Ho bapisoa le Matšoao a Maiketsetso le Mefuta ea Serum ea Li-Neurotransmitters ea Shanghai Bacha ba nang le ntle le Inthaneteng Mathata a Mathata: Tlhahlobo ea Tlhahlobo ea Tlhahlobo (2013)

PLoS One. 2013 May 3; 8 (5): e63089. doi: 10.1371 / journal.pone.0063089.

Zhang HX, Jiang WQ, Lin ZG, Du YS, Bontša A.

mohloli o moholo

Lefapha la Keletso Bongaka, Sepetlele sa Zhongshan, Univesithi ea Fudan, Shanghai, China.

inahaneloang

Background

Bothata ba bokhoba ba ts'ebeliso ea inthanete (IAD) joale bo se bo amoheloa lefatšeng ka bophara mme bo tsejoa bo amana le ho senyeha ha barutehi le sechaba. Ho fihla joale, re tseba hanyane ka likarolo tsa mantlha tse amanang. Phuputso ena e etselitsoe ho bokella sehlopha se hlalositsoeng ka hloko sa bacha ba nang le IAD le sehlopha sa lilemo tse lekanang le ba batona le ba batšehali. Re bile le maikutlo a hore bacha ba nang le IAD ba tla ba le litheko tse phahameng tsa boits'oaro bo ipolelang le matšoao a sithabetsang, ba fetotse maemo a dopamine ea mali, norepinephrine le serotonin. Ntle le moo, re ile ra kopanya lihora tse sebelisitsoeng marang-rang li amana le ho teba ha khatello ea maikutlo le matšoenyeho hara bacha bana ba nang le IAD.

Methodology / Ho Fumana Haholo

Ho ile ha etsoa thuto ea sefapano ea bacha ba 20 ba fihletseng litekanyetso tsa Beard tsa IAD le 15 tse ntseng li eketseha tsa bocha (sehlopha sa bapiso). Bohle ba neng ba nkile karolo ba ile ba phethela Sekala sa Boemo ba ho Ikhaola ba Boithati (SDS), Boitšoaro ba Boithati ba Boithati (SAS), le Screen bakeng sa Matšoenyeho a amanang le khatello ea maikutlo a bana (SCARED). Chelete ea mali ea dopamine, serotonin le norepinephrine li ile tsa lekoa. Lebelo le bolelang la norepinephrine le ne le le tlaase sehlopheng sa IAD ho feta ho batho ba atisang ho ntshetsa pele, ha maemo a dopamine le serotonin a sa fapane. Lintlha tsa matšoao a SDS, SAS le SCARED li ile tsa eketseha ho bacha le IAD. Tlhahlobo ea khatello ea lits'ebeletso e senola hore palo e phahameng ea SAS le karolo e tlase ea norepinephrine e ikemiselitse ho ba litho tsa sehlopha sa IAD. Ho ne ho se na kamano e kholo pakeng tsa lihora tse sebelisoang Inthaneteng le tse ngata tsa SAS / SDS sehlopheng sa IAD.

Sephetho / Bohlokoa

Ho tšoenyeha ho eketsehileng ha tlaleho ea boits'oaro le norepinephrine e nyane e ikemetseng e amahanngoa ka boithatelo le IAD.

Tlhaloso: Zhang HX, Jiang WQ, Lin ZG, Du YS, Vance A (2013) Ho bapisoa ha Matšoao a Psychological le li-Level tsa Serum tsa Neurotransmitters ho Shanghai Adolescents e nang le ntle le Tlatsetso ea Tlatsetso ea Inthanete: Thutong ea Taolo ea Nyeoe. PloS ONE 8 (5): e63089. Doi: 10.1371 / journal.pone.0063089

mohlophisi: Jerson Laks, Univesithi ea Federal ea Rio de Janeiro, Brazil

Re amohetse: December 31, 2012; E amohetse: Ka March 27, 2013; E phatlalalitsoe: E se eka 3, 2013

Copyright: © 2013 Zhang et al. Ena ke sengolo se bulehileng se fihletsoeng tlasa tumellano ea Lichelete ea Tlhahiso ea Creative Commons Attribution, e lumellang tšebeliso e sa thibeloang, phetiso, le tlhahiso hape ka mofuta o mong le o mong, ha feela moqapi oa mantlha le mohloli ba ngoliloe.

