Pherekano ea Naha ea ho phomola Catecholamine le Mekhoa ea ho Tšoenyeha Bochabeng ba Bashemane ba Korea ba nang le Inthanete ea Lithethefatsi (2016)

Cyberpsychol Behav Soc Netw. 2016 Feb 5.

Kim N1, Hughes TL2, Sebaka sa boikhathollo sa CG2, Quinn L2, ID ea Kong3.

inahaneloang

Morero oa phuputso ena e ne e le ho bapisa boemo ba phomolo ba mmuso catecholamine le maemo a ho tšoenyeha a banna ba lilemong tsa bocha ba Korea ba nang le papali ea papali ea inthanete (IGA) le ba se nang IGA. Boithuto bona ba papiso ea likarolo tse fapaneng bo entsoe le baithuti ba banna ba 230 ba sekolo se phahameng toropong ea Korea Boroa. Ho ile ha sebelisoa mekhoa e bonolo ea ho etsa sampole le lehloa, 'me lintlha tsa bokelloa ho sebelisoa (1) disampole tsa barupeluoa ba nkang karolo ea mali tse hlahlojoang bakeng sa dopamine (DA), epinephrine (Epi), le norepinephrine (NE) le (2) lipotso tse peli tsa lipotso ho lekola maemo a IGA le matšoenyeho. Ho sebelisa SPSS 15.0, data e ile ea hlahlojoa ka tlhahlobo e hlalosang, χ2-liteko, liteko tsa t, le liteko tsa pearson tsa khokahano. Plasma Epi (t = 1.962, p <0.050) le NE (t = 2.003, p = 0.046) li ne li le tlase haholo sehlopheng sa IGA ho feta sehlopheng seo e seng sa IGA; Maemo a DA ha a ka a fapana haholo lipakeng tsa lihlopha. Boemo ba ho tšoenyeha bo bolelang ba sehlopha sa IGA bo ne bo phahame haholo ha bo bapisoa le sehlopha seo e seng sa IGA (T = -6.193, le <0.001). Ha ho likamano tse bohlokoa tse fumanoeng lipakeng tsa catecholamine le maemo a khatello ea maikutlo. Liphetho tsena li bontšitse hore papali e fetelletseng ea inthanete ha nako e ntse e feta e bakile ho fokotseha ha maemo a Epi le NE, ka hona ho fetola melao ea boipheliso, le ho eketsa maemo a ho tšoenyeha ho baithuti ba banna ba sekolo se phahameng. Ho ipapisitsoe le litlamorao tsena tsa mmele le kelello, mehato e reretsoeng ho thibela le ho alafa IGA e lokela ho kenyelletsa ho tsitsisa maemo a Epi, NE le matšoenyeho ho bacha.

Selelekela

Bokhoba ba inthanete (IA) ke e 'ngoe ea litaba tse amang bophelo ba sechaba sechabeng lefatšeng ka bophara. Korea, hoo e ka bang liphesente tse 100 tsa bacha ba kena Inthaneteng letsatsi le leng le le leng. Sekhahla sena se phahameng sa ts'ebeliso ea marang-rang se tsamaisana le keketseho ea IA. Ho ea ka phuputso ea haufinyane e entsoeng ke mmuso oa Korea, sekhahla sa IA ke liperesente tsa 11.7 har'a baithuti ba sekolo se mahareng le se phahameng, ba phahameng ka ho fetesisa ho lilemo tsohle Korea. Ho lemalla papali ea Inthanete (IGA) ke karoloana ea IA, mme IGA e amohetse tlhokomelo ea sechaba le lipatlisiso ho feta likaroloana tse ling tse kang ho sebelisa lits'ebeletso tsa marang-rang, ho shebella litšoantšo tsa bootsoa le ho reka inthaneteng. IGA e 'nile ea hlahlojoa haholo hobane e na le litlamorao tse tebileng ho motho ka mong le sechabeng ho feta mesebetsi e meng ea marang-rang ea marang-rang. Korea, papali ke sepheo se seholo sa ts'ebeliso ea Marang-rang har'a basebelisi ba inthaneteng ba kotsing e kholo, mme palo e ntseng e eketseha ea bacha e nkuoa e le kotsing ea IGA.

