Setšoantšo se sebetsang sa mahlaseli a marang-rang a ho lemalla internet ho batho ba baholo (2016)

 

inahaneloang

SEHLOOHO: Ho tlaleha sephetho sa lithuto tsa matla a tšebeliso ea matla a kelello (fMRI) mabapi le ts'ebeliso ea ts'ebeliso ea ts'ebeliso ea marang-rang ho batho ba baholo.

Mekhoa: Re entse tlhahlobo e hlophisehileng ho PubMed, ra tsepamisa maikutlo a rona lithutong tsa fMRI tse kenyelletsang bakuli ba IAD ba baholo, ba lokolohileng maemong afe kapa afe a kelello. Ho sebelisitsoe mantsoe a latelang a patlo, a le mong ebile a kopantsoe: fMRI, bokhoba ba marang-rang, ho itšetleha ka marang-rang, neuroimaging e sebetsang. Patlo e entsoe ka la X20th, 2015 mme ea hlahisa rekota ea 58. Litekanyetso tsa kenyelletso e ne e le tse latelang: Lingoloa tse ngotsoeng ka Senyesemane, lilemo tsa bakuli ≥ lilemo tsa 18, bakuli ba anngoeng ke IAD, lithuto tse fanang ka liphetho tsa fMRI nakong ea ho phomola ha mmuso kapa ho ba le kelello / maikutlo. Lithuto tsa MRI tsa sebopeho, mekhoa e sebetsang ea ho nahana ka ntle le fMRI, lithuto tse amang bacha, bakuli ba nang le mafu a kelello a kelello, a methapo kapa a tsa bongaka a ne a sa qheleloe ka thoko. Ka ho bala lihlooho le litlolo, ha re kenyetse li-rekoto tsa 30. Ka ho bala lingoliloeng tse felletseng tsa lingoloa tse setseng tsa 28, re bonts'a lipampiri tsa 18 li kopanang le litekanyetso tsa rona tsa ho kenyeletsoa ka hona li kenyellelitsoe tlhaisong ea boleng.

LITLHAKISO: Re fumane lithuto tsa 18 li phethahatsa mekhoa ea rona ea ho kenyelletsa, 17 ea tsona e etsoang Asia, hape ho kenyelletsa palo e felletseng ea lithuto tsa 666 tse lekiloeng. Lithuto tse kenyelelitsoeng li tlalehiloe ka datha tse fumanoeng nakong ea ho phomola kapa maemo a fapaneng, joalo ka ho hlophisoa bocha, ho noha kapa ho laola mesebetsi. Bakuli ba ngolisitsoeng hangata e ne e le banna (95.4%) mme ba le banyenyane haholo (lilemo tsa 21-25). Subtype e emeloang haholo, e tlalehiloeng ho bakuli ba fetang 85%, e ne e le bothata ba lipapali tsa marang-rang, kapa bokhoba ba videogame. Lithutong tsa mmuso tse phomotseng, litlolo tse loketseng li ne li fumaneha libakeng tse phahameng tsa moea oa nakoana, li-legic, li-frontal tsa pele le tsa parietal. Ha re hlahloba lithuto tse amanang le fmri tse amanang le mosebetsi, re fumane hore lipampiri tse ka tlase ho halofo li tlaleha karohano ea boitšoaro lipakeng tsa bakuli le taolo e tloaelehileng, empa kaofela ba fumane phapang e kholo literekeng tsa boko ba cortical le subcortical tse amehang taolong ea kelello le ts'ebetsong ea moputso: Orbitof Pambal cortex, insula, anterior le posterior cingrate cortex, libaka tsa nakoana le tsa parietal, stem ea boko le nucleus ea caudate.

TLHOKOMELISO: IAD e ka ama ka ho teba mesebetsi ea boko ba batho ba baholo. E hloka ho ithutoa ka botebo ho fana ka tlhahlobo e hlakileng ea kalafo le kalafo e lekaneng.

Keywords: Tebello ea marang-rang, Tšebeliso ea marang-rang ea marang-rang, ts'ebetso ea ts'ebetso ea matla a matla a khoheli, bothata ba lipapali tsa inthanete, ts'ebetso ea ts'ebetso ea ts'ebetso.

Keletso: Re shebile ka mokhoa o hlophisehileng lithuto tse sebelisang matla a ho nahana ka boloi ho batho ba baholo ba anngoeng ke ts'ebeliso ea ts'ebeliso ea ts'ebeliso ea marang-rang (IAD), ntle le boemo bo bong ba kelello. Re fumane lithuto tsa 18, hangata li etsoa Asia Bochabela le ho ngolisa banana ba banyenyane ba nang le bothata ba lipapali tsa marang-rang. Babuelli ba marang-rang ba bonts'itse liphetoho tse sebetsang libakeng tse amehang taolong ea kelello le moputso / kutloelo ea kotlo (orbitofrontal cortex, anterior and posterior cingate, insula, dorsolateral prefrontal cortex, temporoparietal, brain stem and caudate nucleus . IAD ke boemo bo nyahamisang bo hlokang ho nahanoa ka hloko ka lebaka la tšusumetso ea eona e matla tšebetsong ea boko ba bacha.

SELELEKELA

Boloetse ba taolo ea marang-rang (IAD), bo boetseng bo bitsitsoeng pathologic / bothata ba tšebeliso ea marang-rang (PIU), bo ka hlalosoa e le bothata ba taolo ea tšusumetso e khetholloang ke tšebeliso e sa laoloang ea Marang-rang, e amanang le ho senyeha hoa ts'ebetso kapa khatello ea kelello []. IAD ha e khetholloe joalo ka bothata ba kelello ho khatiso ea Diagnostic and Statistical Manual of Mental Disorders-Labohlano, empa subtype ea IAD, bothata ba lipapali tsa marang-rang (IGD) (hape bo bitsitsoeng videogame addiction), bo kenyelelitsoe karolong ea 3 e le sehlooho e lokela lithuto tse tlang []. Tlhahlobo ea morao-rao ea meta mabapi le IAD [] e kenyelletsang barupeluoa ba fetang 89000 ba tsoang lichabeng tsa 31 e tlaleha tekanyo ea lefatše ka bophara ea 6%, ka tlhaselo e phahameng ho Middle East (10.9%) le tlhaselo e tlase ka ho fetisisa Europe Leboea le Bophirima (2.6%). Ho ata ha IAD ho ne ho amana haholo le maemo a tlase a tikoloho le tikoloho. Phuputso e sa tsoa etsoa ho baithuti ba koleche ea India [] ho tlaleha 8% ea IAD e leka-lekaneng 'me e khethollotse mefuta e latelang e le mabaka a kotsi: Bong ba banna, ho fumaneha ho tsoelang pele inthaneteng, ho sebelisa marang-rang ho etsa setsoalle / likamano tse ncha le tse fokolang bakeng sa thupelo / mosebetsi. Ka lebaka la bokhoni ba bona bo phahameng ba k'homphieutha le phihlello e bonolo ea inthanete, batho ba baholo ba kotsing ea ho ba IAD [].

Tse ling tsa litšobotsi tsa bongaka tsa IAD li ts'oana le tse bonoang ho ts'ebeliso e mpe ea tšebeliso e mpe ea lithethefatsi (tahlehelo ea taolo, ho lakatsa, matšoao a ho tlohela), Obsessive Compulsive Disorder, kapa Bipolar Disorder kahoo mofuta oa IAD (kelello ea mafu a kelello kapa "phapang ea kelello" ea maemo a mang a kelello) e ntse e ngangisana [-].

Mekhoa ea ho nahana ka mokhoa o sebetsang e eketsa monyetla oa ho etsa lipatlisiso ka motheo oa neural oa IAD, ho matlafatsa kutloisiso le matla a lipalo a data ea kliniki. Mokhoa oa ts'ebetso oa matla a ts'ebetso ea matla a matla a khoheli (fMRI), haholoholo ke mokhoa o sebelisoang lefatšeng ka bophara o sa hlaseleng ho ithuta ka ho hlaseloa ha neural underginnings ea mafu a kelello [-]. Ka FMRI, liphetoho tsa lets'oao la boko li ka hlahlojoa ho latela maemo a sebetsang a fetohang mabapi le “basement” bo fanoeng (activation / deactivations) kapa mabapi le khokahano e sebetsang har'a libaka tse fapaneng tsa boko (tlhahlobo ea marang-rang). Liphetoho tsa ts'ebetso ea metabolism bokong li ka shebelloa nakong ea ts'ebetso ea li-paradigms (mosebetsi o amanang le fMRI) kapa nakong ea ts'ebetso ea boikoetliso ba motsoako o mong (phomolo ea mmuso fMRI) [-].

Sepheo sa thuto ea hona joale e ne e le ho lekola ka mokhoa o hlophisehileng lithuto tsa FMRI tse phomotsang le tse amanang le mosebetsi lithutong tsa batho ba baholo le IAD, ho batla li-biomarkers tse tšepahalang tsa boemo bona bo thata ba kelello.

LISEBELISOA LE MEKHOA

Re batlile PubMed ho supa lithuto tsa fMRI tse batlisisang IAD lithutong tsa batho ba baholo. Ho sebelisitsoe mantsoe a latelang a patlo, a le mong ebile a kopantsoe: fMRI, bokhoba ba marang-rang, ts'ehetso ea inthanete, ts'ebetso ea ts'ebetso. Patlo e entsoe ka la X20th, 2015 mme ea hlahisa rekota ea 58.

Litekanyetso tsa kenyelletso e ne e le tse latelang: Lingoloa tse ngotsoeng ka Senyesemane, lilemo tsa bakuli ≥ lilemo tsa 18, bakuli ba anngoeng ke IAD, lithuto tse fanang ka liphetho tsa fMRI nakong ea ho phomola ha mmuso kapa ho ba le kelello / maikutlo. Lithuto tsa MRI tsa sebopeho, mekhoa e sebetsang ea ho nahana ka ntle le fMRI, lithuto tse amang bacha, bakuli ba nang le mafu a kelello a kelello, a methapo kapa a tsa bongaka a ne a sa qheleloe ka thoko.