Lithuso: Mosebetsi ona o tšehelitsoe ke lithuso tse tsoang ho "11th ea lilemo tse hlano" ea naha e ts'ehetsang merero ea mahlale le mahlale a China, karolo ea (2007BAI17B03). Letlole le ne le sena karolo moqopolong oa ho ithuta, ho bokella data le ho hlahlobisisa, qeto ea ho phatlalatsa, kapa ho hlophisa sengoloa. Sebaka sa marang-rang sa Lekala la Mahlale le Theknoloji ea Rephabliki ea People of China se ka tsela e latelang: http://www.most.gov.cn/.

Lithahasello tse tsitsitseng: Bangoli ba boletse hore ho na le lithahasello tsa tlhōlisano tse teng.

Selelekela

Bothata ba bokhoba ba ts'ebeliso ea Inthanete (IAD) bo hlahile ka lebaka la ts'ebetso e atileng ea inthanete. [1]-[3]. Ho senyeha hoa ts'ebetso lithutong tsa thuto, tsa sechaba, tsa malapa le tsa mosebetsi li ngotsoe ebile li hokahane le IAD [2], [4]. Ho na le lintlha tse 'maloa tse ntlafalitsoeng joalo ka lilemo tse nyane tsa ts'ebeliso ea marang-rang, matšoenyeho a eketsehang le matšoao a nyahamisang le / kapa mathata [5]-[7]: lintlha tse phahameng ho Beck Depression Inventory (BDI) [6] kapa Center for Epidemiological Study Depression Scale (CES-D) [7] li amanang le IAD. Ho feta moo, ho na le mathata a mangata a ho sithabela maikutlo maikutlong ho Buka ea Matla le Mathata, ho tšoenyeha ho hoholo le maikutlo a eketsehileng a ho ipolaea ho tlalehiloe ho bacha ba nang le IAD [8]-[10].

Hajoale, lintlha tsa mantlha tsa biolo tse amanang le IAD li lula li sa hlaka [6]. Llintlha tsa ikely li kenyelletsa ho se leka-lekane ha maemo a sebetsang a dopamine (DA), serotonin (5-HT), le / kapa norepinephrine (NE), e amanang le ho qaleha ha maikutlo a ho ferekana le khatello ea maikutlo joalo ka ho se leka-lekane ha serotonin le norepinephrine neuronal nchafatso ea axon [11]-[15]. Ho feta moo, sekhahla sa phallo ea ts'ebetso ea serotonin e fokotsehileng se hokahane le pherekano e kholo ea khatello ea maikutlo mme e ka ba le phello ho IAD [16]. Re bile le maikutlo a hore bacha ba nang le IAD ba tla ba le litheko tse phahameng tsa ho itlhalosa le matšoao a nyahamisang le maemo a fetotsoeng a dopamine ea mali, norepinephrine le serotonin.

Tonioni et al. [17] re khethile kamano lipakeng tsa lihora tse sebelisitsoeng marang-rang le khatello ea maikutlo / maemo a ho tšoenyeha, re kopantseng lihora tse sebelisitsoeng marang-rang li kanna tsa amahanngoa le lintlha tse ngata tsa SAS / SDS har'a bacha ba nang le IAD.