Batho ba nang le IGA, ba hlalosoang e le ts'ebeliso e fetelletseng kapa e qobelloang ea lipapali tse sitisang bophelo ba letsatsi le letsatsi, ba tloaetse ho itšehla thajana le ho tloaelana le batho mme ba tsepamisa mohopolo haholo mesebetsing ea papali. Likarolo tsa IGA le IA li kenyelletsa ts'ebeliso e fetelletseng le e sa laoloang ea inthanete le mathata a bophelo ba letsatsi le letsatsi. Ntle le moo, litekanyetso tsa tlhahlobo ea IGA le IA lia tšoana hobane, ka kakaretso, li nkiloe ho Buka ea ho hlahloba le ea Statistical ea Mathata a kelello (DSM) litekanyetso tsa papali ea chelete. Ka mabaka ana, mantsoe IGA le IA a sebelisitsoe ka ho fapakaneng lithutong tse ngata tse fetileng. Leha ba bang ba pheha khang ea hore maemo a lokela ho hlophisoa hammoho, Litšobotsi tsa palo ea batho le likarolo tsa bongaka tsa batho ba nang le IGA le IA li tloaetse ho fapana. Mohlala, IGA e atile haholo hara banna ho feta basali mme e beha kotsi e tlase ea khatello ea maikutlo ho feta IA. Ho feta moo, taba ea hore Khatiso ea Bohlano ea DSM (DSM-V) e kenyelelitse boloetse ba papali ea inthanete e le boemo bo lumellang thuto e tsoelang pele e totobatsa bohlokoa ba papali ea marang-rang e fapaneng le ketsahalo e pharalletseng ea IA.

Le ha batho ba nang le IGA ba na le bothata bo boholo ba ho laola papali ea bona e fetelletseng ea inthanete mme IGA e lemohuoa e le bothata bo tebileng ba kelello, ha ho na tlhaloso e tloaelehileng kapa ho kenella bakeng sa IGA ka nako ena.,, Ho fihlela joale, liphuputso tse 'maloa li se li supile lintlha tse amanang le IGA. Boholo ba lipatlisiso bo shebane le likotsi tsa botho le tsa kelello,, ka khatello ea maikutlo ke e 'ngoe ea lisosa tsa bohlokoahali tsa kelello le kelello., Khafetsa, IGA e tsamaea le mathata a mang a kelello a joalo ka khatello ea maikutlo, ho tšoenyeha kapa khatello ea maikutlo.,, maemo a boetse a amahanngoa le khatello ea maikutlo. Liphuputsong tse ngata tsa morao-rao tsa methapo ea pelo, leha ho le joalo, liphetoho tse hlakileng tsa sebopeho le ts'ebetso li fumanoe sebakeng sa limbic le prefrontal cortex ea boko ho batho ba lemaletseng inthanete., Liphuputso tsena li bonts'a hore ts'ebeliso ea papali ea Inthanete e pheta-phetoang le e fetelletseng e ka fetola sebopeho sa boko le ts'ebetso ea methati e ikhethileng ea ts'ebeliso ea kelello, e lebisang ho likhaello tsa taolo ea kelello tse lebisang ho IGA., Leha ho le joalo, ha ho tsejoe hanyane ka litšobotsi tsa mmele o ipapisang le IGA.

Hoa hlokomeleha hore papali ea inthanete e amana le liphetoho ho cortisol ea salivary, tsoho ea mmele, le ho fetoha ha phapang ea sekhahla sa pelo, nakong ea papali ea papali. Liphetoho tsena tse mpe tsa 'mele li bonoe le maemong a basal (nongaming) har'a batho ba nang le IGA. Thutong e fetileng, re fumane maemo a maholo a "cortisol" a "basal-state" ho basebelisi ba papali ea inthanete ha ba bapisoa le basebelisi ba sa sebetseng. Liphuputso tse tsoang lithutong tsa rona le tse ling tsa 'mele li fana ka maikutlo a hore ts'ebeliso e fetelletseng ea lipapali tsa inthanete e amahanngoa le khatello ea maikutlo,, leha liphetho li sa lumellane.

Ho imeloa kelellong ho nkoa e le sesosa sa mefuta e mengata ea bokhoba ba tahi., Ho imeloa kelellong ho baka liphetoho tse ngata 'meleng mme e hlahisitsoe e le mochini o kanna oa ts'ehetsa nts'etsopele ea IGA. Leha ho na le likamano tse hlakileng lipakeng tsa khatello ea maikutlo le ho lemalla lithethefatsi, ke lithuto tse fokolang tse lekileng ho tseba likarabo tsa khatello ea mmele ho IGA. Leha li-catecholamine ke karolo ea pele ea karabelo ea mmele ho khatello ea maikutlo, maemo a plasma catecholamine ha a lekanngoe ho batho ba nang le IGA.