Ka ho bala lihlooho le litlolo, ha re kenyetse li-rekoto tsa 30. Ka ho bala lingoliloeng tse felletseng tsa lingoloa tse setseng tsa 28, re bonts'a lipampiri tsa 18 li kopanang le litekanyetso tsa rona tsa ho kenyeletsoa ka hona li kenyelelitsoe ho tlhaiso-leseling ea boleng (Figure11).

Setšoantšo sa 1   

Tšebeliso ea flow ea tlhahlobo e hlophisehileng.

Biostatistics

Lipalopalo li entsoe ke Dr. Gianna Sepede, ea nang le boiphihlelo bo netefalitsoeng ho Lipalopalo tsa Biomedical, Tlhahlobo ea Tsamaiso le tlhahlobo ea Meta. Leqepheng la hona joale, lenane la tlhahlobo ea PRISMA 2009 (http://www.prisma-statement.org/) e sebelisitsoe ho hlalosa mekhoa ea ho tšoaneleha, tsamaisa lipatlisiso, khetha lithuto le ho tlaleha sephetho sa tlhaiso ea boleng. Mekhoa ea lipalo-palo e ile ea hlalosoa ka nepo, e nepahetse mme e tsamaisoa ka data e homogeneous. Palo ea lithuto le li-dropouts li fanoe. Ha ho loketse, ho ba le kholiseho ebile ho bohlokoa P boleng bo ile ba baloa 'me ba tlaleheloa.

LIPOTSO

Re fumane lipampiri tsa 18 li phethahatsa litekanyetso tsa rona tsa ho kenyeletsoa, ​​kaofela li phatlalalitsoe ho tloha 2009 ho 2015 [-]. Lithuto tsena kaofela li entsoe Continental Asia (China, Korea Boroa, Taiwan), ntle le pampiri e hatisitsoeng ke Lorenz et al [], e neng e tšoaretsoe Jeremane.

Ka kakaretso, lithuto tsa 666 li ile tsa lekoa ke lithuto tsa 18 tse kenyellelitsoeng ho lingoloa tsa maemo: Bakuli ba 347 ba nang le IAD (IADp), 304 lipapiso tse tloaelehileng (NC) le lithuto tsa 15 tse nang le Alcohol Use Disorder (AUDp) Bongata ba IADp e ne e le banna (n = 331, 95.4%) hape o le monyane haholo (bolele lilemo li pakeng tsa 21 ho isa ho 25 selemo). Palo ea bakuli ba amehang thutong e 'ngoe le e' ngoe e ne e tloha 8 ho isa 74. Bakeng sa eng mabapi le subtypes ea IAD, 15 ho tsoa lithuto tsa 18 tse tsepamisitsoeng ho IGD [-,-], haholo ho feta 85% ea IADp eohle (n = 297) e ne e le bakuli ba IGD (IGDp). Ho ile ha sebelisoa mekhoa e fapaneng ea tlhahlobo ho hlahloba IAD, joalo ka Beard's Diagnostic criteria ea ho lemalla lithethefatsi Inthaneteng [], Litekanyetso tsa tlhahlobo ea Ko tsa ho lemalla lithethefatsi tsa inthanete bakeng sa liithuti tsa koleche [], Teko ea bokhoba ba inthanete ea China (C-IAT) [] le mekhoa ea ho lemalla papali ea komporo ea Grüsser le Thalemann [].

Potso e sebelisitsoeng haholo ho lekola ho teba ha IAD e ne e le IAT ea Young [], ka khaolo e fapaneng (hangata> 80, lithutong tse 'maloa> 50). Ho hlahloba IGD, papali ea inthanete le eona e ne e hlokahala hore e be tšebetso e ka sehloohong ea inthanete (nako e fetang 80% ea nako e sebelisitsoeng marang-rang kapa ho feta 30 h / wk).

Bakeng sa ho qhela lithuto tse nang le maemo a kelello a kelello kapa mathata a tšebeliso ea lithethefatsi, lipuisano tse hlophisitsoeng le likala tsa psychometric ho sebetsana le khatello ea maikutlo, ho tšoenyeha, ho hloka matla, tlhekefetso ea lithethefatsi hangata li fanoa.

Lintlha tsa MRI li fumanoe ka scan ninemanga ea 3 T lithutong tsa 17, le sehatisi sa 1.5 T thutong e le 'ngoe []. Litlalehong tsa 4, ho tlalehiloe feela fMRI ea mmuso, athe lingoloa tsa 13 li tlaleha data e amanang le fMRI, mme pampiri e le 'ngoe e fumane ts'ebetso ea ts'ebetso ea mmuso le mesebetsi e amanang le mosebetsi []. Boithuto bo leshome le metso e supileng e ne e le litlaleho tse shebaneng le tse ling, athe pampiri e ngotsoe ke Han et al [] e ne e le thuto ea 6-wk longitudinal.

Barupeluoa lithutong tse khethiloeng tsa 18 kaofela ba ne ba se na kalafo ea psychopharmacological ka nako ea ho phenya (le ho kena thutong bakeng sa thuto e boletsoeng ka holimo ea longitudinal).

Ho khutlisetsa lithuto tsa fMRI tsa naha ho IAD

Palo eohle ea lithuto tse hlano e ile ea khethoa [,,,,]. Tšobotsi ea lihlopha le sephetho sa lithuto li tlalehiloe ho Letlapa Lethathamo1.1. Ho tsamaea ka letsohong le letona e ne e le sesupo sa kenyelletso lithutong tsa 4 [,,,], hammoho le bong ba monna [,,,]. Palo e felletseng ea lithuto tsa 298 (Ba batona n = 280, 94%), meriana eohle e sa lefelloe, e ne e ameha: 159 IADp (140 IGDp), 124 NC le 15 AUDp. Hangata bakuli ba ne ba le banyenyane haholo (ho bolela lilemo tse tlohang ho 21 ho isa lilemong tsa 24).

Lethathamo 1   

Ho khutlisetsa lithuto tsa ho nahana ka matla a naha tse sebelisang matla a ho lemalla marang-rang

Lithutong tsohle tse hlano tse khethiloeng, litšoantšo tsa fMRI li ile tsa fumanoa li sebelisoa ka skena sa 3 T 'me nako ea scan ninete e ne e tloha 7 ho isa ho 9 min. Phumano e kopanyang mesebetsi ea mmuso (RsFc) le / kapa Regional Homogeneity (ReHo) e ile ea balelloa ho lekola lipakeng tsa liphapang tsa sehlopha. Ka lebaka leo, lithuto tsohle tse khethiloeng li bontšitse phapang e kholo lipakeng tsa bakuli le taolo.

Liu et al [], lipatlisisong tsa bona ho bakuli ba 19 IAD, ba tlaleha khokahano e eketsehang har'a libaka tse ka pele, cingulate gyrus, tempirit le occipital, cerebellum le stem ea boko, mabapi le papiso e tšoanang. Kahoo lingoli li khothalelitse khokahano e fetotsoeng e sebetsang libakeng tseo e leng karolo ea tsamaiso ea boko. Lipampiri tsohle tse 'ne li lebisitse ho bakuli ba IGD [,,,] e tlalehile bohlokoa lipakeng tsa litlamorao tsa sehlopha. Dong et al [] o hlokometse hore, ha e bapisoa le taolo, bakuli ba IGD ba bonts'itse ReHo e ntlafalitsoeng libakeng tsa khokahanyo ea sensorimotor (brainstem, cerebellum, bilarial inferior parietal lobule, and left left frontal gyrus), le ReHO e fokotsehileng ka lehlakoreng le ka lehlakoreng le letšehali la "cortex". Mohlala o moholo oa bakuli ba IGD, Dong le basebetsi mmoho [] e bone khokahano e fokotsang ts'ebetso libakeng tse e leng karolo ea Executive Control Network, haholo makaleng a ka letsohong le letšehali: Ventromedial prefrontal cortex, dorsolateral prefrontal cortex le portetal cortex.

Phuputsong e sa tsoa etsoa, ​​Kim et al [] bapisa ts'ebetso ea ts'ebetso ea ts'ebetso ea ts'ebetso ea bakuli ba IGD eseng feela ka lithuto tse phetseng hantle, empa le sehlopha sa bakuli ba AUD, ba batla ho tšoana le liphapang lipakeng tsa "maemo ana a tlatsetsang". Ka lebaka leo, ba fumane hore ka bobeli IGD le AUD li arolelane ReHo e ntseng e eketseha ka kamoreng e ka morao ea cingxe ea cortex mabapi le taolo e phetseng hantle, athe ReHo e neng e fokotsoe ho "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" "" " Bangoli ba boetse ba tlaleha khokahano e mpe lipakeng tsa "cortex" e tlase e tlase ea lefats'e le boemo ba ho se ts'oanelehe.

Ho lekola karolo ea "cortex" e sa kenyelelitsoeng ho IGD, Zhang et al [] o entse liphuputso tsa khokahanyo ea mmuso e thehiloeng ho peo ho bakuli ba 74 ba nang le IGD mme a ba bapisa le taolo e tloaelehileng ea 41. Bakuli ba IGD ba bonts'itse rsFC e ntlafalitsoeng pakeng tsa insula ea kahare le cterex ea methapo, precuneus, gylus ea angular le basal ganglia (libaka tsohle tse kenyelletsoeng taolong ea kelello, ho se tsotelle, ho tsotella le ho lakatsa). Ha ba hlahlobisisa karolo e ka morao ea mochoporo, ba ile ba fumana moea o ntlafalitsoeng oa mafapha libakeng tse bapala karolo ea bohlokoa ho kopaneng le maikutlo a makoloi, joalo ka gyrus ea mantlha le ea pele. Ntle le moo, ba hlokometse khokahano e nepahetseng lipakeng tsa khokahano ea "gyrus" ea nakoana ea moea le boemo ba boima ba IGD.

Ha re akaretsa lithuto tsa rsfMRI, litlolo tse amanang hantle le ho feta tse hlokometsoeng ho IGD li ile tsa fumaneha sebakeng sa boemo bo phahameng ba nakoana. Liphetoho tse ling tsa bohlokoa li ile tsa bonoa libakeng tse nang le maoto le matsoho, libakeng tsa mabopo a ka pele (sebaka sa anterior cingrate cortex, sebaka sa tlatsetso sa makoloi) le libaka tsa parietal. Liphetho tsa ho se bapale IAD ho ea lipapali li ne li fokotsoe ka lebaka la palo e fokolang ea bakuli ba amehang (n = 19) mme ea tlaleha hore e fetotse ts'ebetso libakeng tse amanang le moputso (bokapele, parietal, libaka tsa nakoana, gyrus, stem ea boko le cerebellum).