Lisebelisoa le mekhoa

barupeluoa ba

Baithuti ba lilemong tsa bocha ba 20 ba nang le IAD, ho ea ka litekanyetso tsa Beard [17], ba hloaetsoa ho tsoa lefapheng la tsa bophelo bo botle la Shanghai Mental Health Center ho la Shanghai Jiao Tong University School of Medicine ho tloha ka Phupu 2008 ho fihlela ka Pherekhong 2010. Baithuti bana ba ne ba qeta lihora tse ka bang 33.8 (16.8) ka beke ba sebelisa inthanete marang-rang. They kaofela ba ne ba phathahane ka marang-rang (ba nahana ka tšebetso e fetileng ea inthanete kapa ba lebelletse lenaneo la bona le latelang la inthanete); e hloka ho sebelisa Marang-rang bakeng sa nako e eketsehileng ea ho lekana; ba sa khone ho laola, ho fokotsa le ho emisa tšebeliso ea bona ea inthanete; ho phomola, ho ts'oareha, ho tepella maikutlo le / kapa ho teneha ha ts'ebeliso ea bona ea Marang-rang e khaotsoe kapa e emisoa; le ho lula marang-rang nako e telele ho feta kamoo ho neng ho reretsoe pele. ken ho feta moo, ba ne ba bontšitse bonyane letšoao le le latelang la tse tharo: ba beile kotsing ea ho lahleheloa ke kamano ea bohlokoa, mosebetsi, thuto kapa monyetla oa mosebetsi ka lebaka la ts'ebeliso ea bona ea inthanete; leshano ho litho tsa lelapa kapa ba bang ho pata boholo ba tšebeliso ea bona ea inthanete; le / kapa o sebelisitse marang-rang e le mokhoa oa ho baleha mathata kapa oa ho imolla letsoalo la dysphoric. Ba ne ba nkuoa ba sa sebetse hantle haeba ba ne ba ithutile ka boomo, ba bonahetse ho hana sekolo le / kapa ho lauoa ke ba boholong (matichere le / kapa batsoali) ka lebaka la tšebeliso e mpe ea inthanete. Baithuti ba ne ba sa qheleloe ka thoko haeba ba ne ba na le bopaki ba bothata bofe kapa bofe ba bongaka ba "comorbid" boloetse ba kelello bo neng bo le teng pele / kapa ba ne ba sebelisa meriana efe kapa efe ea kelello.

Ka tloaelo baithaopi ba lilemong tsa bocha ba ntseng ba hola ba lilemong tsa bocha le ba bong bo tšoanang, ba tsoang tikolohong e le 'ngoe ea sechaba se kopaneng (sekolo se mahareng ho la Shanghai) ntle le ts'ebetso ea bongaka kapa ea mafu a kelello, tšebeliso ea joala le / kapa ts'ebeliso ea lithethefatsi li ile tsa hloaea e le karolo ea karolo ea taolo e phetseng hantle. Ho fumanoe tumello e fumanoeng ho tsoa ho bohle ba nkang karolo le bahlokomeli ba bona ba molao. Ho ne ho na le bashanyana ba 18 le banana ba 2 (ho bolela lilemo tsa 16.8 ± lilemo tsa 1.8) sehlopheng sa IAD le bashanyana ba 13 le banana ba 2 (ho bolela lilemo tsa 18.1 ± 2.7 lilemo) sehlopheng se ntseng se hola ka tloaelo.

Boitšoaro ba Melao

Boithuto bona e ne e le karolo ea lipatlisiso tse kholo tse neng li shebane le mathata a boitšoaro ba bacha. Karolo ena e amohetsoe ke Setsi sa Boto ea Tlhahlobo ea Mekhatlo ea Shanghai Mental Health. Boithuto bona bo ne bo etsoa Shanghai feela, eseng ka ntle ho China. Barupeluoa le bahlokomeli ba bona ba molao ba ile Setsing sa Bophelo sa Mantlha sa Shanghai ho Shanghai Jiao Tong University School of Medicine bakeng sa seboka sa lihora tse peli ka likhefu ha ho hlokahala. Ho ile ha fumanoa tumello e ngotsoeng nakong e fetileng, ka mor'a hore liteko li hlalosoe hantle ho barupeluoa le bahlokomeli ba bona ba molao.

