Tšebeliso ea Inthanete ka bothata: ho hlahloba mekhatlo pakeng tsa ho utloisisa le COMT rs4818, rs4680 haplotypes.

CNS Spectr. 2019 Jun 4: 1-10. doi: 10.1017 / S1092852919001019.

Ioannidis K1, Redden SA2, Valle S2, Chamberlain SR1, Grant JE2.

inahaneloang

MORERO:

Basebelisi ba marang-rang ba nang le bothata ba le bothata ba ho senyeha maemong a fapaneng a kelello. Patlisiso e fana ka maikutlo a hore li-COMT haplotypes li na le litlamorao tse fapaneng ho khetholliseng. Re batlile ho fuputsa liphapang liphatseng tsa lefutso tsa basebelisi ba marang-rang ba nang le bothata le hore na li ka re hlakisa phapang e ka bang teng phapusing ea kelello.

LITLHAHISO:

Re ile ra hira 206 e seng kalafo e batlang barupeluoa ba nang le litšobotsi tse tsotehang le ho fumana litlhaloso tsa sechaba, litsebi tsa bophelo, litsebo le tsebo ea liphatsa tsa lefutso hammoho le haplotypes ea lefutso ea COMT rs4680 le rs4818. Re ile ra tseba barupeluoa ba 24 ba ileng ba hlahisa tšebeliso ea marang-rang e ferekanyang (PIU) 'me ba bapisa PIU le barupeluoa bao e seng PIU ba sebelisa mokhoa o le mong oa ho hlahloba phapang (ANOVA) le li-square tse lekaneng.

LIKOTSO:

PIU e ne e amahanngoa le ts'ebetso e mpe ho etsa liqeto, ho sebetsa ka potlako, le mesebetsi ea mohopolo oa libaka. Mefuta e fapaneng ea liphatsa tsa lefutso e ne e amahanngoa le ts'ebetsong ea likamano, empa litefiso tsa PIU ha lia ka tsa fapana ho latela haplotypes e itseng ea COMT.

QETELLO:

Phuputso ena e bontša hore PIU e khetholloa ke ho haelloa ke liqeto likarolong tsa ho etsa liqeto; e boetse e fane ka bopaki ba likarabo tse phahameng tsa maikutlo le ho sitoa ho fumana tlhokomelo holima tlhokomelo e tsitsitseng, e leng sebaka sa morao-rao se lokelang ho hlahloba mosebetsi o tsoelang pele. Liphello tse fumanoang liphatsa tsa lefutso tse amanang le ho tseba litlhahiso tsa PIU li fana ka maikutlo a hore liphatsa tsa liphatsa tsa lefutso tsa PIU li ka 'na tsa se ke tsa e-ba ka har'a liphatsa tsa lefutso tse amang tšebetso ea COMT le ts'ebetso ea mohopolo; kapa hore motsoako oa liphatsa tsa lefutso oa PIU o ama liphatsa tsa lefutso tsa liphatsa tsa lefutso ka bomong tse fanang ka phello e fokolang feela.

LINKOTSO: COMT; Ts'ebeliso ea marang-rang e nang le mathata; temohisiso; liphatsa tsa lefutso; lekhoba la marang-rang

PMID: 31159911

DOI: 10.1017 / S1092852919001019