Lithuto tse amanang le fMRI tse amanang le mosebetsi ho IAD

Re fumane lithuto tsa 14 tse tlaleha li-amanang le neural tse amanang le mosebetsi oa IAD [,,,-,]. Tšobotsi ea lihlopha le sephetho sa lithuto li tlalehiloe ho Letlapa Lethathamo2.2. Ho tsamaea ka letsoho le letona e ne e le sesupo sa kenyelletso lithutong tsohle ntle le tse peli feela [,]. Ke karolo ea banna feela e ileng ea kenyeletsoa lithutong tsa 13, athe sampole e kopaneng ea bong e ngolisitsoe ke Liu et al [] (2015).

Lethathamo 2   

Lithuto tse amanang le tšebetso ea maiketsetso tse amanang le bokhoba ba taolo ea marang-rang

Palo e felletseng ea lithuto tsa 368 (ba batona n = 352, 95.6%: Lilemo tse bolelang ho tloha ho 21 ho isa lilemong tsa 25) li ne li kentse letsoho: 188 IADs (IGDs n = 157) le 180 NC. Barupeluoa kaofela ba ne ba se na meriana hang ka nako ea ho hlahlojoa le ha ho ithutoa ho kenella bakeng sa thupelo ea nako e telele ke Han et al []. Litšoantšo tsa FMRI li ile tsa fumanoa ho sebelisoa scan ninemanga ea 3 T le bolelele ba skena bo pakeng tsa 5 ho isa 30 min.

Litaba tse tataisitsoeng ho barupeluoa e ne e le: mesebetsi ea ho etsa lintho tse ncha (lithuto tse tharo) [,,], mesebetsi ea ho hakanya (lithuto tse tharo) [,,] kapa mesebetsi ea taolo ea kelello ea mefuta e fapaneng (lithuto tse robeli) [-,-]. Ho feta halofo ea lithuto [,,,,,,,] ha ho karohano ea boits'oaro e fumanoeng lipakeng tsa linyeoe le taolo, empa kaofela li tlalehetse litlamorao tse kholo tsa sehlopha ts'ebetsong e sebetsang ea likarolo tse 'maloa tsa boko, haholo-holo orbitofrontal gyrus, anterior cingate cortex, insula, dorsolateral preortal cortex, precuneus, posterior cingates cortex le gerrus e kholo ea nakoana. .

Likarolong tsa cue-reacaction paradigms, lithuto tse lemalloang li pepesoa tšusumetso e etselitsoeng ho tsosa takatso ea ntho kapa boits'oaro: Boemong ba IAD, ke hore., ho shebella litšoantšo kapa livideo tse amanang le videogames kapa maemo a marang-rang [,,].

Mesebetsing ea ho noha e makatsang, barupeluoa ba kopuoa ho becha ka liphetho tse fapaneng (ke hore., ka likarete, li-dice, mebala) le karabelo ea bona ea kelello ho maemo a ho hlopha kapa a tahlehelo e ka hlahlojoa, ho lekola moputso le likotlo tsamaiso ea neural [].

Mesebetsing ea taolo ea kelello, barupeluoa ba tlameha ho khetha pakeng tsa likarabo tse fapaneng tse fapana. Stimuli e ka sebelisoa ho eketsa mathata le ho lekola bokhoni bo itseng ba kelello, bo joalo ka tlhokomelo e tsitsitseng, thibelo ea karabelo, ho hloka matla, bokhoni ba phetoho ea mesebetsi le ts'ebetso ea liphoso. Mesebetsi ea taolo e sebelisoang khafetsa ke mesebetsi ea Stroop: Barupeluoa ba lebelletsoe ho fumana feela tšobotsi e ikhethang ea sepheo, ba hlokomolohang ba bang (ke hore., mantsoe a mebala a hatisitsoeng ka enke ea mebala e fapaneng mme barupeluoa ba tlameha ho hlokomoloha lentsoe le ho reha 'mala oa lona) []. Ha likarolo tse fapaneng tsa tšusumetso e le tse sa sebetseng, bothata ba mosebetsi bo eketseha mme bo ama ts'ebetso (Stroop athari) []. Karolo e ngoe ea bohlokoa ea mesebetsi ea taolo ke "u se ke ua ea paradigm": Stimuli (ke hore., litaele, litlhaku, libopeho) li hlahisoa mohloling o tsoelang pele mme barupeluoa ba etsa qeto ea binary ka khothalletso e ngoe le e ngoe. E 'ngoe ea liphetho e hloka hore barupeluoa ba arabe karabo ea koloi, athe e mong o hloka hore barupeluoa ba se ke ba araba (ho se ee) [].

Ha thuto e shebane le tšusumetso ea maikutlo kapa ho se tsotelle ho khethollo e khethehileng, ho sebelisoa khafetsa: barupeluoa ba shebella mehopolo e sa nke lehlakore kapa e sa bonahaleng e hlahang ka tšohanyetso lehlakoreng le leng la skrine, ebe ho hlahisoa letheba sebakeng sa tšusumetso e 'ngoe ea pele mme litho tsa sehlopha li lokela ho bonts'a sebaka se nepahetseng sa letheba, ka hona, khethollo e shebileng pele e susumetsoa ke maikutlo a manyane [,].

Mosebetsi oa Cue-reactivity fMRI lithuto tsa IAD

Thutong ea bona ea 10 IGDp e lemaletse videogame World of Warcraft (WOW) Ko et al [] e fumane hore IGDp e tlalehile tlhoko e phahameng ea papali ha u sheba litšoantšo tsa WOW mabapi le NC. Ntle le moo, ts'ebetso e kholo ea ts'ebetso e ile ea bonoa ka cortex e nepahetseng ea orbitof Pambal, basal ganglia (caudatum le accumbens), habeli ea "cortate" ea cortex ea linaha tse peli, setulo se ka pele sa tsebe ea methapo ea methapo.

Han et al [] o entse tlhahlobo ea lipale tsa bongaka tse bulehileng tsa libeke tse tšeletseng tse ikemiselitseng ho lekola katleho ea bupropion ho fokotsa takatso ea lipapali le ho kenya ts'ebetsong ts'ebetso ea ts'ebetso ea kelello ho 11 IGDp e lemaletseng videogame Starcraft. Motheong, barupeluoa bohle ba ne ba se na meriana 'me bangoli ba hlokometse papali e phahamisang le ts'ebetso e matlafalitsoeng ea cortex ea dorsolateral pele, L parahippocampus, ba tlohetse occipital lobe le cuneus ho IGDp, mabapi le NC nakong ea tlhahiso ea Starcraft cue. Kamora kalafo ea bupropion, ts'ebetso e kholo e fokotsehileng ea cortex ea dorsolateral ea pele e bonoang ho IGDp. Bupropion, ka ho ba moemeli oa litlhare tsa phepo e tsamaisang dopamine le norepinephrine reuptake, ho tlalehiloe hore e ne e sebetsa hantle ho bakuli ba nang le bothata ba tšebeliso ea lithethefatsi, kapa ba nang le mathata a ho feto-fetoha ha maikutlo ka comorbid [,] le papaling ea papali ea chelete []. Kahoo bangoli ba netefalitse hore bupropion e fokotsa ho lakatsa ho IGD ka ho fetola ts'ebetso ea ts'ebetso ea dorsolateral pele.

Phuputsong e sa tsoa etsoa e susumetsang videogame stimuli, Liu et al [] (2015) o ngotse sampole e kopaneng ea bong ba 19 IGDp (banna ba 58%) mme a tlaleha ts'ebetso e kholo ea cortex ea kapele, ka ts'ebetso e eketsehang libakeng tse ka lehlakoreng le letona tsa temporo-parietal le legic: Superior parietal lobe, insula, cingulate gyrus le gyrus ea nakoana ea nakoana.

Ho etsa lithuto tsa FMRI tsa ho ithuta mosebetsi ho IAD

Ho lekola menyetla ea moputso le kotlo ho IGDp, Dong et al [] ba etselitse maemo a ho fumana phaello / tahlehelo: Barupeluoa ba ile ba tlameha ho khetha pakeng tsa likarete tse peli tse bapalitsoeng 'me qetellong ea seboka sa fMRI ba ile ba fumana tefo ea chelete ho latela moputso le tahlehelo ea bona. tlhahlobo ea data ea fMRI e senotse hore nakong ea maemo a katleho li-IGD li bonts'itse ts'ebetso e phahameng ea orbitofrontal cortex (BA11) mabapi le NC, athe maemong a tahlehelo a fapaneng le 'nete e ne e le' nete ka ts'ebetso ea cterex ea anterior. Kahoo bangoli ba phethile ka hore kutloisiso e fokotsehileng ea liphihlelo tse mpe (tahlehelo ea chelete) le kutloisiso e ntlafalitsoeng ea liketsahalo tse ntle (phaello ea chelete) ho ts'ebetso e fetotsoeng ea orbitofrontal cortex le cortex ea ka ntle e ka hlalosa lebaka leo IADp e phehellang tloaelong ea bona leha ho bile le litlamorao tse mpe ho bophelo ba bona ba letsatsi le letsatsi.