Mehato

Potso ea Beard's Diagnostic Potso ea ho lemalla joala Inthanete [18]: Lintho tsa 8 ka kakaretso, ka tekanyo ea likhetho tsa dichotomous (E / Che). IAD e fumanoa ha lintho tsohle tsa 5 tsa pele li kopana le bonyane e le 'ngoe ea lintho tse latelang tsa 3 tse kopaneng.

Boemo ba Boemo ba ho Itepella Maikutlo (SDS) [19]: Lintho tsa 20 tse nang le likalo tse Likert tsa lintlha tse 'ne. Pholo e phahameng e supa matšoao a nyahamisang le ho feta. Ho nepahala le ho ts'epahala ho lekane ho People's Republic of China.

Boemo ba ho Iketsetsa Matšoenyeho (SAS) [20]: Lintho tsa 20 tse nang le likalo tse Likert tsa lintlha tse 'ne. Pholo e phahameng e supa matšoao a ho tšoenyeha ho hoholo. Ho nepahala le ho ts'epahala ho lekane ho People's Republic of China.

Screen bakeng sa Matšoenyeho a amanang le maikutlo a bana (SCARED) [21], [22]: Lintho tsa 41 kaofela ka thekiso ea Likert ea lintlha tse tharo e ts'ehetsang lintlha tse hlano: 'somatic / panic', 'general general wasiwasi', 'arohana ho tšoenyeha', 'matšoenyeho a setjhaba' le 'matšoenyeho a sekolo'. Ha a phahama ka sekhahla, seo se eketsa hore na ngoana o tšoenyehile ka eng. Ho nepahala le ho ts'epahala ho lekane ho People's Republic of China.

Liteko tsa biochemistry

Bakeng sa motho e mong le e mong ea nkang karolo, 5 ml ea mali a venous e ne e nts'oa ho sebelisoa tube ea heparin anticoagulation vacuum, e bolokiloeng e le maemong a batang ka leseli le thibetsoeng. Maemo a DA le NE ka serum a ne a lekantsoe a sebelisa ELISA (enzyme e kopantseng immuno-sorbent assay), mme boemo ba 5-HT liphatlalatsong tsa mali tsa potoloho e lekantsoe le HPLC (high performance fluid chromatography).

Tsamaiso

Barupeluoa le bahlokomeli ba bona ba molao ba ile Setsing sa Bophelo sa Mantlha sa Shanghai ho Shanghai Jiao Tong University School of Medicine. Ho fumanoe tumello e ngotsoeng. Liteko tsohle li ile tsa fanoa ke litsebi tsa bongaka tse ngolisitsoeng 'me tlhaiso-leseling e tsoang ho bona e kenelle ka database ea khomphutha.

Tlhahlobo ea Litekanyetso

Lintlha li ile tsa hlahlojoa ho sebelisoa Statistical Package bakeng sa Saense ea Sechaba (SPSS), mofuta 16.0 ho bapisa lihlopha tsa IAD le tse tsoetseng pele. Meetso e neng e ajoa ka tloaelo, e hlalosoa ke tlhahlobo ea Kolmogorov-Smirnov, kapa e ka fetoloang ho fetisoa ho tloaelehileng e ne e bapisoa ho sebelisoa sampole e ikemetseng. t liteko. Lintlha tse senang parameti li ne li bapisoa ho sebelisoa Mann-Whitney U tlhatlhobo. Li-coefficients tsa sehlahisoa sa pearson li ne li baloa bakeng sa phapang e fapaneng pakeng tsa IAD le lihlopha tse ntseng li eketseha ka mokhoa o tloaelehileng. Hape, liphetoho tsena li ile tsa kenngoa tlhahlobisong ea tokisetso ea likhopolo tsa binary ho khetholla hore na ke mefuta efe e boletsoeng esale pele e ikemiselitseng ho ba setho sa sehlopha sa IAD. Khokahano lipakeng tsa lihora tse sebelisitsoeng marang-rang le lintlha tse ngata tsa SAS / SDS sehlopheng sa IAD li ile tsa khethoa ke Pearson r.