Catecholamines, ho kenyeletsoa le dopamine (DA), norepinephrine (NE), le epinephrine (Epi), li laola khatello ea maikutlo e bakoang ke khatello ea maikutlo. Ka tloaelo likarabo tsa khatello ea maikutlo li thusa batho ho ikamahanya le litšusumetso tse kantle le tse ka hare ka ho kenya tšebetsong litsamaiso tse peli tse kholo: sistimi e potlakileng ea kutloelo-bohloko ea adrenergic (SAS) le sekhahla se liehang sa hypothalamic-pituitary-adrenal axis., SAS e ntša li-catecholamine ho tsoa liphellong tsa methapo e nang le kutloelo-bohloko le litšoelesa tsa adrenal, mme lik'hemik'hale tsena li sebetsa e le karolo e sebetsang ho baka likarabo tsa "ntoa kapa ho fofa" maemong a tšohanyetso. Le ha li-catecholamine tsa pheriferale li sa kenelle ho mokoallo oa mali le boko, ho potoloha Epi le NE ho kanna ha buisana le li-neuron tsa dopaminergic le noradrenergic ka tsela e amanang le vagal., Ka hona, karabelo e sa lekanang ea SAS e ka baka nts'etsopele ea maloetse a fapaneng a hlobaetsang le a sa foleng, ho kenyeletsoa le lithethefatsi., Ka mabaka ana, li-catecholamine li reretsoe ho thibela le ho phekola bothata ba lipapali tsa inthanete.,,

Thutong ea hajoale, re hlahlobile lits'oants'o tsa 'mele tse bakoang ke khatello ea maikutlo ho li-catecholamine tsa plasma-ke hore, litekanyetso tsa DA, Epi le NE-ho lithuto tsa IGA le tseo eseng tsa IGA. Hobane matšoenyeho a amahanngoa haholo le catecholamines tsamaisong ea methapo e bohareng (CNS),, re boetse re hlahlobile maemo a ho tšoenyeha e le sesupo sa khatello ea maikutlo. Ka kakaretso, khatello ea maikutlo e baka likarabo tse nang le kutloelo-bohloko ka ho lokolloa ha catecholamine, ka hona, likarabo tsa khatello ea maikutlo tse telele li ka baka khatello ea maikutlo. Ka hona, re ile ra nahana hore bacha ba lilemong tsa bocha ba nang le IGA ba tla bontša phetoho maemong a plasma catecholamine le maemo a phahameng a ho tšoenyeha ho feta ba sa lemaletseng papali ea inthanete. Re ile ra tsoela pele ho nahana hore maemo a catecholamine a tla amahanngoa le maemo a ho itlhalosa a tlalehiloeng.

mekhoa

Barupeluoa le lits'ebetso

Lihlooho e ne e le bashemane ba lilemo li 15 ho isa ho 18 ba neng ba hiriloe likolong tse robong tsa thuto e phahameng ea litoropo Korea. Hobane bacha ba lilemong tsa bocha ba tloaetse ho lemalla papali ea inthanete, mme lihormone tsa basali tsa thobalano li ka ama taolo ea lihormone tse amanang le lithethefatsi joaloka DA, thuto e ne e lekanyelitsoe ho baithuti ba banna feela. Baithuti ba nang le boemo ba bongaka bo fumanoeng kapa ba noang meriana (mohlala, β-blockers kapa sedatives) tse ka amang maemo a plasma a catecholamine le bona ba ile ba qheleloa ka thoko. Re sebelisitse mekhoa e bonolo le mehlala ea lehloa bakeng sa ho hira. Re ne re etela sekolo se seng le se seng se phahameng 'me re fumana tumello ea ho hlalosetsa baithuti thuto. Joale re ile ra kena ka phapusing e ngoe le e ngoe ka nako ea khefu ho hlalosa sepheo le lits'ebetso tsa thuto le ho mema baithuti ba nang le thahasello ho nka karolo. Ho eketsa boholo ba mehlala, re kopile lihlooho tse ngolisitsoeng nakong ena ho mema metsoalle eo e neng e le basebelisi ba lipapali tsa Inthanete ho ea le bona setsing sa pokello ea lintlha, moo ba ileng ba hlahlojoa hore ba tšoanelehe.