U sebelisa mosebetsi o tšoanang oa ho noha, Dong et al [] e fumane hore IGDp e ne e lieha haholo ho feta NC ha e pepesetsoa tahlehelo e tsoelang pele, athe litlamorao tsa sehlopha sa boits'oaro li ile tsa bonoa kamora ho hapa khafetsa. Mabapi le ts'ebetso ea ts'ebetso ea boko, li-IGD li bonts'itse ts'ebetso e fokotsehileng ea "posterior cingrate cortex" le ts'ebetso e eketsang ea boemo bo tlase bo kahare nakong ea katleho le tahlehelo, athe ts'ebetso e matlafalitsoeng ea cortex ea ka ntle le ts'ebetso e ile ea bonoa nakong ea maemo a win. Liphetho tsena li bontšitse hore bokhoni ba ho etsa liqeto bo ne bo senyehile ho IGDp, ka lebaka la ho se sebetse hantle ha 'mala o ka pele (ts'ebetso e phahameng empa ts'ebetso e tlase ea boitšoaro) le ho fokotseha ho kenella ha posterior cingrate cortex le caudate. Mohlaleng o le mong oa ho ithuta, le paradigm e fetotsoeng (boemo bo fapaneng ba taolo bo ile ba eketsoa ka katleho le tahlehelo) Dong et al [] e kopile barupeluoa ho hlalosa boiphihlelo ba bona bo kahare ho kamora karolo ea scan: IGDp e tlaleha ho labalabela ho fumana moputso maemong a hlolang le tahlehelo le ho fokotsa maikutlo a fosahetseng nakong ea tahlehelo. Mabapi le ts'ebetso ea ts'ebetso, liphetho li ne li tšoana, empa li sa tšoane le tse tlalehiloeng [] (mohlomong e le ka lebaka la maemo a fapaneng a taolo): IGDp e hokahane le karolo e kaholimo ea lebili le phahameng ka pele ho katleho le tahlehelo (empa boemo ba ts'ebetso bo ne bo phahame nakong ea ho hlola) le hypoactivated posterior cingates cortex nakong ea tahlehelo. Bangoli ba phethile ka hore bokapele bo phahameng ka ho fetesisa ho IGDp e ne e sa nahanele maemo a mabe mme posterior cingrate cortex e ile ea sitoa ho fana ka taolo ea eona ea kelello mabapi le liphetoho tsa tikoloho.

Mosebetsi oa taolo ea cognitive control fMRI ho IAD

Lithutong tse robeli tsa taolo ea kelello tsa fMRI tseo re li khethileng, mesebetsi ea Stroop e sebelisitsoe lithutong tse 'ne [,,,], go / no-go-paradigms mo lithuto tse tharo [-] le letheba le letheba / pradigm thutong e le 'ngoe [].

Dong et al [] o ngolisitse banna ba 12, ba sa sebeliseng lithethefatsi le ba sa tsubeng IGDp mme a ba bapisa le lithaka tse phetseng hantle nakong ea khetho ea mebala e 'meli ea lentsoe la Stroop. Lihlopha ha lia ka tsa fapana ka ts'ebetso ea boits'oaro, empa nakong ea ts'ebetso ea Stroop (incongruent - congruent stimuli papiso) IGDp e bonts'itse khatello e kholo ea anterior cingulate cortex, posterior cingulate cortex, insula insula, bohareng ba pele gyrus, medial frontal gyrus, left thalamus, gyrus e ka tlase e ka pele e nepahetseng, gyrus e kaholimo ho le letona e holimo ka ho le letona.

Bangoli ba boletse hore ts'ebetso e kholo ea ts'ebetso ea posterior cingrate cortex sehlopheng sa IGD e ka bonts'a ho sitoa ho ntlafatsa lisebelisoa tsa tlhokomelo tse amanang le mosebetsi ka lebaka la ho senyeha ho sa feleng ha Default Mode Network. Ho feta moo, hyperactivation ea anterior cingrate cortex, insula le libaka tsa pele li ka bonts'a ho se sebetse hantle hoa libaka tsa mekha ea litho tsa haeso li bapala karolo ea bohlokoa ho lekolleng lintoa le "holimo" taolong ea thibelo.

Mohlala o moholo oa Dong et al [] o tsamaisitse paradigm e ts'oanang ea Stroop ka moralo o amanang le ketsahalo mme a sekaseka ka nepo likarolo tsa tšebetso tsa likarabo tse nepahetseng le tse phoso ho susumetsa. IGDp le NC li sebelitse ka mokhoa o ts'oanang, empa ho fapana ho ileng ha hlaha ka mekhoa ea ts'ebetso: nakong ea likarabo tse nepahetseng IGDp e ile ea sitoa ho kenya cortex ea anterior cortex le orbitofrontal cortex, athe ts'ebetso e mpe ea cortex ea anterior e ile ea bonoa nakong ea liphoso, ka hona e fana ka maikutlo a bokhoni ba ho lekola phoso.

Haufinyane tjena, Dong et al [] a hlahloba ho tenyetseha ha boiphihlelo ba sehlopha sa IGD nakong ea mofuta o fetotsoeng oa mosebetsi oa Stroop, a eketsa moputso oa chelete bakeng sa likarabo tse nepahetseng le ho theha maemo a bonolo le a boima a mosebetsi. Sehlopha sena se ne se sa fapana ka tsela e fapaneng. Ka lehlakoreng le leng, ha ts'ebetso e fetoha ho tloha maemong a thata ho isa ho a leng bonolo IGDp e ile ea kenya ts'ebetsong ts'ebetso ea lefats'e le lefats'e le phahameng ho feta li-NC; ha mosebetsi o fetoha ho tloha maemong a bonolo ho isa ho a boima, ba ile ba kopanya li-precuneus tse peli, ba siea gyrus ea nakoana mme ba siea gyrus e ntle. Bangoli ba pheha khang ea hore ts'ebetso e phahameng (mme ka hona e sa sebetseng hantle) ea libaka tsa maoto le tsa temporoparietal tse bapala karolo ea bohlokoa taolong ea thibelo le ho fetoha ha maemo ho hlakileng e ne e le biomarker ea IGD.

Ho senyeha hoa taolo e tšoanang ea thibelo ho fumanoe thutong e ngoe ke Dong et al []. E le karolo ea boithuto bo hloahloa ba ho ikopanya ba mmuso, sampole ea li-IGD e entse mosebetsi oa Stroop nakong ea ha ho hlahlojoa ketsahalo ea FMRI e amanang le ketsahalo. Bangoli ba hlokometse hore nakong ea liteko tse senang 'nete, li-IGD li bonts'itse ts'ebetso e matlafalitsoeng ea li-gretus tse ka pele tse peli le ts'ebetso e fokotsehileng ea corsex ea dorsolateral pele, cortex ea orbitofrontal le cortex ea ka ntle, libaka tsohle tse amehang taolong e phahameng.

Ko et al [o sebelisitse paradigm ea ho ea / ho sa tsamaee e nang le linomoro tsa tekolo ho lekola karabo ea karabo le ts'ebetso ea liphoso ho 26 e tona ea IGDp. Bangoli ha baa ka ba fumana bofokoli bo bohlokoa ba boitšoaro ho IGDp, mabapi le NC. Ho fapana le hoo, ha ba hlahlobisisa data ea fMRI, ba tlaleha litlamorao tse kholo tsa sehlopha: Nakong ea katleho ea thibelo ea karabo, IGDp e ile ea kenya letsoho patlate ea letsoho le ho itsamaisa ka ho fetesisa ho feta ha NC; nakong ea boitlamo ba phoso ba ile ba hloleha ho kenya ts'usumetso e nepahetseng. Orbitofrontal gyrus le insula ke libaka tsa bohlokoa ho fetoleng taolo ea thibelo le phoso, ka hona bangoli ba khothalelitse hore IGDp e hloka ho hokahanya ligruse ea orbitofrontal ho etsa mosebetsi ka katleho le ho buseletsa hypofunction e kentsoeng.

Sengoliloeng sa morao tjena, Chen et al [] o sebelisitse moralo o thibelang ho hlahloba likarolo tsa tšebetso tsa taolo ea kelello ho IGDp ka mosebetsi o fokolang oa ho ea. Leha e le boitšoaro bo botle, IGDp e bonts'itse ts'ebetso e fokotsehileng ea sebaka sa makoloi se tlatsetsang / sebaka sa tlatsetso, setereke sa bohlokoa ho khethoeng boits'oaro bo nepahetseng, le ho thibela likarabo tse fosahetseng.

Liu et al [] Ngoliso ea sampole e kopaneng ea bong ba IGDp mme a sebelisa paradigm e fetotsoeng / ho se tsamaee, a kenya setšoantšo sa papali e le basomi ba morao-rao. Ba bone tšebetso e tšoanang ea sehlopha ho paradigm ea pele, empa liphoso tse ngata tsa khomishene nakong ea tšitiso ea cue ka sehlopha sa IGD. Ntle le moo, nakong ea mosebetsi oa mantlha, IGDp e ile ea fetisa mokhoa o nepahetseng oa parietal lobe, athe nakong ea papali e neng e le maemong a khathollang ba ile ba hypoactivated tokelo ya dorsolateral prefrontal cortex, le tokelo e phahameng ea parietal lobe le cerebellum. Tlhahlobo ea tikoloho e khahlisang e bontšitse hore ho IGDp tekanyo ea liphoso tsa khomishene e ne e amahanngoa hantle le ts'ebetso e nepahetseng ea dorsolateral prefrontal cortex le activation e phahameng ea parietal lobe. Bangoli ka hona ba khothalelitse hore lits'ebetso tsa libapali li amme haholo taolo ea inhibitory ho IGDp, nakong eohle ea ho sitoa hoa ts'ebetso ea dorsolateral prefrontal cortex le mosebetsi o phahameng oa parietal lobe.

Mosebetsi oa ho lemoha lintho tse ling tse ka u amang maikutlo le oa ho fifatsa lintho, o boetse oa sebelisoa ke Lorenz et al [] sehlopheng se senyenyane sa IGDp: Ba tsamaisitse liteko tse peli tsa khetho ea matšoao nakong ea liteko tse khutšoane (SP) le tlhahiso e telele (LP) ka sepheo sa ho etsa hore ho be le leeme le ho etsa lintho hape. Stimuli e ne e le lifoto tsa maikutlo tsa Machabeng tse amang maikutlo (tse sa nke lehlakore kapa tse ntle) le litšoantšo tse hlahisoang ke khomphutha (litšoantšo tse sa nke lehlakore kapa litšoantšo tse thehiloeng ho World of Warcraft videogame). IGDp e bonts'a khethollo e kholo ea tlhokomelo vs litšoantšo tse amanang le papali ka bobeli le tse amanang le papali e ntle. Ha ho bapisoa le NC, IGDp e bonts'itse ts'ebetso e sa tloaelehang ea cortex ea medial prefrontal cortex, cortex ea anterior, cortex ea orbitof mbeleal le amygdala nakong ea liteko tsa SP le tsa libaka tsa occipital, li-gyrus tse ka tlase tse ka pele le hippocampus e nepahetseng nakong ea liteko tsa LP. Maikutlong a lingoli, bakuli ba IGDp ba bonts'itse karabelo ea boitšoaro le ea tlhaho e ts'oanang le e bonoang ho bakuli ba nang le ts'ebeliso ea lithethefatsi, ba lebisa tlhokomelo e kholo ho tse susumetsang.