Results

Tekanyo ea Monoamine Neurotransmitters ho Plasma

Tekanyetso ea NE ho sehlopha sa IAD e ne e le tlase ho feta sehlopheng se neng se ntse se hola [(345 ± 68) pg / ml le (406 ± 76) pg / ml, ka ho latellana, t = 2.515, p = 0.017]. Ha ho na phapang e kholo maemong a DA kapa 5-HT lipakeng tsa lihlopha tsena tse peli (Lethathamo 1).

ponahalo e nyane
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Tafole 1. Boemo ba 5-HT, NE le DA ho IAD le lihlopha tsa taolo.

doi: 10.1371 / journal.pone.0063089.t001

Lipontšo tsa Boithati

Likolo tsa SDS, SAS le SCARED sehlopheng sa IAD kaofela li ne li phahame haholo ho feta sehlopheng se tloaetseng ho hola (Lethathamo 2).

ponahalo e nyane
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Tafole 2. Ho bapisoa le bongata ba lipontšo tsa maikutlo tse tlalehiloeng mahareng a IAD le lihlopha tse laoloang.

doi: 10.1371 / journal.pone.0063089.t002

Correlation ea Boikoetliso ba Matšoao a Emotional ka Boemo ba NE

Li-coefficients tsa sehlahisoa sa Pearson bakeng sa IAD le lihlopha tse ntseng li eketseha ka mokhoa o tloaelehileng li pakeng tsa −0.26 ho −0.29 bakeng sa boemo ba NE le lintlha tse ngata tsa SDS, SAS le SCARED (r = −0.263, −0.269 le −0.294, ka ho latellana).

Tlhatlhobo ea Logistic ea Logistic

Mefuta e ikemetseng e keneng mohopolong oa thepa e ne e le boemo ba NE le li-SDS, SAS le lintlha tsa SCARED. Nako le bong e ne e boetse e nkuoa e le mefuta e ikemetseng. Ho fetotsoe lintho tse peli tekong ea regression: palo ea SAS (V1) le boemo ba NE (V2) (Lethathamo 3). Liperesente tse nepileng ka kakaretso e ne e le 80.0% (equation equation: logit (P) = −14.729+0.475×V1−0.031×V2).

ponahalo e nyane
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Tafole 3. Liphetho tsa ho khutla hoa mantlha ha boemo ba NE le botebo ba matšoao a maikutlo a tlalehiloeng ka tlhahlobo ea IAD kapa che (Bacha ba 20 ba nang le taolo ea IAD le 15).

doi: 10.1371 / journal.pone.0063089.t003

Khokahano ea Lihora Spent Online le Scores tsa SAS / SDS Har'a Bacha ba nang le IAD

Har'a bacha ba 20 ba nang le IAD, kopanelo ea lihora tse sebelisitsoeng marang-rang ka beke ho ea ho lintlha tsa SAS e ne e se ea bohlokoa lipalo-palo (r = 0.015, p = 0.955), leha e le hore hoo ho ne ho fihla ho palo ea SDS (r = 0.015, p = 0.954).

Puisano

Ho fumana hore bacha ba nang le IAD ba phahamisitse matšoenyeho le matšoao a sithabetsang ho lumellana le mosebetsi o fetileng: Bernardi et al. [23] e fumane hore 30% ea bacha ba nang le IAD ba na le maemo a bohlokoa a khatello ea kelello. Lithuto tse ling li hlokometse mokhatlo o moholo oa monyetla oa IAD o nang le khatello ea maikutlo [7], [9], [24], [25] le menyetla e eketsehang eo bacha ba nang le lefu la khatello ea maikutlo ba ka bang le eona IAD [26], [27]: Haholo-holo, teko ea rona e laoloang ka mokhoa o hlophisitsoeng e sa tsoa khethoa e fumane hore bacha ba nang le IAD ba ntlafalitse matšoenyeho le matšoao a sithabetsang kamora kalafo ea boits'oaro ea kelello [28].