Lintlha li ile tsa bokelloa setsing sa lipapali sa sechaba. Sehlooho se seng le se seng se phethile lipotso tsa lipotso tse peli ka phapusing ea motho, mme ho ile ha huloa mehlala ea mali. Lintlha li ile tsa bokelloa lipakeng tsa 8:00 le 10:00 am tlasa maemo a tšoanang. Lihlooho tsohle li ile tsa itima lijo lihora tse 12 pele ho sampole ea mali. Ba kopiloe ho tlohela ho tsuba, ho noa lino tse nang le k'hafeine, le lipapali tsa inthanete lihora tse 24 pele ho pokello ea lintlha mme ba khothalletsoa ho robala ka ho lekaneng bosiung ba pele ho pokello ea lintlha. Phuputso ena e amohetsoe ke Boto ea Setsi sa Tlhahlobo ea Setsi sa Yonsei University Wonju College of Medicine. Re fumane tumello e ngotsoeng e nang le tsebo ho tsoa nthong ka 'ngoe le ho mohlokomeli oa hae oa molao.

Mehato

Papatso ea papali ea inthanete

Ho lekola IGA, re sebelisitse Online Game Addiction Scale for Adolescents, e ntlafalitsoeng ke Korea Agency for Digital Opportunity and Promotion (KADO) e ipapisitse le litekanyo tsa IA tsa pejana, tlhaiso-leseling bakeng sa batho ba lemaletseng papali ea Inthanete le lipuisano tsa sehlopha sa litsebi. Sekala se thehile ho ts'epahala le ho nepahala mme se sebeliselitsoe ho lekola IGA har'a bacha ba Korea lipatlisisong tsa naha. Sekala se na le lintho tse 20 tse nang le likhetho tsa likarabo ho tloha 1 = "ho hang" ho 4 = "kamehla" (lintlha = 20-80, ka lintlha tse holimo tse bontšang IGA e kholo). Sekala se na le liphallelo tse tharo: (1) bophelo bo shebaneng le papali (mohlala, "Ke ikutloa ke le betere ha ke le lefatšeng la papali ho feta bophelong ba nnete"), (2) tahlehelo ea mamello le taolo ("Ha ke khone ho laola palo ea lihora tseo ke bapalang lipapali tsa inthanete "), le (3) ho tlohela le boiphihlelo bo matla (" Ke ikutloa ke tšoenyehile ebile ke tšohile ha ke sa khone ho bapala lipapali tsa inthanete "). Ho ea ka KADO, lintlha tse 49 kapa tse holimo sekaleng li bontša kotsi e kholo ea IGA, 'me lintlha tse 38 kapa kaholimo li bontša ts'ebeliso e fetelletseng le e ka bang kotsing ea IGA e ka bakang mathata a mang bophelong ba letsatsi le letsatsi. Alpha ea sekala sa Cronbach thutong ea hajoale e ne e le 0.93. Ho ipapisitsoe le lintlha tsa IGA, lithuto li ile tsa abeloa sehlopha seo e seng sa IGA kapa IGA.

Maemo a Plasma catecholamine

Li-catecholamine tse tharo tsa lero la mali — DA, Epi le NE — li ​​ile tsa lekoa ho sebelisoa lisele tsa mali. Taba ka 'ngoe e ne e laetsoe ho robala ka khutso metsotso e 20 pele ho sampole ea mali. Mali a maqhubu (5 mL) a ile a ntšuoa a sebelisa tube ea heparin anticoagulation. Methati ea Catecholamine e ne e lekantsoe ke chromatography ea metsi a phahameng haholo (Agilent 1200 series; Agilent Technology).