TŠOHLOA

Tokomaneng ena, re ile ra lekola lithuto tsa FMRI tse phomotseng le tse amanang le mosebetsi ho bakuli ba baholo ba nang le IAD. Tsena ntle le e le 'ngoe feela ea lipampiri tse kenyellelitsoeng ho litekanyetso tsa rona tsa boleng bo entsoe kontinenteng ea Asia, ho netefatsa tlhokomelo e kholo e fuoeng boemo bona bo ka bang kotsi ka mebuso ea Bochabela [].

Boholo ba lithuto li ne li etsoa ho banna ba bacha ba IGDp (ho bolela lilemo tsa ≤ 25 lilemo), ka basali ba fokolang feela le lithuto tse se nang papali ea papali ea inthanete eo e seng papali. Ho qoba litlamorao life kapa life tse mpe tsa maemo a mang, re kenyelletsa lithuto tse entsoeng feela lithutong tse se nang khatello ea kelello kapa khatello ea tšebeliso ea lithethefatsi.

Ha re akaretsa liphumano tsa lingoliloeng, re bonts'itse hore IGDp e fapane le papiso e phetseng hantle ts'ebetsong ea libaka tse 'maloa tsa boko tse kenyelletsang ts'ebetsong ea meputso le taolo ea taolo / tlhokomelo, leha e ne e le boitšoaro bo botle.

Ka ho khetheha, ka ho fetisisa e ile ea tlaleha dysfunctions cortical ne sebakeng gyrus orbitofrontal, anterior cingulate cortex, insula, dorsolateral prefrontal cortex, phahametse ya ntango gyrus, tlaasana tse tobileng gyrus, precuneus le kamorao cingulate cortex, athe ya libaka subcortical, alterations tshebetso ne ba atisa ho fumana ho brainstem le Caudate.

Orbitof Pambal cortex e ameha ho etseng liqeto, boits'oaro bo tataisoang ke boleng le kutloelo-bohloko ea kotlo [,]: Ka khokahano ea eona e mengata le libaka tsa pele, tsa maoto le tsa maikutlo, e lekanya moputso o ka bang teng oa tšusumetso e fanoeng le boits'oaro bo nepahetseng ho fihlela sephetho se nepahetseng. Ho bakuli ba lemaletseng lithethefatsi, ts'ebetso e fetotsoeng ea orbitofrontal cortex e hokahane le ho etsa liqeto le ho sitisoa ha liqeto []. Cortex ea Anterior cingrate le cortex ea insular ka bobeli li ameha ka tlhokomelo e tsitsitseng, ho shebella likhohlano, ho tšoaea phoso [le ts'ebetso ea maikutlo a seng monate []. Li fana ka sekhahla lipakeng tsa lits'ebetso tse fapaneng tsa tsoekere, li tiisa maikutlo ho isa boikutlong [,]. Ts'ebetso e fetotsoeng ea anterior cingrate cortex le insula li fumanoe bokhobeng ba joala le lithethefatsi [,].

Dorsolateral preambilial cortex ke sebaka se amehang mesebetsing e fapaneng ea kelello, joalo ka memori e sebetsang []]. Ho ile ha fumanoa ts'ebetso e sa tloaelehang ea dorsolateral preortal cortex ho batho ba noang joala haholo mabapi le lino tse tahang nakong ea mosebetsi oa ho ea / ho se na letho [] le ho ba bechang ka methapo ea methapo nakong ea mosebetsi oa ho etsa liqeto tsa cue [].

Superm grafus e phahameng e fumanoe e ts'ebetsong ts'ebetsong ea maikutlo a bonoang ka litaba tsa maikutlo [] le nakong ea mosebetsi []. Ts'ebetso e fokotsehileng ea khatello e matla ea moea oa nakoana e tlalehiloe ho batho ba lemaletseng koae nakong ea mosebetsi oa Stroop [].

Gyrus e ka tlase e ka tlase e na le karolo ho thibelleng [cognitive inhibition []], ho etsa liqeto[] le tšebetso ea maikutlo []. Ho arabela liqeto tse kenyelletsang ho hloka botsitso le nakong ea ts'ebetso e kenelletseng ea puisano, batho ba baholo ba nang le bothata ba ts'ebeliso ea koae le amphetamine ba bonts'itse ts'ebetso e fokolisitsoeng ea ts'ebetso ea boemo bo tlase mabapi le basebelisi ba pele ba matlafatsang le taolo e phetseng hantle []. The precuneus e na le karolo ea bohlokoahali ea ho itšehla thajana, litšoantšo tsa moea-pono, ho khutla ha mohopolo oa episodic [] le ho tšoaetsoa sepheo nakong ea mesebetsi e boima []. Mosebetsing oa bona ho batho ba lemaletseng marang-rang ka ho itšetleha ka comorbid nicotine, Ko et al [] e tlaleha ts'ebetso e eketsehileng ea precuneus nakong ea papali ea papali ea cue ho IGDp e kulang haholo, empa eseng ho IGDp e sa lefelloeng.

Pterior cingrate cortex e nkuoa e le karolo ea mokhoa o sa feleng oa boko [] le ho fifala ha eona nakong ea mesebetsi e mengata e hlokolosi e lemohuoa e le pontšo ea ho fallisoa ha lisebelisoa tsa ho sebetsa []. Ts'ebetso e fetotsoeng ea posterior cingrate cortex le likarolo tse ling tsa Default Mode Network e tlalehiloe ho lithethefatsi tsa koae, haholoholo ho ba nang le ts'ebeliso e sa foleng [].

Bohlokoa ba ts'ebetso ea ts'ebetso ea ts'ebetso ea kelello ho fana ka litsela tse nyolohang le tse theohileng lipakeng tsa boko le 'mele li ngotsoe hantle []. Haholo-holo, libaka tsa pele le cortex ea "anterior" li hokahane haholo le ts'ebetso ea kelello, ka hona ho se sebetse hantle ha sebopeho sena sa subcortical ho lebisa tlhokomelong le tahlelong e kholo [].

Caudate nucleus e kenella ho boemo ba morao, taolo ea makoloi le ho feto-fetoha ha mekhoa ea mokhoa oa ho ikamahanya le maemo []. Karabelo litabeng tsa joala, batho ba noang joala bo bongata ba bontšitse ts'ebetso e phahameng ka ho fetisisa mabapi le basebelisi ba itekanetseng [].

Ho nahana ka radiology ke leano le sebetsang la ho etsa lipatlisiso maemong a kelello le methapo, 'me ho ka nkuoa e le mokhoa oa "limolek'hule tsa methapo ea mafu",], sebaka sa lipatlisiso se kopaneng se etselitsoeng ho hlahloba likamano tse rarahaneng pakeng tsa liphatsa tsa lefutso, tikoloho, liphetoho tsa limolek'hule le sephetho sa nako e telele sa mathata a bophelo bo botle ba bongaka [].

Ha re kopantsoe hammoho, sephetho sa tlhahlobo ea rona ea kemiso se bontša hore motho e moholo ea nang le IGD, ntle le bothata bofe kapa bofe ba kelello, o bonts'itse mokhoa oa liphetoho tse sebetsang tšebetsong tsa boko tse ts'oanang le tse lemalloang ke ts'ebeliso ea lithethefatsi.

Ts'ebetso e fetotsoeng ea "anterior and posterior cingrate cortex, libaka tsa pele le tsa parietal, libaka tse nang le maoto le likarolo tse ikhethileng li etsa hore ho be le tšitiso e sa sitisoeng ke kutlo le kutloelo-bohloko e sa tloaelehang ea ho fana ka moputso le kotlo. Joalokaha ho hlokometsoe khatellong ea tšebeliso ea lithethefatsi, bakuli ba nang le IAD ba bonts'a ho feto-fetoha ha kelello ho felletseng, likarabo tse tsitsitseng haholoanyane le boits'oaro bo sa lokang, tse nang le litlamorao tse mpe bophelong ba bophelo le mosebetsing.-].

Meeli ea thuto

Boholo ba bakuli ba ngolisitseng lithutong tse lekiloeng e ne e le banna ba IGDp, ka hona liqeto li ke ke tsa fetisetsoa ho lingaka tse ling tsa IAD kapa ho bakuli ba basali. Ha re shebisisa maikutlo a rona lithutong tsa batho ba baholo, re ile ra kenyelletsa lithuto tsa fMRI tse entsoeng lithutong tsa bana le lilemong tsa bocha.

LITABA

Background

Boloetse ba ts'ebeliso e mpe ea inthanete (IAD) ke bothata bo laoloang ke tšusumetso bo khetholloang ke ts'ebeliso e sa laoloang ea Marang-rang, e amanang le ho senyeha hoa ts'ebetso kapa khatello ea maikutlo. Le ha e sa nkuoe e le pherekano ea kelello khatisong ea hajoale ea Diagnostic and Statistical Manual of Mental Disorders (DSM-5), ke boemo bo tsitsinyehang haholo, ka lebaka la ho ata ha bona ho teng har'a bacha le bacha ba baholo.

Meeli ea lipatlisiso

Tse ling tsa litšobotsi tsa kliniki tsa IAD, joalo ka tahlehelo ea taolo, ho lakatsa le matšoao a ho tlohela ha bakuli ba sa lumelloe ho sebelisa marang-rang li tšoana le tse bonoang ke mathata a tšebeliso ea tšebeliso ea lithethefatsi kapa lithethefatsi. Ka hona, lilemong tse fetileng lithuto tse 'maloa tsa neuroimaging li entsoe ka sepheo sa ho fuputsa kamano pakeng tsa tlhahiso ea IAD ea bongaka le ts'ebetso ea libaka tse ikemetseng le tse sa amehang ho sebetsaneng ha moputso le taolo ea kelello.

