Front Psychiatry. 2018 Apr 10; 9: 125. Doi: 10.3389 / fpsyt.2018.00125. eCollection 2018.
Hong JS1, Kim SM1, Bae S2, Han DH1.
1 Lefapha la Psychiatry, Sepetlele sa Chung-Ang University, Seoul, Korea Boroa.
Motheo oa Ts'ebelisano ea Liindasteri tsa 2 Viwanda, Univesithi ea Chung-Ang, Seoul, Korea Boroa.
inahaneloang
Ho bapala lipapali tsa marang-rang tse nang le bothata hangata ho tsamaisana le khatello e kholo ea khatello ea maikutlo (MDD). Ho sithabela maikutlo ho bonahala ho amana haufi le khokahano e fetoletsoeng e sebetsang (FC) kahare ho (le pakeng tsa) netweke ea mode default (DMN) le network ea salience. Ntle le moo, serotonergic neurotransication e ka laola matšoao a khatello ea maikutlo, ho kenyelletsa ho ts'oaroa, ho ka khonehang ka ho fetolela DMN. Re ile ra nahana hore likamano tse fetohileng pakeng tsa khokahano ea DMN le sethala li ka kopanya kopano pakeng tsa mofuta oa 5HTTLPR genotype le ho hloka thuso ho bakuli ba nang le khatello ea maikutlo. Kakaretso ea barupeluoa ba 54 ba nang le bothata ba ho bapala papali ea inthanete mme MDD e phethe protocol ea lipatlisiso. Re entse tlhahlobo ea 5HTTLPR mme ra lekola DMN FC re sebelisa monahano oa naha oa ho phomola. Botebo ba papali ea papali ea inthanete, matšoao a sithabetsang, ho tšoenyeha, tlhokomelo le ho qobelloa, le boitšoaro bo thibelang le ts'ebetso li ile tsa hlahlojoa ho sebelisoa Internet Internet Addiction Scale (YIAS), Beck Depression Inventory, Beck Anxcare Inventory (BAI), Korea Attention Deficit Hyperacaction Disorder wadogo , le Sekala sa Behaeveal Inhibition and Activation Scale (BIS-BAS), ka ho latellana. SS allele e ne e amahanngoa le FC e neng e ntse e eketseha ka har'a DMN, ho kenyelletsa "cortex" (MPFC) e ka pele ho posterior cingxe cortex, le kaharepeng ea salience, ho kenyelletsa le "supramarginal gyrus" (SMG) ho le letona le ka pele le kaholimo. tokelo ea anterior insular (AInsular) ho le letona la SMG, anterior cingrate cortex (ACC) ho le letšehali RPFC, mme o tlohetse AInsular ho le letona RPFC, le lipakeng tsa DMN le network ea salience, ho kenyeletsoa MPFC ho ea ACC. Ntle le moo, FC ho tloha MPFC ho ea ho ACC e amana hantle le lintlha tsa BIS le YIAS sehlopheng sa SS allele. SS allele ea 5HTTLPR e ka 'na ea fetisa FC kahare le pakeng tsa DMN le sethala sa salience, tseo qetellong e ka bang sesosa sa ho bapala papali ea Inthanete ho bakuli ba MDD.
LINKOTSO:
Bothata ba lipapali tsa inthanete; mofuta oa kamehla oa marang-rang; bokuli bo boholo ba khatello ea maikutlo; marang-rang a masapo; serotonin transporter gene
PMID: 29692741
PMCID: PMC5902486
DOI: 10.3389 / fpsyt.2018.00125
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