Ho khahlisang ke hore, le ha mosebetsi o fetotsoeng oa DA, NE le 5-HT o hokahantsoe le matšoenyeho a bohlokoa a bongaka le matšoao a sithabetsang, re fumane hore ke boemo ba NE feela bo neng bo le tlase mme ba itlaleha ba tšoenyehile ka holimo sehlopheng sa IAD ha se bapisoa le sehlopha se ntseng se hola ka tloaelo.. Ho feta moo, boemo bo tlase ba NE bo ne bo hokahane hanyane ka hanyane ke ho tšoenyeha le matšoao a sithabetsang.

Ka hona, mathata a ho feto-fetoha ha maikutlo le maikutlo a mantlha ho bacha ba nang le IAD a ka 'na a amahanngoa le ts'ebetso e fetotsoeng ea tšebetso ea monoamine: leha ho le joalo, 5-HT le DA li ne li sa sebetse, ho fana ka maikutlo a hore ho ka ba le lebaka le ikhethang la bioloji le amanang le IAD bohlankaneng. Tlhaloso e 'ngoe ea bohlokoa ea sena e ka ba hore dopamine e matlafalitsoeng ea ho matlafatsa boits'oaro bo sa amaneng le IAD, joalo ka mefuta e meng ea bokhoba ba ho lemalla. [29]. Leha ho le joalo, kaha Ne ke sehlahisoa sa metabolic sa DA, tlhahlobo e eketsehileng ea ts'ebetso ea hlokahala. Zhu et al. [30] haufinyane tjena u hlokometse hore liphetoho lipakeng tsa mali a NE a ka tsamaisana le kalafo e sebetsang ea IAD le matšoao a amanang le khatello ea maikutlo le a ho tšoenyeha. Hape, liteko tse laoloang nakong e tlang lia hlokahala.

Leha lithuto tse fetileng [17], [31] fana ka maikutlo a kamano pakeng tsa lihora tse sebelisitsoeng marang-rang le khatello ea maikutlo / matšoenyeho, ha rea ​​fumana kamano e ntle hakana thutong ena. Ho hlalosa phapang, ho ka ba le lintlha tse ling tse lokeloang ho ithutoa ntle le litaelo tse fapaneng tsa tlhahlobo ea maikutlo (SCL-90 lithutong tse peli tse fetileng le SAS, SDS thutong ea rona).

Ho na le mefokolo e 'maloa thutong ena e hatellang tlhaloso ea sephetho. Taba ea pele, boholo ba sampole bo ka lebisa ho mofuta o nyolohang oa 1 le 2. Taba ea bobeli ke hore maemo a lekanyelitsoeng a lilemo le karolelano ea bong e bolela hore litlatsetso mabapi le sethala sa ntlafatso le bong li ka se huloe. Taba ea boraro, ho haella ha tlhaiso-leseling e bolele hore ha ho lits'oants'o tse ka hlahisoang ho tsoa mekhatlong ea bohlokoa e hlahisitsoeng. Ka mokhoa o hlakileng, mehlala e meholo ea malelele ea bashanyana le banana, ho tloha bongoaneng, bohlankaneng le ho ba motho e moholo ea hlalosoang ka hloko bakeng sa mathata a IAD le bohlokoa ba "comorbid", a tsoang litsing tse ngata a ka sebetsana le meeli ena. Ntle le moo, tlhahlobo ea nako e tlang ea maemo a NE a ntlafalitsoeng litekong tsa kalafo tse laoloang ea hlokahala.

Menehelo ea Mongoli

Rea tseba le ho hlophisa liteko: WQJ YSD. O entse liteko: WQJ YSD ZGL. Hlahloba data: HXZ AV YSD. Li-reagents tse kentsoeng / lisebelisoa / lisebelisoa tsa tlhahlobo: WQJ HXZ YSD. Ngola pampiri: HXZ AV.

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