BMC Psychiatry. 2018 Dec 20;18(1):396. doi: 10.1186/s12888-018-1974-6.
Park J1, Sung JY2, Kim DK2, ID ea Kong3, Hughes TL4, Kim N5.
inahaneloang
LITLHAHISO:
Palo ea batho ba nang le lithethefatsi tsa papali ea inthanete (IGA) e ntse e eketseha ho potoloha le lefatše. IGA e tsejoa e amahanngoa le litšobotsi tsa botho, mabaka a kelello le maemo a mmele. Leha ho le joalo, ke lithuto tse fokolang feela tse hlahlobileng mabaka a lefutso a amanang le IGA. Phuputso ena e ne e ikemiselitse ho batlisisa kamano lipakeng tsa IGA le mefuta e fapaneng ea liphatsa tsa lefutso e amanang le khatello ea maikutlo.
LITLHAHISO:
Boithuto bona bo fapaneng bo entsoe le baithuti ba banna ba 230 ba sekolo se phahameng toropong ea Korea Boroa. Re khethile liphatsa tsa lefutso tse hlano tse amanang le khatello ea maikutlo: DAT1, DRD4, NET8, CHRNA4, le CRHR1. Liphatsa tsa lefutso tsa DAT1 le DRD4 li ne li entsoe ka genotyped ke polymerase chain reaction, 'me liphatsa tsa lefutso tsa NET8, CHRNA4, le CRHR1 li ne li entsoe genotyped ka pyrosequencing analysis. Re entse tlhahlobo ea sekwere sa Chi ho lekola kamano ea liphatsa tsena tsa lefutso tse hlano le IGA.
LIKOTSO:
Ho ba le genotype ea AA le mofuta oa A oa mofuta oa CRHR1 (rs28364027) ho ne ho amahanngoa le maemo a phahameng a ho ba karolo ea sehlopha sa bankakarolo ba IGA (p = .016 le p = .021, ka ho latellana) ho feta sehlopha se seng sa IGA. Ka lehlakoreng le leng, li-polymorphism tsa lefutso tsa DAT1, DRD4, NET8, le CHRNA4 ha li bontše phapang e kholo lipakeng tsa sehlopha sa IGA le sehlopha sa taolo.
CONCLUSIONS:
Liphetho tsena li bonts'a hore polymorphism ea mofuta oa CRHR1 e ka bapala karolo ea bohlokoa ho ts'oaetsong ha IGA ho palo ea banna ba lilemong tsa bocha ba Korea. Liphumano tsena li fana ka mabaka le motheo oa lipatlisiso tse ling tsa liphatsa tsa lefutso tse amanang le IGA.
LITLHAKU TSE KHOLO: CRHR1; Gene polymorphism; Ho lemalla lipapali tsa inthanete
PMID: 30572854
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