J Nerv Ment Dis. 2018 Aug;206(8):644-656. doi: 10.1097/NMD.0000000000000861.
Caldiroli A1, Serati M, Buoli M.
inahaneloang
Morero oa kakaretso oa tlhahlobo ena ke ho hlahisa lingoliloeng tse nchafalitsoeng tsa li-neurobiological / litliniki tsa lithethefatsi tsa Inthanete (IA), haholo-holo ea ho tlōla le ho fapana le lefu la ho ferekana ha maikutlo a bipolar (BPAD). Lihlooho tse nang le litsebi tsa IA kapa litšebelisano / liphapang le BPAD e le lihlooho tse kholo, ho tloha 1990 ho tla le ho ngoloa ka Senyesemane, li kenyelelitsoe. Tlhekefetso pakeng tsa IA le mathata a mang a kelello, ho akarelletsa le BPAD, a tloaelehile. Dysfunctions dopaminergic litsela li fumanoe ka bobeli ho IA le mathata a mehopolo. Boholo ba lipatlisiso ka IA bo tšehetsa boemo bo sa sebetsaneng ba hypodopaminergic bo sa sebetseng boemong ba potoloho ea boko le boiphihlelo bo feteletseng ba moputso nakong ea ho phahama ha maikutlo. Liphuputso tse nang le mekhoa ea boipheliso li bontša boemong bo sa tloaelehang ba prefrontal cortex e arolelanoeng le bakuli ba nang le lithethefatsi le ba ferekanyang maikutlo. BPAD le IA li na le mekhoa e mengata ea ho koaloa, tse kang li-polymorphisms liphatsa tsa lefutso tsa nicotinic, likarolo tse sa tloaelehang tsa likorate / prefrontal, li-dotfunction tsa serotonin / dopamine, le karabelo e ntle ho li-stabilizers. Bokamoso ke ho hlakisa litekanyetso tsa ho hlahloba ho hlalosa hantle kamano ea IA / BPAD.
PMID: 30028359
;