Mekhoa e metle le likhetho

Patlisiso e ncha kajeno ke mokhoa o ts'episang ho tlatsa lekhalo lipakeng tsa limolek'hule tsa mafu a kelello le lipontšo tsa tsona tsa bongaka. Lingoliloeng tsa mahlale tse mabapi le tlhahlobo ea liphatlalatso tse kang IAD li ntse li eketseha ka potlako, ka hona ho fana ka tlhahlobo e ntlafalitsoeng ea tlhaiso-leseling ea ho qetela e ka khahlisa babali. Ho shebisisa tlhahlobo e hlophisehileng ea bangoli ka disampole tse sa lefelloeng tsa thuto (bakuli ba baholo feela, ha ho maemo a kelello a lumelloang a kelello a lumelletsoeng) liphetho tsa lipatlisiso tse fapaneng li ka bapisoa habonolo le ho fumana ho tšoana le ho se utloane.

dikopo

Boemong ba kliniki, bakuli ba nang le boemo bo tšoanang ba kelello ba kelello hangata ba fapana ho ea ka matšoao a kliniki, karabelo ho kalafo ea meriana le sephetho sa nako e telele. Ho ithuta ka kelello le boits'oaro ba bona ka lintlha ho ka thusa ho fana ka tlhahlobo le kalafo e nepahetseng haholoanyane.

Terminology

IAD: Bofokoli bo laolang tšusumetso bo khetholloang ke tšebeliso e sa laoloeng ea Marang-rang, e amanang le ho senyeha hoa ts'ebetso kapa khatello ea maikutlo; IGD: Tlhaku e tlase ea IAD, eo hape e bitsoang bokhoba ba videogame, e khetholloang ka papali e ngata ea inthanete e le ts'ebetso ea mantlha ea inthanete.

Tlhahlobo-leseling

Ena ke sengoloa se khahlisang haholo.

Mongolo o botlaaseng ba leqephe

 

E tšehelitsoe ke Lefapha la Neuroscience, Imaging, le Saense ea Tleliniki, Univesithi "G.d'Annunzio", Chieti, Italy; Thuso ea Dr. Sepede ea hoc ea tšebetso e tšehelitsoe ke Lenaneo la Boraro-bo-bong la European Union bakeng sa lipatlisiso, nts'etsopele ea mahlale le ponts'o tlasa tumellano ea tumello, Che. 602450.

 

 

Polelo ea qhoebeshano: "Bangoli bohle ha ba tlalehe pherekano ea phaello. Pampiri ena e bonts'a maikutlo a bangoli feela mme European Union ha e na boikarabello bakeng sa ts'ebeliso efe kapa efe e ka 'nang ea etsoa ka tlhahisoleseling e fumanehang ho eona.

 

 

Polelo ea ho arolelana data: Ha ho na lintlha tse eketsehileng tse fumanehang.

 

 

Phumano e Bulehileng: Sengoliloeng sena ke sengoloa se bulehileng se khethiloeng ke mohlophisi oa kahare mme se hlahlojoe ka botlalo ke bahlahlobisisi ba kantle. E ajoa ho latela lengolo la tumellano la Creative Commons Attribution Non Commerce (CC BY-NC 4.0), e lumellang ba bang ho e aba, ho lokisa, ho feto-fetoha le maemo, ho aha ka mosebetsi ona e seng oa khoebo, le laesense ea mesebetsi ea bona e tsoang ka mantsoe a fapaneng. Mosebetsi oa mantlha o qotsitsoe ka nepo mme ts'ebeliso ha e rekisoe. Bona: http://creativecommons.org/licenses/by-nc/4.0/

 

 

Tlhahlobo ea lithaka e qalile: Phupu ea 30, 2015

 

 

Qeto ea pele: Mphalane 30, 2015

 

 

Sengoloa ka khatiso: December 21, 2015

 

 

Mohlophisi oa lintlha: Gumustas OG, Matsumoto S S- Sehloekisi: Ji FF L- Sehloekisi: Mohlophisi oa E: Liu SQ

 

