howard L. Fields. Dopamine, Khokahano ea Corticostriatal, le Khetho ea Intertemporal. Koranta ea Neuroscience, 4 Julayi 2012, 32 (27): 9402-9409 DOI: 10.1523 / JNEUROSCI.1180-12.2012
PHAPUSI EA HO BALA
Dopamine, khokahano ea corticostriatal, le khetho ea mahareng.
J Neurosci. 2012 Jul 4; 32 (27): 9402-9.
Kayser AS, Allen DC, Navarro-Cebrian A, Mitchell JM, Fields HL.
mohloli o moholo
Lefapha la Neurology, Univesithi ea California, San Francisco, San Francisco, California 94143, Ernest Gallo Clinic le Setsi sa Patlisiso, Emeryville, California 94608, le Lefapha la Neurology, Litaba tsa Veterans Leboea la Bophelo bo Botle, Martinez, California 94553.
inahaneloang
Liqeto tse thehiloeng boleng li ntlafatsa litholoana tsa boitšoaro. Hobane meputso e liehang e theotsoe, tloaelo ea ho khetha khetho e nyane, kapele e ka lebisa khetho e nyane. Phokotseho e tlase ea meputso e liehang (ho se ts'oanelehe) e tšoaea lithuto tse nang le tšenyo ea lobe ea pele le mathata a boitšoaro bo kenyeletsang tlhekefetso ea lithethefatsi. Ka mokhoa o ts'oanang, lithuto tsa liphoofolo le bopaki bo sa tobang ho batho li fana ka maikutlo a hore dopamine e ka tlase ea cortex e ka pele e thusa ho theola sekhahla ka ho fokolisa mosebetsi oa corticostriatal. Ho etsa tlhahlobo ena ka kotloloho, re ile ra etsa lipatlisiso tse sa laoloeng, tse foufetseng, tse hanyetsanang le sebaka seo re tsamaisitseng ts'ebetso ea kelello penateant catechol-O-methyltransferase inhibitor tolcapone kapa placebo ho lithuto tse phetseng hantle tse etsang mosebetsi oa ho theola. Tolcapone e eketsehile haholo khetho ea meputso e liehang ea chelete, 'me keketseho ena ea tolcapone e kenyellelitsoeng e kenyellelitsoeng ke mosebetsi o mongata oa BOLD ho ts'ebetso ea ventral putamen le anterior insula. Tolcapone e boetse e fetotse khokahanyo ea corticostriatal: ka ho khetheha, ka ho etsa hore ho fokotsehe ha tumellano pakeng tsa ventral putamen le cgenex ea cortex ea pele. Liphetho tsena li bonts'a hore ho phahamisa maemo a cortical dopamine ho hlahisa khetho e sa tsitsang ka ho fetola ts'ebetso ea corticostriatal.
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