Matšoenyeho

Re ile ra lekanya matšoenyeho re sebelisa Revised Children's Manifest Anxiety Scale (RCMAS), Boemo ba matšoenyeho a bacha ba lilemo li 37 ho isa ho tse 6. RCMAS e kenyelletsa matšoao a 19 a ho tšoenyeha a tloaelehileng (e / che) a hlophisitsoeng ka likaroloana tse tharo tse lekolang ho tšoenyeha ha mmele, ho tšoenyeha / ho ba le kutlo e fetelletseng le ho ameha sechabeng (mohlala, "I ke tšaba lintho tse ngata, ”“ Ke tšohile, ”hape“ Ke lula ke tšoenyeha ka ntho e mpe e etsahalang ka nna ”). Kakaretso ea litekanyetso e tloha ho 37 ho ea ho 0, 'me lintlha tse kaholimo ho 37 li nkuoa e le tsa bohlokoa tleliniking. Alpha ea sekala sa Cronbach thutong ea hajoale e ne e le 15.

Tlhahlobo ea lintlha

Lintlha li ile tsa hlahlojoa ho sebelisoa SPSS 15.0. Ho ne ho sebelisoa mekhoa, likhelo tse tloaelehileng, maqhubu le liperesente ho akaretsa lintlha tse amanang le papali ea batho le inthanete. Lintlha tsa DA, Epi, le NE li ne li sa ajuoe ka tloaelo ebe li fetoloa ke logarithm ho fihlela kabo e tloaelehileng. Ikemetseng t-liteko li ne li sebelisetsoa ho bapisa lero la mali la DA, Epi, le NE le matšoenyeho lihlopheng tsena tse peli. Likamano lipakeng tsa plasma catecholamine le maemo a khatello ea maikutlo li ile tsa hlahlojoa ho sebelisoa coefficient ea Pearson. A pBohlokoa ba <0.05 bo ne bo nkuoa e le ba bohlokoa.

Results

Lethathamo 1 e hlahisa litšobotsi tse amanang le papali ea palo ea batho le ea inthanete. Lilemo tsa thuto e ne e le lilemo tse 16.63 ± 1.02 'me boima ba' mele e ne e le 21.91 ± 3.69 kg / m2. Hoo e ka bang liperesente tsa 25 li tlalehile hore ba tsuba lisakerete le / kapa ba noa lino tse tahang. Hoo e ka bang likarolo tse peli ho tse tharo (liphesente tse 68.3) li ne li tsoa malapeng a amohelang chelete ka bobeli. Nako ea ho robala ea letsatsi le letsatsi e fapane haholo le ho tseo e seng IGA le IGA lihlopha (χ2 = 5.616, p = 0.018). Maqhubu a lipapali tsa Inthanete beke le beke (χ2 = 45.994, p <0.001) le nako ea papali ea marang-rang ea letsatsi le letsatsi (t = -7.332, p <0.001) li ne li phahame haholo sehlopheng sa IGA. Karolelano ea nako ea papali ea inthanete e ne e le lilemo tse 6.82 ± 2.38 sehlopheng seo e seng sa IGA le lilemo tse 7.64 ± 2.42 sehlopheng sa IGA (t = -2.409, p = 0.017). Karolelano ea lintlha tsa IGA li ne li batla li phahame habeli sehlopheng sa IGA (46.05 ± 8.96) joalo ka sehlopheng seo e seng sa IGA (26.43 ± 4.94; t = -20.708, p <0.001).

Tafole 1. 

Papiso ea Litšobotsi tse Amanang le Palo ea Batho le Marang-rang tsa Non-IGA le IGA Group (N = 230)

Lihlopheng tseo e seng tsa IGA le IGA, litekanyo tse boleloang tsa DA li ne li le 56.95 ± 75.04 le 68.66 ± 82.75 pg / mL; Epi e ne e le 64.06 ± 94.50 le 48.35 ± 44.96 pg / mL, mme NE e ne e le 412.95 ± 274.68 le 330.86 ± 178.67 pg / mL, ka ho latellana. Lethathamo 2 e akaretsa ka mokhoa o fetotsoeng oa catecholamine ea plasma le matšoenyeho lihlopheng tsena tse peli. Maemo a sehlopha sa IGA sa plasma Epi le NE a ne a le tlase haholo ha a bapisoa le sehlopha seo e seng sa IGA (t = 1.962, p <0.050 le t = 2.003, p = 0.046, ka ho latellana). Maemo a DA ea plasma a ne a phahame bakeng sa sehlopha sa IGA, empa eseng joalo haholo. Maemo a khatello ea kelello a ne a phahame haholo sehlopheng sa IGA (t = -6.193, p <0.001). Ha ho likamano tse bohlokoa tse fumanoeng lipakeng tsa catecholamine le maemo a khatello ea maikutlo. Leha ho le joalo, lintlha tsa IGA li ne li amana haholo le maemo a ho tšoenyeha (r = 0.452, p <0.001), 'me nako ea papali ea inthanete ea letsatsi le letsatsi e ne e amana hampe hanyane le maemo a plasma NE (r = -0.142, p = 0.032). Lethathamo 3 e bonts'a sephetho sa tlhahlobo ea likamano.