References

1. Mocha KS. Tlatsetso ea inthanete: ho hlaha ha bokuli bo bocha ba kliniki. Cyberpsychol Behav 1998; 1: 237-244.
2. American Psychiatric Association (APA) Diagnostic le buka ea tataiso ea lipalo tsa mathata a kelello (5th ed). Washington, DC, 2013. E fumaneha ho: http://www.psychiatry.org/
3. Cheng C, Li AY. Keketseho ea inthanete le boleng ba bophelo (ba sebele): tlhahlobo ea meta ea lichaba tsa 31 libakeng tse supileng tsa lefatše. Cyberpsychol Behav Soc Netw. 2014; 17: 755-760. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
4. Krishnamurthy S, Chetlapalli SK. Tlhahiso ea inthanete: Ho ba haufi le maemo a kotsi: Thutong ea boithuto ho baithuti ba kolecheng ea Bengaluru, Silicon Valley ea India. Bophelo bo Botle ba Indian J. 2015; 59: 115-121. [E fetotsoe]
5. Rumpf HJ, Vermulst AA, Bischof A, Kastirke N, Gürtler D, Bischof G, Meerkerk GJ, John U, Meyer C. Ts'ebetso ea ts'ebeliso ea ts'ebeliso ea marang-rang molemong oa bongata ba tlhahlobo: tlhahlobo ea sehlopha sa morao-rao. Khokahano ea Res. 2014; 20: 159-166. [E fetotsoe]
6. Choi SW, Kim HS, Kim GY, Jeon Y, Park SM, Lee JY, Jung HY, Sohn BK, Choi JS, Kim DJ. Ho ts'oana le ho se tšoane lipakeng tsa sebapali sa marang-rang sa marang-rang, bothata ba papali ea chelete le bothata ba tšebeliso ea joala: sepheo sa ho susumetsoa le ho qobelloa. J Behav Moemeli. 2014; 3: 246-253. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
7. Bipeta R, Yerramilli SS, Karredla AR, Gopinath S. Ts'oaetso ea Khatello ea Phallo ea Inthanete Tlas'a Tlhaloso e Tlamang: Lintlha tse tsoang Thutong ea Phekolo ea Tlhaho ea selemo se le seng. Innov Clin Neurosci. 2015; 12: 14-23. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
8. Wölfling K, Beutel ME, Dreier M, Müller KW. Boloetse ba sefahleho sa Bipolar ho sampole ea bakuli ba lemaletseng ts'ebeliso ea marang-rang: li-comorbidity tse patiloeng kapa tlhahlobo e khethollang? J Behav Moemeli. 2015; 4: 101-105. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
9. Tonioni F, Mazza M, Autullo G, Cappelluti R, Catalano V, Marano G, Fiumana V, Moschetti C, Alimonti F, Luciani M, et al. Na bokhoba ba marang-rang ke boemo ba kelello bo fapane hole le papali ea chelete ea methapo? Moemeli oa Behav. 2014; 39: 1052-1056. [E fetotsoe]
10. Walton E, Turner JA, Ehrlich S. Neuroimaging e le mohoebi ea nang le monyetla oa ho hlahisa lipatlisiso tsa kalafo le kalafo ea kelello. Int Rev Psychiatry. 2013; 25: 619-631. [E fetotsoe]
11. Bullmore E. Bokamoso ba MRI bo sebetsang ka meriana ea bongaka. Neuroimage. 2012; 62: 1267-1271. [E fetotsoe]
12. Mitterschiffthaler MT, Ettinger U, Mehta MA, Mataix-Cols D, Williams SC. Likopo tsa ts'ebetso ea ho nahana ka matla a matla a khoheli a sebelisang matla a kelello. J Magn Reson Imaging 2006; 23: 851-861. [E fetotsoe]
13. van den Heuvel MP, Hulshoff Pol HE. Ho hlahloba marang-rang a boko: tlhahlobo mabapi le kgokahano e sebetsang ea fMRI ea tšebetso. Eur Neuropsychopharmacol. 2010; 20: 519-534. [E fetotsoe]
14. Sava S, Yurgelun-Todd DA. Ts'ebetso ea matla a khoheli a sebetsang ho ts'ebetso ea kelello. Maemo a Holimo a Magn Reson. 2008; 19: 71-79. [E fetotsoe]
15. Greicius M. Khokahanyo ea tšebetsong ea mmuso maemong a methapo ea methapo ea methapo. Curr Opin Neurol. 2008; 21: 424-430. [E fetotsoe]
16. Lerata la mahe a linotsi, PC ea Fletcher, Bullmore ET. Ts'ebetso ea 'mapa o sebetsang oa psychopathology. J Neurol Neurosurg Psychiatry. 2002; 72: 432-439. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
17. Ko CH, Liu GC, Hsiao S, Yen JY, Yang MJ, Lin WC, Yen CF, Chen CS. Mesebetsi ea brain e amanang le takatso ea papali ea ho lemalla papali ea chelete Inthaneteng. J Psychiatr Res. 2009; 43: 739-747. [E fetotsoe]
18. Liu J, Gao XP, Osunde I, Li X, Zhou SK, Zheng HR, Li LJ. Ho eketsa homogeneity ea tikoloho bothateng ba ho lemalla ts'ebeliso ea marang-rang: thuto ea ho nahanisisa ea mmuso e sebetsang. Chin Med J (Engl) 2010; 123: 1904-1908. [E fetotsoe]
19. Han DH, Hwang JW, Renshaw PF. Phekolo e sa tsitsang ea Bupropion e fokotsa ho labalabela lipapali tsa video le ts'ebetso ea bongoana e kenyellelitsoeng ho bakuli ba lemaletseng papali ea video ea inthanete. Clin Psychopharmacol. 2010; 18: 297-304. [E fetotsoe]
20. Dong G, Huang J, Du X. Matlafatso a tefiso ea moputso le ho fokotsa maikutlo a tahlehelo ho lithahasello tsa marang-rang: thuto ea fMRI nakong ea mosebetsi oa ho hakanya. J Psychiatr Res. 2011; 45: 1525-1529. [E fetotsoe]
21. Dong G, Huang J, Du X. Liphetoho ho homogeneity ea tikoloho ea ts'ebetso ea kelello ea phomolo ea mmuso ho lithethefatsi tsa lipapali tsa marang-rang. Behav Brain Funct. 2012; 8: 41. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
22. Dong G, Devito EE, Du X, Cui Z. Ho sitisoe taolo ea inhibitory ho "internet addiction disorder": ts'ebetso ea ho nahana ka matla a maqhubu a matla a matla a marang-rang. Psychiatry Res. 2012; 203: 153-158. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
23. Lorenz RC, Krüger JK, Neumann B, Schott BH, Kaufmann C, Heinz A, Wüstenberg T. Cue reactivity le tšitiso ea eona ho libapali tsa lipapali tsa khomphutha tsa pathological. Adict Biol. 2013; 18: 134-146. [E fetotsoe]
24. Dong G, Shen Y, Huang J, Du X. Ho senyeha ha ts'ebetso ea ho lekola phoso ho batho ba nang le bothata ba ho lemalla Inthanete: thuto e amanang le fMRI e amanang le ketsahalo. Khokahano ea Res. 2013; 19: 269-275. [E fetotsoe]
25. Dong G, Hu Y, Lin X, Lu Q. Ke eng e etsang hore bokhoba ba marang-rang ba tsoele pele ho bapala marang-rang leha ba tobane le litlamorao tse mpe? Litlhaloso tse ka bang teng ho tsoa thutong ea fMRI. Psychol ea Biol. 2013; 94: 282-289. [E fetotsoe]
26. Dong G, Hu Y, Lin X. Moputso / maikutlo a kotlo har'a lithahasello tsa marang-rang: Liphetoho bakeng sa boits'oaro ba bona ba tlhekefetso. Prog Neuropsychopharmacol Biol Psychiatry. 2013; 46: 139-145. [E fetotsoe]
27. Dong G, Lin X, Zhou H, Lu Q. Ho feto-fetoha le maemo ha bokhoba ba marang-rang: bopaki ba fMRI ho tloha maemong a bonolo le a bonolo a ho fetoha. Moemeli oa Behav. 2014; 39: 677-683. [E fetotsoe]
28. Ko CH, Hsieh TJ, Chen CY, Yen CF, Chen CS, Yen JY, Wang PW, Liu GC. Ts'ebetso e fetotsoeng ea ts'ebetso ea ts'ebetso ea ts'ebetso nakong ea ts'ibollo le karabelo ea liphoso lithutong tse nang le bothata ba lipapali tsa inthanete: thuto ea maiketsetso e sebetsang. Clin Neurosci ea Arch Psychiatry. 2014; 264: 661-672. [E fetotsoe]
29. Liu GC, Yen JY, Chen CY, Yen CF, Chen CS, Lin WC, Ko CH. Brain activation bakeng sa karabo ea karabelo tlasa tšitiso ea lipapali tsa papali ea litaba tsa lipapali tsa inthanete. Kaohsiung J Med Sci. 2014; 30: 43-51. [E fetotsoe]
30. Chen CY, Huang MF, Yen JY, Chen CS, Liu GC, Yen CF, Ko CH. Bont correlates of reaction inhibition ho Internet lipapali tsa bohloka. Psinchiatry Clin Neurosci. 2015; 69: 201-209. [E fetotsoe]
31. Dong G, Lin X, Potenza MN. Khokahanyo e sebetsang ea marangrang ho netweke ea taolo e phahameng e amana le ts'ebetso e mpe ea ts'ebetso ea taolo ea lipapali tsa inthanete. Prog Neuropsychopharmacol Biol Psychiatry. 2015; 57: 76-85. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
32. Kim H, Kim YK, Gwak AR, Lim JA, Lee JY, Jung HY, Sohn BK, Choi SW, Kim DJ, Choi JS. Homogeneity ea phomolo-ea mmuso e le lets'oao la likokoana-hloko bakeng sa bakuli ba nang le bothata ba lipapali tsa inthanete: Papiso le bakuli ba nang le bothata ba tšebeliso ea joala le taolo e phetseng hantle. Prog Neuropsychopharmacol Biol Psychiatry. 2015; 60: 104-111. [E fetotsoe]
33. Liu J, Li W, Zhou S, Zhang L, Wang Z, Zhang Y, Jiang Y, Li L. Mekhoa e sebetsang ea boko ho baithuti ba koleche ba nang le bothata ba lipapali tsa marang-rang. Ho Behav Brain 2015: Epub pele e hatisoa. [E fetotsoe]
34. Zhang JT, Yao YW, Li CS, Zang YF, Shen ZJ, Liu L, Wang LJ, Liu B, Fang XY. Boemo bo fetoletsoeng ba mmuso ba ho ikopanya ha mosebetsi oa ho kenella ho batho ba baholo ba nang le bothata ba lipapali tsa inthanete. Adict Biol. 2015: Epub pele e hatisoa. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
35. Beard KW, Wolf EM. Phetoho mehatong e reriloeng ea tlhahlobo ea ho lemalla tahi ea inthanete. Cyberpsychol Behav. 2001; 4: 377-383. [E fetotsoe]
36. Ko CH, Yen JY, Chen SH, Yang MJ, Lin HC, Yen CF. Mekhoa e reriloeng ea tlhahlobo ea mali le sesebelisoa sa tlhahlobo le tlhaiso sa tlhekefetso ea inthanete ho baithuti ba koleche. Compr Psychiatry. 2009; 50: 378-384. [E fetotsoe]
37. Wang WZ, Tao R, Niu YJ, Chen Q, Jia J, Wang XL, Kong QM, Tian CH. Litekanyetso tsa pele tsa tlhahlobo ea tšebeliso ea ts'ebeliso ea marang-rang. Bophelo bo botle ba Mental China "X 2009; 23: 890e4.
38. Grüsser SM, Thalemann CN. Verhaltenssucht: Diagnostik, Therapies, Forschung. Bern: Huber; 2006.
39. Frank IH. Ho lakatsa lithethefatsi le ho lemalla: ho kopanya mekhoa ea kelello le neuropsychopharmacological. Prog Neuropsychopharmacol Biol Psychiatry. 2003; 27: 563-579. [E fetotsoe]
40. Wilson SJ, Sayette MA, Fiez JA. Likarabo tsa pele ho lithahasello tsa lithethefatsi: tlhahlobo ea methapo ea kutlo. Nat Neurosci. 2004; 7: 211-214. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
41. Reuter J, Raedler T, Rose M, Hand I, Gläscher J, Büchel C. Ho bapala papali ea chelete ho amana le ts'ebetso e fokotsitsoeng ea sisteme ea moputso oa mesolimbic. Nat Neurosci. 2005; 8: 147-148. [E fetotsoe]
42. MacLeod CM. Halofo ea lilemo tse lekholo ea lipatlisiso ka phello ea Stroop: tlhahlobo e kopanyang. Psychol Bull. 1991; 109: 163-203. [E fetotsoe]
43. Stroop JR. Boithuto ba ho kena-kenana le liphihlelo tsa serial tsa polelo. J Exp Psychol. 1935; 18: 643-662.
44. Hester R, Fassbender C, Garavan H. Ho fapana ha motho ho sebetsanang le liphoso: tlhahlobo le boithuto ba lithuto tse tharo tse amanang le ketsahalo tsa FMRI tse sebelisang mosebetsi oa GO / NOGO. Cereb Cortex. 2004; 14: 986-994. [E fetotsoe]
