J Chromatogr B Mohlophisi oa Technol Biomed Life Sci. 2017 Mots'eanong 1; 1057: 24-31. doi: 10.1016 / j.jchromb.2017.04.046.
Cho YU1, Lee D2, Lee Lee1, MANG KH3, Lee DY4, Jung YC5.
inahaneloang
Morero oa mantlha oa lipatlisiso tsa hajoale ke ho khetholla li-molecular dynamics tse amanang le bothata ba lipapali tsa inthanete (IGD) ho sebelisa profiling ea methapole e sa reretsoeng ea plasma e ipapisitse le khase ea chromatography ea nako ea ho fofa (GC-TOF MS). IGD ke lefu la kelello le hlohlellelitsoeng ke papali ea inthanete e fetelletseng le e telele, e neng e arolelana matšoao a mangata a mafu le khatello ea kelello ea khatello ea kelello (ADHD). Ho ata ha lefu lena ho eketsehile ka potlako haholo-holo linaheng tsa Asia Bochabela (5.9% Korea Boroa) ha ho bapisoa le Europe kapa Amerika Leboea (0.3-1.0% United States le 1.16% Jeremane). Kahoo re ile ra batlisisa ka mokhoa o ts'oanang khokahano lipakeng tsa methapo ea mali ea mali le matla a ho lemalla inthanete ho bakuli ba IGD, le likarolo tse ka bang teng tsa biomarker hammoho le likarolo tsa bongaka. Ho hlophisoa ka mokhoa o hlophisehileng oa li-sampuli tsa mali tsa 54 (mosebelisi ea tloaelehileng, N = 28 le IGD, N = 24) ho supile palo e felletseng ea li-metabolite tse 104 ho tsoa ts'ebetsong ea 1212 ea metabolic, mme e senotse kamano e ikhethileng ea li-metabolism tsa li-plasma tsa methapole (arabitol, myo-inositol, methionine, pyrrole-2-carboxylic acid, le aspartic acid) ka sekhahla sa ho lemalla lithethefatsi (R = 0.795). Ntle le moo, tlhahlobo ea khethollo e khethiloeng ka makhetlo a mabeli (OPLS-DA) le tlhahlobo ea ts'ebetso ea li-receiver (ROC) e ile ea supa sehlopha se ka bang teng sa biomarker se neng se khetholla mefuta e fapaneng ea boemo ba kelello. Sesebelisoa se ka hlahisoang hape sa biomarker se ile sa hlahlojoa ka botlalo ke sehlahlobo sa moamoheli se sebetsang (ROC) moo li-AUC e neng e le 0.890, 0.880, 1.000, le 0.935 bakeng sa taolo, IGD, AD le IGD + AD, ka ho latellana (N = 18, 19, 5 , le 10) khahlanong le tse ling. Mokhoa ona oa ho fuputsa o ka fana ka matla a ho tseba esale pele ka tlhahlobo ea baahi ea IGD. Likarolo tse khethiloeng tsa metabolic, kamano le likarolo tsa bongaka, le khokahano ea likokoana-hloko ea putative ka ts'epo li tla thusa lithuto tsa kamoso tsa mafu ho IGD.
LIHLOOHO: Sehlopha sa Biomarker; Khase ea chromatography ea boholo ba nako ea ho fofa (GC-TOF MS); Ho tiea ha lithethefatsi ho Internet; Mathata a ho bapala Inthaneteng (IGD); Metabolite ea lero la mali
PMID: 28482325
DOI: 10.1016 / j.jchromb.2017.04.046
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