Tafole 2. 

Papiso ea Plasma Catecholamine le Maemo a ho Tšoenyeha a Lihlopha tseo e seng tsa IGA le IGA (N = 230)
Tafole 3. 

Khokahano lipakeng tsa mefuta-futa (N = 230)

Puisano

Re ile ra batlisisa hore na bacha ba nang le IGA le ba se nang IGA ba fapane joang le maemo a plasma a catecholamine le maemo a bona a ho itlhalosa. Re fumane phapang e kholo lipakeng tsa li-plasma tsa Epi le NE lipakeng tsa lihlopha tsena tse peli. Lefapheng la kelello, lipalo tsa ho tšoenyeha li ne li phahame haholo sehlopheng sa IGA ho feta sehlopheng seo e seng sa IGA. Sehlopha sa IGA se tlalehile karolelano ea lilemo tse 7.64 le lihora tse 3.79 / letsatsi la lipapali tsa inthanete (ha li bapisoa le lilemo tse 6.82 le lihora tse 1.89 / letsatsi sehlopheng seo e seng sa IGA). Papali ena ea inthanete e telele haholo e kanna ea amana le liphetoho lipakeng tsa Epi le NE le maemo a phahameng a ho tšoenyeha sehlopheng sa IGA. Methati ena e kanna ea amahanngoa le khatello ea maikutlo e amanang le papali hobane (1) Lipapali tsa inthanete li hlohlellelitse ts'ebetso ea kutloelo-bohloko lithutong tse fetileng,, le (2) mesebetsi ea papali e 'nile ea sebelisoa khafetsa e le khatello ea maikutlo lithutong tse lekanyang ts'ebetso ea pelo le methapo., Liphetho tsa rona li bonts'a hore ts'ebetso ea papali ea inthanete ka boeona e ka baka khatello ea 'mele eo, haeba e tsoela pele ha nako e ntse e feta, e ka fella ka IGA. Liphetho tsa rona tsa plasma catecholamine li tšehetsa boteng ba khatello ea 'mele e bakoang ke papali ea inthanete.

Ho khahlisang ke hore maemo a plasma Epi le NE a ne a le tlase ho IGA ho feta lithuto tseo e seng tsa IGA. Liphuputso tsena li fapana le maemo a phahameng a catecholamine a amanang le mathata a mang a kelello a kang lefu la khatello ea maikutlo. Ntle le moo, tlhaiso-leseling ea naha ea rona ea ho phomola e bonts'itse mekhoa e fapaneng le e bonoang lithutong tse ngata tse fetileng moo molumo o eketsehileng oa kutloelo-bohloko o etsahetseng nakong ea / kapa hang kamora teko ea papali.,, Liphuputso tsa rona li tsamaellana le tsa thuto e nyane ea taolo ea linyeoe moo bacha ba nang le IA ba bonts'itseng maemo a tlase a serum NE ho feta a se nang IA. Ebile, ea rona ke thuto ea pele e bonts'ang bohlokoa ba catecholamine ea pherifera ho IGA. Le ha Epi -e leng karolo e kholo ea pherifateal catecholamine-e laola ntoa kapa karabelo ea sefofane, liphuputso tse fokolang li lekantse likarabo tsa Epi. Likhetho ke lithuto tsa morao-rao moo ho fanoeng ka tlhokomelo e eketsehileng ho likarolo tse khethollang Epi mafung a nakoana le a nako e telele a bakoang ke khatello ea maikutlo joalo ka mafu a pelo, methapo ea mafu, mofetše le mafu a kelello.

