Prog Neuropsychopharmacol Biol Psychiatry. 2020 Apr 20; 99: 109864. Doi: 10.1016 / j.pnpbp.2020.109864. Epub 2020 Jan 15.
Mascia P1, Wang Q1, Brown J1, Nesbitt KM2, Kennethy RT3, Vezina P4.
inahaneloang
Haufinyane tjena re tlalehetse hore li-nucleus accumbens (NAcc) dopamine (DA) li latela ho hloka botsitso nakong ea ts'ebetso e arabelang sa non-caloric saccharin. Re boetse re bonts'itse hore nako le nako ho pepesetsoa ts'ebetso ena e sa tsitsang, joalo ka ho pepesetsoa lithethefatsi tsa tlhekefetso, ho lebisa tlhokomelong ea litlamorao le lipehelo tsa NAcc DA tsa amphetamine mme li khothaletsa boits'ireletso ba kamoso ba moriana. Mona re lekola liphumano tsena mmoho le ba bang ba bonts'ang hore NAcc glutamate signaling le eona e anngoe ke ho se ts'oenyehe. Mefuta e meng ea glutamate sebakeng sena e boetse e latela mokhoa o sa tsitsinyeheng oa ho etsa pompo bakeng sa saccharin lenaneong le ntseng le eketseha la matlafatso le amahanngoa le phapang e tsoelang pele pakeng tsa ts'ebetso ea mosebeletsi le ea lefang. Ho feta moo, karabelo ea boits'oaro bo khahlisang ba ho arabela le bakeng sa amphetamine kamora ho pepeseha ho se tsitsitseng e tsamaea le maemo a eketsehang a Ca2+/ proteinodase-based protein protein kinase II (CaMKII) le phofo ea protheine kinase C (PKC) hammoho le maemo a liprotheine a fetotsoeng a transcript factor ∆FosB (e eketsehile) le glutamate transporter 1 (GLT1; fokotsehile) ho li-tiske tsa NAcc. Haholo, phosphorylation ea CaMKII le PKC e laola ts'ebetso ea ho ts'oaroa ha AMPA le ho sebetsa sebakeng sena sa marang-rang, e phahamisoa ka mor'a ho pepeseha ha psychostimulant, mme ho hlokahala bakeng sa tlhahiso ea ts'ebeliso e matla ea lithethefatsi. Keketseho ea BFosB e ntseng e eketseha le litekanyetso tse fokotsehileng tsa GLT1 li bonoa ka mor'a ho pepesetsoa psychostimulant, li amahanngoa le ho eketseha ha lithethefatsi le ho li batla, 'me li tsejoa ho fetolela li-receptor tsa AMPA le maemo a extracellular glutamate ka tatellano. Liphetoho tsena phetisong ea glutamate mmoho le tse bonoang le DA khafetsa ho pepeseha nako le nako ho se tsitsitseng ho ts'oana le tse hlahisoang ke ho pepesehela lithethefatsi tse hlekefelitsoeng. Ka kopanelo, ba supa ho haptjoa ha litsela tsa bobeli tsa DA le glutamate signature ho NAcc litlamorao tsa lithethefatsi le boits'oaro. Joalokaha ho hloka botsitso e le karolo ea mantlha ea lipapali, liphetho tsena li na le bohlokoa bo itseng bakeng sa mathata a papali ea papali ea chelete a tsejoang ka ho bonts'a ts'ebeliso e mpe ea lithethefatsi.
LINKOTSO: Amphetamine; Dopamine; Ho becha; Glutamate; Sensitization; Ho hloka botsitso
PMID: 31952958
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