45. Bradley B, Field M, Mogg K, De Houwer J. Tlhokomeliso le khethollo ea litlolo bakeng sa ts'ebeliso ea ho tsuba ho itšetlehileng ka nicotine: lits'ebetso tsa likarolo tsa khethollo ea maikutlo. Behav Pharmacol. 2004; 15: 29-36. [E fetotsoe]
46. MacLeod C, Mathews A, Tata P. Tlhokomeliso ea leeme bothateng ba maikutlo. J Abnorm Psychol. 1986; 95: 15-20. [E fetotsoe]
47. Castell X, Casas M, Pérez-Mañá C, Roncero C, Vidal X, Capellà D. Ho sebetsa ha lithethefatsi tsa psychostimulant bakeng sa ts'ehetso ea koae. Database ea Cochrane Syst Rev. 2010; (2): CD007380. [E fetotsoe]
48. Sepede G, Di lorio G, Lupi M, Sarchione F, Acciavatti T, Fiori F, Santacroce R, Martinotti G, Gambi F, Di Giannantonio M. Bupropion e le tlatsetso ho phekolo ea khatello ea maikutlo ea ho ferekana kelellong e bakang bakuli ba nang le ts'ehetso ea koae ea koae. . Clin Neuropharmacol. 2014; 37: 17-21. [E fetotsoe]
49. Dannon PN, Lowengrub K, Musin E, Gonopolski Y, Kotler M. Ho ts'epahala-ho lokolla lupropion khahlanong le naltrexone ts'ebetsong ea ts'ebetso ea ho becha ka ts'ebeliso ea methapo: thuto ea pele ea sefofane sa mahlo. J Clin Psychopharmacol. 2005; 25: 593-596. [E fetotsoe]
50. Ahn DH. Leano la Korea mabapi le kalafo le ntlafatso ea bokhoba ba marang-rang ba bacha ho 2007 International Symposium mabapi le Tlhabollo le Phekolo ea Bacha ba Lemaletseng Inthanete. Seoul, Korea, Khomishene ea Naha ea Bacha: 2007. leq. 49.
51. Rangel A, Camerer C, Montague PR. Moralo oa ho ithuta neurobiology ea ho etsa liqeto tse thehiloeng holim'a boleng. Nat Rev Neurosci. 2008; 9: 545-556. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
52. Rolls ET, Grabenhorst F. The cortex ea orbitofrontal le ka nqane: ho tloha ho ama ho nka qeto. Prog Neurobiol. 2008; 86: 216-244. [E fetotsoe]
53. London ED, Ernst M, Grant S, Bonson K, Weinstein A. Orbitofrontal cortex le ts'ebeliso e mpe ea lithethefatsi tsa batho: monahano o sebetsang. Cereb Cortex. 2000; 10: 334-342. [E fetotsoe]
54. Bush G, Luu P, Posner MI. Tšusumetso ea maikutlo le ea maikutlo ho anterior cingrate cortex. Trends Cogn Sci. 2000; 4: 215-222. [E fetotsoe]
55. Petrovic P, Pleger B, Seymour B, Klöppel S, De Martino B, Critchley H, Dolan RJ. Ho thibela tšebetso ea opiate e bohareng ho fetola tšusumetso ea hedonic le karabelo ea cingate ea anterior ho moputso le tahlehelo. J Neurosci. 2008; 28: 10509-10516. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
56. Kühn S, Gallinat J. Biology e tloaelehileng ea ho lakatsa lithethefatsi tse seng molaong le tse seng molaong - tlhatlhobo e ngata ea karabelo ea ts'ebetso ea boko. Eur J Neurosci. 2011; 33: 1318-1326. [E fetotsoe]
57. Kurth F, Zilles K, Fox PT, Laird AR, Eickhoff SB. Khokahano pakeng tsa lits'ebetso: phapang e sebetsang le kopanyo kahare ho ts'ebetso ea motho e senotsoeng ke tlhahlobo ea meta. Sebaka sa Bolulo ea Brain. 2010; 214: 519-534. [E fetotsoe]
58. Goldstein RZ, Volkow ND. Bokhoba ba lithethefatsi le motheo oa eona oa motheo oa neurobiological: Bopaki ba neuroimaging ba ho kenya letsoho mokokotlong oa pele. Ke J Psychiatry. 2002; 159: 1642-1652. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
59. Schacht JP, Anton RF, Myrick H. Lipatlisiso tse sebetsang tsa ho ithuisa ka tšebeliso ea lino tse tahang: tlhahlobo-leseling ea meta le tlhahlobo e hlophisitsoeng. Adict Biol. 2013; 18: 121-133. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
60. Petrides M. Karolo ea "cortex" e bohareng ea dorsolateral prefrontal in memory memory. Brain Res. 2000; 133: 44-54. [E fetotsoe]
61. Seidler RD, Bo J, Anguera JA. Menehelo e mabapi le boithuto ba thuto ea boithuto ba motlakase: karolo ea memori e sebetsang. J Mot Behav. 2012; 44: 445-453. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
62. Ames SL, Wong SW, Bechara A, Cappelli C, Dust M, Grenard JL, Stacy AW. Litlatsetso tsa Neural tsa mosebetsi oa Go / NoGo le ts'usumetso ea joala ka bobebe le banyane ba noang haholo. Behav Brain Res 2014; 274: 382-389. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
63. Crockford DN, Goodyear B, Edward J, Quickfall J, el-Guebaly N. Cue-o ile a etsa ts'ebetso ea ts'ebetso ea boko ho bataki ba methapo. Psychology ea Biol. 2005; 58: 787-795. [E fetotsoe]
64. Robins DL, Hunyadi E, Schultz RT. Ts'usumetso e phahameng ea nakoana bakeng sa ts'usumetso ea maikutlo a matla a pono-a mamelo. Kelello ea Brain. 2009; 69: 269-278. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
65. Buchsbaum BR, Greer S, Chang WL, Berman KF. Tlhahlobo-leseling ea lithuto tsa neuroimaging tsa mosebetsi oa ho hlophisa likarete le Wisconsin le lits'ebetso tsa karolo. Hum Brain Mapp. 2005; 25: 35-45. [E fetotsoe]
66. Barrós-Loscertales A, Bustamante JC, Ventura-Campos N, Llopis JJ, Parcet MA, Avila C. Ts'ebetso e tlase tlase marang-rang a nepahetseng a pele nakong ea ho bala mosebetsi oa Stroop sehlopheng se itšetlehileng ka koae. Psychiatry Res. 2011; 194: 111-118. [E fetotsoe]
67. Aron AR, Robbins TW, Poldrack RA. Thibelo le cortex e nepahetseng e ka tlase e nepahetseng. Trends Cogn Sci. 2004; 8: 170-177. [E fetotsoe]
68. Mstrong D, Corbetta M, Perrucci MG, Romani GL, Del Gratta C. Kholo e kholo ea marang-rang a ts'ebetso ea ts'ebetso ea ts'ebetso le ts'ebetso ea nakoana nakong ea tlhahlobo ea sepheo. Neuroimage. 2009; 44: 265-274. [E fetotsoe]
69. Reckless GE, Ousdal OT, Server A, Walter H, Andreassen OA, Jensen J. Gigus ea morao-rao e tlohelehileng e kenelletse ho lokisa leeme nakong ea ho etsa liqeto tse hlakileng. Brain Behav. 2014; 4: 398-407. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
70. Frühholz S, Grandjean D. Ho sebetsanang le melumo ea maikutlo ho karolo e ka tlase e ka pele ea cortex. Neurosci Biobehav Rev. 2013; 37: 2847-2855. [E fetotsoe]
71. Stewart JL, Parnass JM, May AC, Davenport PW, Paulus MP. Phetoho e fetohileng ea ts'ebetso ea ts'ebetso nakong ea ts'ebetso e kopanetsoeng ea ho kena lipakeng tsa batho ba baholo e fetoloang ho ts'ebeliso ea mathata e matlafatsang. Front Syst Neurosci. 2013; 7: 89. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
72. Cavanna AE, Trimble MR. The precuneus: Tlhahlobo ea ts'ebetso ea ts'ebetso ea "anatomy" ea hae le litloaelo tsa boitšoaro. Boko. 2006; 129: 564-583. [E fetotsoe]
73. Astafiev SV, Shulman GL, Stanley CM, Snyder AZ, Van Essen DC, Corbetta M. Ts'ebetso ea mokhatlo oa ts'ebetso ea batho ba kenang kahare le kotlo ea pele bakeng sa ho ba teng, ho sheba, le ho supa. J Neurosci. 2003; 23: 4689-4699. [E fetotsoe]
74. Ko CH, Liu GC, Yen JY, Chen CY, Yen CF, Chen CS. Litlatsetso tsa likelello tsa litakatso tsa papali ea inthanete tlasa ho pepeseha hoa lithuto tsa inthanete litabeng tsa ho lemalla papali ea inthanete le lithutong tse sa lefelloeng. Adict Biol. 2013; 18: 559-569. [E fetotsoe]
75. Fransson P, Marrelec G. Cortex ea precuneus / posterior e bapala karolo ea bohlokoa ho marang-rang a mode default: Bopaki bo tsoang tlhahlobisong ea marangrang a karolo e itseng. Neuroimage. 2008; 42: 1178-1184. [E fetotsoe]
76. McKiernan KA, Kaufman JN, Kucera-Thompson J, Binder JR. Tlhahiso-leseling ea lintlha tse amang ts'ebetso e fokolisitsoeng ea mosebetsi ho li-neuroimaging tse sebetsang. J Cogn Neurosci. 2003; 15: 394-408. [E fetotsoe]
77. Konova AB, Moeller SJ, Tomasi D, Goldstein RZ. Litlamorao tsa tse matlafatsang le tse matlafatsang tsa tšebetso ea bokaholimo bo sebetsang. Brain Res. 2015; 1628: 147-156. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
78. Angeles Fernández-Gil M, Palacios-Bote R, Leo-Barahona M, Mora-Encinas JP. Boiketlo ba kelello: Ho shebella kutu ea bophelo. Semin Ultrasound CT MR. 2010; 31: 196-219. [E fetotsoe]
79. Hurley RA, Flashman LA, Chow TW, Taber KH. The brainstem: anatomy, tekolo, le syndromes ea bongaka. J Neuropsychiatry Clin Neurosci. 2010; 22: iv, 1-7. [E fetotsoe]
80. Villablanca JR. Hobaneng re na le "caudate nucleus"? Acta Neurobiol Exp (Lintoa) 2010; 70: 95-105. [E fetotsoe]
81. Dager AD, Anderson BM, Rosen R, Khadka S, Sawyer B, Jiantonio-Kelly RE, Austad CS, Raskin SA, Tennen H, Wood RM, et al. Karabelo ea ts'ebetso ea matla a matla a matla a matla a matla a kelello (fMRI) litšoantšong tsa joala e bolela phetoho ea kamorao ho ho nwa haholo ho baithuti ba koleche. Ho lemalla. 2014; 109: 585-595. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
82. Ogino S, Chan AT, Fuchs CS, Giovannucci E. Molekhule oa methapo ea mafu ea methapo ea methapo ea mafu a mokokotlo oa colorectal neoplasia: tšimo e ntseng e hlaha ea transdisciplinary le interdisciplinary. Gut. 2011; 60: 397-411. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
83. Nishi A, Kawachi I, Koenen KC, Wu K, Nishihara R, Ogino S. Lifecourse epidemiology le molek'hule ea lefu la sethoathoa. Ke J Prev Med. 2015; 48: 116-119. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
84. Ogino S, Lochhead P, Chan AT, Nishihara R, Cho E, Wolpin BM, Meyerhardt JA, Meissner A, Schernhammer ES, Fuchs CS, et al. Molekhule oa lefu la thuto ea methapo ea kutlo ea li-epigenetics: saense e hokahaneng e hlahang ho sekaseka tikoloho, moamoheli le maloetse. Mod Pathol. 2013; 26: 465-484. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
85. Lundqvist T. Ho etsa liphoso tsa kelello tsa ts'ebeliso e mpe ea lithethefatsi. Curr Top Behav Neurosci. 2010; 3: 247-275. [E fetotsoe]
86. Luijten M, Machielsen MW, Veltman DJ, Hester R, de Haan L, Franken IH. Tlhahlobo e hlophisehileng ea lithuto tsa ERP le fMRI tse etsang lipatlisiso taolong ea inhibitory le ts'ebetso ea liphoso ho batho ba nang le ts'ebeliso ea litheko le bokhoba ba boits'oaro. J Psychiatry Neurosci. 2014; 39: 149-169. [Tlhahiso ea mahala ea PMC] [E fetotsoe]
87. Zhu Y, Zhang H, Tian M. Mole mole le ts'ebetso ea ho nahana ka lithethefatsi tsa inthanete. Biomed Res Int. 2015; 2015: 378675. [Tlhahiso ea mahala ea PMC] [E fetotsoe]