Ho ipapisitse le seo re se fumaneng, ha re khone ho hlalosa mekhoa ea motheo ea phokotso ea mali ea catecholamine sehlopheng sa IGA. Leha ho le joalo, lits'ebetso li kanna tsa amahanngoa le "sensitization" kapa "downregulation" e bonoang ho CNS ea batho ba lemaletseng lipapali tsa video., Bafuputsi ba fumane hore tšusumetso e telele ea kutloelo-bohloko e hatella sistimi ea moputso oa boko ba DA. Khatello ena e fumanoe ka mokhoa oa ho fumaneha le ho lula ha DA (D2) e tlase, le ho theola palo ea bapalami ba DA lipapaling tsa video tse feteletseng. Tlhaloso e tlase e hlalosoa e le ho fokotseha ha likarolo tsa lisele, ho kenyelletsa li-receptor le ba tsamaisang thepa, ho arabela tšusumetso ea kantle; Ho fokotseha hona ho fokotsa kutloisiso ea sele ho li-stimuli. Bopaki bo bong bo teng bakeng sa ts'oaetso ea dopaminergic ka har'a li-receptor tsa cellular le bapalami ba lemaletseng inthanete,, ketsahalo e thehiloeng hantle joala le ba sebelisang hampe lithethefatsi tse ling.,

Tlhaloso e tlase e ka hlalosa maemo a fokotsehileng a pate ea plasma ea catecholamine sehlopheng sa rona sa IGA. Ho imeloa kelellong nako e telele ho bakoang ke lipapali tse phehellang tsa inthanete ho ka qetella ho bakile phokotso ea maemo a mali a Epi le NE ka lebaka la taolo e tlase ea taolo e bonts'ang likarabo tse feto-fetohang. Boemong ba CNS, ho theoha hoa nako e telele ha li-receptor ho ka kenya letsoho ho senyeheng ha ts'ebeliso ea kelello, eo ho nahanoang hore ke sesosa sa nts'etsopele ea IGA., Ka mantsoe a mang, ho fokotseha ho bakoang ke khatello ea kelello ts'ebetsong ea ts'ebetso ho ka potlakisa phetoho ho tloha boits'oaro ba boithatelo ho ea boits'oarong ba boithatelo. Leha ho le joalo, ha rea ​​ka ra lekanya taolo e tlase ea receptor e amanang le catecholamines thutong ena. Patlisiso ea nako e tlang e lokela ho batlisisa kamano e ka bang teng lipakeng tsa maemo a catecholamine ea pherifera le bongata kapa ho lula ha li-catecholamine receptors. Mabapi le DA, catecholamine ena e bapala karolo ea bohlokoa ho mathata a mangata a kelello maemong a CNS. Leha ho le joalo, mesebetsi ea DA ho plasma, eo mehloli ea eona e meholo e kenyelletsang ho ja le methapo ea kutloelo-bohloko, ha e utloisisoe hantle. Ho ipapisitsoe le tlhaiso-leseling ea rona, DA ea pherekano, ho fapana le DA bokong, e kanna ea se ke ea kenella ho IGA.

Ntle le lits'ebetso tsa mmele, likarabelo tsa khatello ea maikutlo li kenyelletsa mekhoa ea kelello. Ho tšoenyeha ke karolo e kholo ea khatello ea maikutlo mme ho amahanngoa le kotsi e kholo ea ho lemala. Ho latela lipatlisiso tsa IA tsa nakong e fetileng, re fumane maemo a phahameng a ho tšoenyeha sehlopheng sa IGA., Zhang et al. a pheha khang ea hore ho eketseha ha matšoenyeho ho ka amahanngoa le ts'ebetso e fetotsoeng ea ts'ebetso ea NE ho batho ba lemaletseng inthanete; leha ho le joalo, ha rea ​​fumana kamano lipakeng tsa matšoenyeho le maemo a catecholamine thutong ea rona. Tlhaloso e ka bang teng ea ho se lumellane hona ke ts'ebeliso ea mehato e fapaneng ea ho lekola matšoenyeho (ke hore, athe Zhang et al. O sebelisitse Tekanyo ea Matšoenyeho a Boithati, re sebelisitse RCMAS). Tlhaloso ea bobeli e ka bang teng ke hore boemong ba CNS, ts'ebetso e ts'oarellang ea sistimi ea NE e bakoang ke ho pepeseha khatello ea maikutlo nako e telele e hokahantsoe le keketseho ea matšoenyeho a mefuta ea liphoofolo., Leha ho le joalo, maemong a pherekano, lits'ebetso tsa 'mele le tsa kelello e kanna ea ba li ne li nkile karolo ho IGA lithutong tsa rona tsa batho, leha ho na le taba ea hore Epi, NE, le maemo a ho tšoenyeha a ne a fapane lipakeng tsa IGA le lihlopha tseo e seng tsa IGA. Ka lehlakoreng le leng, re ne re ke ke ra qhelela ka thoko monyetla oa hore lintlha tse ling li buelle kamano lipakeng tsa catecholamine ea plasma le matšoenyeho. Liphuputso tse ling li hlokahala ho hlakisa hore na mekhoa ea 'mele le ea kelello e sebetsa joang ka boikemelo ho IGA le hore na ke lintho life tse sebetsanang le kamano lipakeng tsa plasma catecholamine le maemo a khatello. Haholo-holo, re ne re sa khone ho tseba hore na keketseho ea matšoenyeho e ne e le sesosa sa ho itšireletsa kapa sesupo sa papali e fetelletseng ea inthanete ka nako. Boemong bofe kapa bofe, ho tšoenyeha e lokela ho ba sepheo sa mantlha sa maano a thibelo le boits'oaro ba bacha ba kenang lipapaling tse ngata tsa inthanete.

Kaha lingoliloeng tse fetileng li supile phokotso ea khatello ea maikutlo e le lebaka le leholo la ts'ebeliso e fetelletseng ea inthanete,, liphetho tsa rona li fana ka tlhaiso-leseling e ncha ea bohlokoa. Ho ipapisitsoe le liphetho tsa rona tsa mmele le kelello, re fana ka mohopolo oa boiteko mabapi le kamano lipakeng tsa khatello ea maikutlo le IGA, re fana ka maikutlo a hore khatello ea kelello e sa lebelloang e ka kopana le khatello ea 'mele e bakoang ke mesebetsi ea nako e telele ea papali ho kenya letsoho ntlafatsong ea IGA. Le ha lipatlisiso tse ling li hlokahala ho khetholla lits'oants'o tse ling tsa 'mele le ho utloisisa hamolemo lits'ebetso tse tsamaisang IGA, liphetho tsa rona li bonts'a bohlokoa ba lintlha tsa mmele le tsa kelello ho IGA. Liphuputso tsena li ka kenya letsoho ho khetholla mekhoa ea pathophysiological ea IGA.

Liphetho tsa rona li na le moelelo o motle bakeng sa tlhahlobo ea IGA le kalafo, ho kenyeletsoa le tlhoko ea tlhahlobo ea IGA ea mmele le kelello bocheng. Hajoale, litlhahlobo tse joalo li shebane haholo le ho lekola liphetoho tsa boits'oaro le lits'oants'o tsa boits'oaro. Ntle le moo, liphetho li na le moelelo bakeng sa nts'etsopele ea maano a kalafo bakeng sa bacha ba nang le IGA. Mohlala, mehato e reretsoeng ho thibela le ho phekola IGA ho bacha e kanna ea hloka ho shebana le ho tsitsisa maemo a Epi, NE le matšoenyeho.

Leha ho na le matla a hlokomelehang a boithuto, ho lokela ho nahanoe meeli e 'meli. Taba ea mantlha, hobane lintlha tsa rona li arohane, mekhatlo ea causal har'a IGA, plasma catecholamine le matšoenyeho li ne li ke ke tsa tsebahatsoa. Ho hlokahala lithuto tsa nako e telele ho netefatsa sephetho sa boithuto. Taba ea bobeli, IGA e ile ea metoa ka seletsa sa ho itlaleha. Lihlooho tse amehileng ka ho khetholloa e le makhoba e ka 'na eaba li ne li sa tlalehe nako eo ba e qetileng ba bapala Inthaneteng, e leng se neng se fella ka ho nyenyefatsa IGA.

lumela hore baa fokola

Bangoli ba leboha Mofumahali Eunju Kim, RN, ea thusitseng ka pokello ea lintlha, le Monghali Jon Mann ka thuso ea hae ea bongoli nakong ea boitokisetso ba sengoloa. Phuputso ena e ne e tšehelitsoe ke Lenaneo la Motheo la Patlisiso ea Saense ka Setsi sa Naha sa Lipatlisiso sa Korea (NRF) se tšehelitsoeng ke Lefapha la Thuto, Saense le Theknoloji (NRF-2012R1A1A4A01012884).

Tlhaloso ea Mongoli oa Tlhaloso

Ha ho na lithahasello tsa tlholisano tsa lichelete tse teng.

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